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Service Standard for Referencing and Summarizing Toxicological Information in Advice Documents and Toxicity Profile Summaries /
Service Standard for Referencing and Summarizing Toxicological Information in Advice Documents and Toxicity Profile Summaries
The objective of this Service Standard is to improve the consistency of advice and improve the efficiency of
the Material Safety Data Sheet (MSDS) Compliance Division in the production of Advice Documents (AD) and
Toxicity Profile Summaries (TPS).
Part I of this Service Standard describes the information which must be
included when summarizing a toxicological study for inclusion in an AD or TPS. The information indicated as
“mandatory” must be present in a study or the study is considered as not meeting the criteria of the
Service Standard and the study is not evaluated further. The information which is indicated as “if available”
is to be included in the summary in order to give the reader a better understanding of the nature and scope of the
investigation.
Part II of this Service Standard outlines the referencing requirements
for various toxicological endpoints under circumstances which will or will not result in a change in classification
for the controlled product. Primary sources referred to in this section should be available in English or French
and if foreign sources are used they must be fully translated.
Appendix I provides a list of reliable secondary references to be used
in AD and TPS. The criteria applied in compiling the list of reliable secondary references included those that
reference the primary source of information and those which based on experience and professional judgement,
generally provide reliable information. The list should not be considered “all inclusive” and may
change from time to time, as more secondary references become available.
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