| CIHR Institutes |
| IG Home |
| About IG |
| IG Funding |
| IG Publications & Resources |
| Annual Reports |
| Workshop Reports |
| Commissioned Reports |
| Archived News |
| IG Calendar of Events |
| Contact IG |
Institute of Genetics
Canadian Institutes of Health Research
123 Edward Street, Suite 1211
Toronto, ON M5G 1E2
www.cihr-irsc.gc.ca
© Her Majesty the Queen in Right of Canada (2005)
Cat. No.: MRI-21/2004
ISBN 0-662-68665-9
Message from the Scientific Director
Profile of the Institute
Outstanding Research
Outstanding Reseachers in Innovative Environments
Translating Health Research into Action
Effective Partnerships and Public Engagement
Organizational Excellence
Financial Statements
Appendices
As Scientific Director of the Institute of Genetics, my greatest satisfaction continues to be in working with the incredible community of researchers that is aligned with the Institute, with the communities of other CIHR Institutes, and with the other colleagues and organizations that make up the complex but rich mosaic of Canadian health research.
I am particularly grateful to the more than 100 members of the 12 Priority and Planning (P&P) Committees and the Voluntary Health Organizations (VHO) Working Group that advise the Institute Advisory Board about their domains of research.The P&P Committee structure that the IG has put in place has distributed the leadership of the Institute across the country and among a great diversity of research communities, leading to a "bottom-up" approach to setting our research priorities for strategic funding. The Chairs and members of the P&P Committees are now being recognized as important leaders of their Canadian research communities by their peers, a recognition that is very rewarding, both personally and professionally.This structure has allowed the Institute Advisory Board to advise and decide rather than do all the work.
The support for research from the IG in 2003-2004 includes, a Regular Funding Program that addresses ongoing needs of the research community. We are particularly proud of the Requests for Applications (RFAs) that comprise this program, which fill unique gaps in the Canadian funding landscape, and which have been well received by the research community.
The Program includes:
The Institute also posted five other RFAs that addressed specific needs identified by the research community. Particularly notable was the launching of the "Addressing Health Care and Health Policy Challenges of New Genetic Opportunities" RFA (pg. 7). This RFA posting was the culmination of three years of planning and meetings that brought together, for the first time, clinical genetics researchers and investigators from the health services community, to address the research needs of the exploding field of Health Services for Genetic Diseases, one of the six Research Priority Themes of the IG.This important RFA is a first step in creating a Canadian research community in this area, and was developed in consultation with researchers, provincial Ministries of Health and representatives of Federal Territories, as well as Health Canada.
The IG also co-led, with the Institute of Neurosciences, Mental Health and Addiction (INMHA), the Regenerative Medicine and Nanomedicine: Innovative Approaches to Health Research initiative (pg. 9). This initiative is particularly timely for Canada, given our emerging strengths in nanomedicine and our expanding excellence in stem cell research. In its continuing support of individual investigators, the IG supported three very successful national research meetings and two consultations that have had significant impact on their respective areas of research:
Finally, we are proud to have co-sponsored two important outreach programs, the "Be a Gene Researcher for a Week-the Ramon Hnatyshyn in Science Initiative" Program (pg. 13), with the Canadian Genetics Diseases Network and Canadian Gene Cure Foundation, and the "The Geee! In Genome" Exhibit that is being presented across Canada by the Canadian Museum of Nature.
I remain grateful for the enthusiastic support and wisdom of the Institute Advisory Board. In particular, I owe a great deal to the excellent counsel of Dr. Joel Weiner (Chair) of the University of Alberta, and Dr. François Rousseau (Vice-Chair) of the Université Laval.
Finally, I continue to be blessed with outstanding staff who manage the various programs of the Institute and who interact on a daily basis with the research community, CIHR in Ottawa, the other Institutes and funding organizations in the country.
Whatever success we have experienced is founded very substantially on their remarkable and effective organizational, leadership and diplomatic skills and their good judgment.These staff members are the Assistant Directors Milka Popov and Stephanie Robertson, my Executive Assistant and Project Manager, Jennifer Jennings, IG Administrative Assistant, Esther Berzunza and Project Officer, Amanda Devost. In addition, I am most grateful for the contributions of Nicola McDermott, who replaced Dr. Popov as Assistant Director in Toronto for most of the past year.The energy and enthusiasm of these staff members, and their tolerance of the foibles of the SD, are apparently endless.They make my job a pleasure.
Sincerely,
Roderick R McInnes, MD, PhD, FRS(C)
Scientific Director
CIHR-Institute of Genetics
Our Institute Advisory Board (IAB) consists of 16 individuals with exceptional qualifications and demonstrated leadership, from Canada and abroad, under the guidance of the Chair, Dr. Joel Weiner, and the Vice-Chair, Dr. François Rousseau (Appendix 1).The IAB provides essential expertise and advice regarding determination of the IG's strategic goals, implementation of initiatives, and communication with stakeholders and the broader community.
