Advanced Mass Spectrometry

	Senior Research Officer Dr. Dietrich Volmer Post-doctoral Fellow Dr. Dave Craft Doctoral Students Lori Jessome Lekha Sleno

Our Advanced Mass Spectrometry program has ten state-of-the-art mass spectrometers available for our life sciences and advanced technology research. Geometries available include triple-quadrupole, quadrupole/time-of-flight, ion-trap, hybrid quadrupole-linear ion-trap, and a soon-to-be installed FTICR.

We work in the development of new instrumental technology and advanced bioanalytical applications of mass spectrometry. We are particularly interested in biological molecules and pharmaceutical compounds, their metabolites, structure elucidation techniques, and fundamental aspects of mass spectrometry such as the underlying physical phenomena that affect ionization efficiencies and dissociation behaviour in the gas-phase.

Another area of our research is in the mass spectrometric characterization of marine biotoxins using collision-induced dissociation.

Our Projects

Advanced resonance excitation methods:

Implementation of advanced resonance excitation methods in ion-trap mass spectrometry.

Analysing small molecules with MALDI:

Investigation of novel approaches for analyzing small molecules, such as pharmaceutical drugs, by MALDI and quantitative MALDI.

Applications of automated capillary liquid chromatography:

Applications of automated capillary liquid chromatography/MALDI-TOF-MS in drug analysis, aquaculture and proteomics.

Development of novel MALDI matrices:

Development of novel MALDI matrices, improved MALDI targets (next generation anchor chips) and on-target derivatization reagents.

High-throughput metabolite identification in marine organisms:

Exploration of high-throughput metabolite identification in marine organisms using innovative mass spectrometry techniques.

Host-guest chemistry of macrocyclic antibiotics and biotoxins:

Study of the host-guest chemistry of macrocyclic antibiotics and biotoxins using collision-induced dissociation and thermo-neutral selected ion flow tube MS/MS.

Our Facilities

Advanced Mass Spectrometry Research and Proteomics Technology Development Center

Our Publications

	Volmer, D.A. and Sleno, L. 2005. Modern drug discovery and the progression toward a universal mass spectrometer. Analytical and Bioanalytical Chemistry, 381:90-92. [view]
	Sleno, L., Volmer, D.A. and Marshall, A.G. 2005. Assigning product ions from complex MS/MS spectra: the importance of mass uncertainty and resolving power. Journal of the American Society for Mass Spectrometry, 16:183-198. [view]
	Volmer, D.A. and Sleno, L. 2005. Mass analyzers: an overview of several designs and their applications, part II. Spectroscopy, 20(12):90-95. [view]
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