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Aegera Thepareutics Inc.


Aegera Therapeutics Inc. 

Aegera Therapeutics is building an integrated world-class biotechnology company focused on signal transduction and apoptosis. Formed by the merger of Apoptogen and Exogen Neurosciences in May 2000, Aegera's primary therapeutic focus is in apoptosis control: killing cancer cells by inducing apoptosis, rescuing neurons from cell death, and implanting stem cells to restore function.

Neurology and cancer are two of the fastest growing unsatisfied segments in the pharmaceutical industry with large disease profit pools. Central nervous system (CNS) diseases is the Number 2 Therapeutic Area. Aegera's neurotrophin surrogate program 

links two distinct strategies: an enzyme target-based Trk A/B/C signalling strategy, and a cellular-based p75 NTR strategy. Aegera founders biochemically mapped these signalling pathways leading to the identification of novel molecular targets for drug design and discovery.

Target markets
Aegera Oncology Inc. was created with a mandate to bring to market novel therapies for cancer. The approach involves inducing apoptosis in cancer cells by blocking the action of specific anti-apoptotic proteins known as the Inhibitor of Apoptosis Proteins (or IAPs). High levels of these proteins permit many cancer cells to evade normal death signals or resist standard therapies. Aegera discovered five of these genes and currently holds 11 issued US patents, giving the company an exclusive route to drug discovery, gene-based therapies and diagnostics in the field.


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