Our strategic goals will guide the IG's activities to:
The IG has carried out a range of activities to define its strategic directions.The most important task throughout has been to consult researchers, academics, clinicians, policy makers, voluntary health organizations, government, companies and other stakeholders with an interest in the mandate of the IG.The IG has been well received as a "bottom-up organization" by responding to the needs of individual investigators and ensuring that its strategic goals and research priorities are defined by the research community and other stakeholders.
Our mandate is to support research on the human and other genomes and on all aspects of genetics, basic biochemistry and basic cell biology related to health and disease, including the translation of knowledge into health policy and practice and the societal implications of genetic discoveries.
Established in December 2000, the Institute of Genetics (IG) is one of 13 virtual Institutes of the Canadian Institutes of Health Research (CIHR). The IG is based at The Hospital for Sick Children in Toronto, the home institution of the Scientific Director, Dr. Roderick R. McInnes.
A pivotal consultation forum was the Strategic Planning Retreat held in September 2002 (Aylmer, Quebec) where approximately 60 leading researchers, academics,
government and scientific policy makers in the genetics, basic biochemistry and basic cell biology research communities were invited to consider the proposed strategic directions and priority research themes presented in the draft strategic plan.These consultative activities led to the refinement of the IG's research priority themes and strategic goals.The IG continues to consult with researchers and stakeholders, adjusting its strategic directions in response to changing research needs.
Our priority and planning (P&P) committees are led, or co-led, by a distinguished Canadian researcher(s) with expertise and a strong commitment to advancing research in their specific area. It is the responsibility of each P&P Committee to:
Additional P&P Committees and a Voluntary Health Organization (VHO) Working Group enable development in other crucial areas, such as international collaborations in human genetics, new principal investigators and public engagement and knowledge exchange.
Our funding mechanisms include Regular Programs and Strategic Request for Applications (RFAs).
Our Regular Programs (continuous launch cycle) are a constant feature in the IG research funding landscape. Subject to an annual review by the Institute Advisory Board, these programs are designed to facilitate training and/or research within the IG's mandate:
Our Strategic Request for Applications (RFAs) align with our research priority themes. Examples of strategic RFAs launched during the reporting period include:
.jpg)
Figure 1 - Priority and Planning Committees and Working Group of the IG
The leadership of the Institute of Genetics is widely distributed across Canada.The location of the chairs of each P&P Committee or Working Group is indicated. The blue circles indicate P&P Committees that support the IG Research Priority Themes.The white circles indicate P&P Committees that support the IG Enabling Strategies.
Fostering Research
During this reporting period, the IG launched and/or funded six RFAs that aligned with three of the six IG research priority themes (Appendix 3).
Population Genetics, Genetic Epidemiology, and Complex Diseases
Novel Population Genetics and Genetic Epidemiological Methods for Studies of Complex Genetic Diseases Grants. The IG launched this RFA - in partnership with the Institute of Population and Public Health (IPPH) - to foster research and build capacity in the rapidly developing areas of population genetics and genetic epidemiology of complex diseases. This program will enable individuals or teams to develop the new theories, strategies and methodologies required to facilitate more conclusive, high-quality etiological studies of complex diseases, including genetic and environmental determinants over the life course. Of the 12 applications received to the December 2002 competition deadline, four were approved for funding.
Population Genetics and Genetic Epidemiology of Complex Diseases Operating Grants. Complex diseases are multifactorial in nature and result from the combined effects of variation at multiple genetic loci and environmental influences manifested over the life course.The elucidation of interactions between an individual's genetic endowment and the complex sequence of environmental exposures - physical, chemical, biological, developmental and social - that occur over the life-course are expected to provide the greatest insight into our under-standing of the etiology of human disease. In December 2003, the IG and IPPH issued a Research Priority Announcement (RPA) to provide support for investigators in this developing area of research, through jointly funded operating grants.The RPA process enables Institutes to fund highly rated applications responsive to their priorities submitted to the CIHR open competitions. Results of this competition will be available in the summer of 2004.
Our Values:
Health Services for Genetic Diseases
Staying Ahead of the Wave: Genetics, HealthServices and Health Policy Development Grants. In partnership with the Institute of Health Services and Policy Research (IHSPR), this program provides development funds in support of projects that are likely to lead to the development of proposals or programs of inquiry to "ensure that the inevitable growth in genetic health services is in accordance with scientific evidence and in a way that enables us reap its full benefit" (Health Services and Research Commission-HSURC, 2001). Of the 10 applications submitted to the January 2003 competition deadline, three were approved for funding.
Addressing Health Care and Health Policy Challenges of New Genetic Opportunities Operating Grants. The purpose of this program is to provide operating grant funds in support of research projects, the results of which will better equip health care providers, administrators and policy makers to improve the health of populations and strengthen the health care system in Canada in the face of the rapid growth in new technologies and understandings associated with the "genetics era". In partnership with the IHSPR, IPPH, Canadian Coordinating Office for Health Technology Assessment (CCOHTA) and the Heart and Stroke Foundation of Canada (HSFC), $1.65 million per annum for a term of three years has been secured for this initiative. Results of this competition will be available in the fall of 2004.
