The aim of this PA is to support research characterizing, understanding and treating etiological and pathophysiological mechanisms common to both Fragile X syndrome (FXS) and autism (including autism spectrum disorders such as Rett syndrome). Applications submitted in response to this PA should focus on a topic related to understanding neural pathways, circuits, systems and molecules that play a role in the etiology or pathophysiology of FXS and may be implicated in autism (including autism spectrum disorders such as Rett syndrome). Studies emphasizing the identification of drug targets for new therapeutic drugs to treat FXS and autism are particularly encouraged. Research projects supported under this PA that include human subjects should include children affected with both FXS and autism and animal studies may include several model systems, e.g., mouse, fly and zebrafish. Basic neuroscience research in model systems should focus on both FXS and autism.
This program will be active until July 2, 2008. Applications may be submitted on the standard NIH receipt dates for new (February 1, June 1, October 1) or revised (March 1, July 1, November 1) applications. Full program and application details can be found in the NIH Guide to Grants and Contracts. For further information, please contact Astrid Eberhart at aeberhart@cihr-irsc.gc.ca
