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Candida albicans Genome Fully AnnotatedThe National Research Council of Canada heads an international team, bringing new hope to people with immune system deficiencies
Montréal, July 25< 2005 — The National Research Council Biotechnology Research Institute (NRC-BRI) today announced the publication of an article that reveals the complete genomic annotation of Candida albicans, a fungal pathogen that is one of the main causes of infection in people with weakened immune systems, and currently very difficult to treat. This article will appear in the first issue of the American journal PLoS Genetics, being published July 25, 2005. An advance copy of this article is available at http://www.plosgenetics.org/ . This most extensive annotation of the Candida albicans genome was presented at the General Meeting of the American Society for Microbiology in Atlanta in June 2005. Since 2002, NRC-BRI has been the coordinating centre for the international group of 43 scientists from 7 countries working on this project. “The complete sequencing of Candida albicans provided the template,” said André Nantel, Ph.D., head of NRC-BRI’s microarray lab and one of the project’s lead researchers. “As a result of our subsequent efforts, the international scientific community now has a better interpretation of the genomic and proteomic data for C. albicans. Work on Candida and on its pathogenesis will now progress more quickly towards more effective treatments,” he added. A dangerous fungal pathogen for immunodeficient patients Candida infections are difficult to treat. Current treatments are only somewhat effective, given the microorganism’s resistance to antibiotics and their serious side effects. The complete and precise annotation of this yeast’s genome will help researchers better understand the pathogen’s weaknesses and improve upon current therapeutic agents. Based on the Candida albicans annotations, the NRC-BRI team has successfully produced the first noncommercial microarray that can be used by researchers around the world to further study the genomics and proteomics of Candida. The Candida albicans microarray consists of an orderly arrangement of about 6000 DNA samples on a glass slide. Other microarrays vary in size and are used to examine entire genomes. They can also simultaneously evaluate the expression and interactions of an organism’s genes, a key step towards developing more effective medical treatments. About NRC-BRI About the National Research Council of Canada Pierre Naud For more information, please contact NRC-BRI by phone at 514-496-6100 or by email to bri-communication@cnrc-nrc.gc.ca. |
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