Genetics and Ethical, Legal and Social Issues
Facing our Future: Human Genetics, Ethics, Law and Society Development Grants. This RFA was launched in partnership with the Institute of Aboriginal Peoples Health (IAPH), Institute of Aging (IA), Institute of Human Development, Child and Youth Health (IHDCYH), IPPH and the CIHR Ethics Office.The objective of this program is: i) to address ethical, legal and social issues relevant to the design and conduct of population-based genetic epidemiological research, including implications for future studies in Canada, ii) while building research capacity in this field by providing an opportunity for new investigators to develop and demonstrate their independence in initiating and conducting health research. Results of this competition will be available in the fall of 2004.
Compelling Values: Privacy, Access to Data and Health Research Grants. Launched by CIHR's 13 Institutes and the CIHR Ethics Office, this program was designed to provide operating grant funds in support of initiatives that address issues related to the collection, use and disclosure of personal information for health research purposes. Eight applications were submitted to the October 2003 competition deadline.The IG is supporting two of the four applications approved for funding.
Encouraging Innovation
The IG re-launched two unique programs that focus on invention and high-risk/high-benefit projects in partnership with the Institute of Neurosciences, Mental Health and Addiction (Appendix 3).
Invention and Technology Application Grants: Tools,Techniques and Devices for Research and Medicine. An array of tools, techniques and methodologies currently employed in biomedical research are an integral part of hypothesis-driven projects. The invention and development of new research tools or techniques, or the improvement and application of existing ones, is often crucial and tightly linked to scientific discovery.This program is designed to promote the engagement of Canadian scientists in research projects to advance research tools and techniques in a broad sense, where invention, application and development, rather than discovery, is expected to be the essence of those projects. Results of the February 2004 competition will be available in the summer of 2004.
New Discoveries: High-Risk Seed Grants. The purpose of this program is to encourage novel, innovative, and inventive research. Successful applications will be unique, original, and/or extraordinary but of excellent quality and potential. The proposals are expected to i) be clearly novel and exciting to peer reviewers despite their inherent risk; and ii) demonstrate the potential for significant impact. Results of the February 2004 competition will be available in the summer of 2004.
Research Capacity Building
Building researcher capacity in targeted areas of importance is a key goal for the Institute. In support of this goal, the IG launched and/or funded seven RFAs during this reporting period aligned with four research priority themes (Appendix 3).
Population Genetics, Genetic Epidemiology, and Complexe Diseases
Population Genetics and Genetic Epidemiology of Complex Diseases Doctoral Research Awards and Fellowships. As part of a research capacity building effort, the IG and IPPH issued an RPA to fund Doctoral Research Awards and Fellowships from the fall 2003 CIHR competitions.The Research Priority Announcement (RPA) process enables Institutes to fund highly rated applications responsive to their priorities submitted to the CIHR open competitions. Results of these competitions will be available in spring 2004.This RPA was subsequently re-launched in December 2003 to fund Fellowships - in this area of investigation - submitted to the spring of 2004 CIHR competition.
Integrating the Physical & Applied Sciences into Health Research
"Integration of Mathematics, Statistics and Biophysics into Health Research" and "Integration of Fundamental Bioengineering into Biomedical Research" New Emerging Team (NET) Grant. This novel CIHR grants program has garnered much praise and enthusiasm from the research community.This program was developed: to build capacity in new and developing areas of research; to build new research teams; and to give researchers a building block for applying for research funding in future years.The IG joined the summer 2002 launch of the NET program and is supporting one team in each of the following research foci: Integration of Mathematics, Statistics and Biophysics into Biomedical Research and Integration of Fundamental Bioengineering into Biomedical Research.
One-year Bridging Operating Grants
The IG provided one-year bridging operating grants to excellent operating grants that were not funded through the CIHR open competition through the Research Priority Announcement (RPA) process from the March 2003 and September 2003 competitions (Appendix 3).
Workshop Support
During this reporting period, the IG committed approximately $140,000 towards funding 21 workshops and symposia (Appendix 4).
Regenerative Medicine and Nanomedicine Initiative: NETs and Interdisciplinary Capacity Enhancement (ICE) Research Team Grants. In partnership with the Institute of Neurosciences, Mental Health and Addiction (INMHA), the IG is co-leading the CIHR Regenerative Medicine and Nanomedicine Initiative, with a specific interest in nanomedicine relevant to the basic understanding, diagnosis and treatment of disease. Results of the February 2004 full application deadline will be announced in October 2004. Planning is underway for a June 2004 RFA re-launch.
Proteomics and Bioinformatics Training Program Grant in Bioinformatics. This program was developed by CIHR for the purpose of building capacity within Canada's health research community through the training and development of researchers, and fostering the development and ongoing support of the research careers of women and men in health research.
In May 2002, 51 new training programs were funded for a total investment of $85 million over six years. Of these, 15 training program grants were co-funded by the IG and partners (Appendix 3).These programs deliver unique training, creative curriculum, and often involve faculty from diverse disciplines and background.
The IG joined the summer 2002 launch of the CIHR Strategic Training Program Grants in Health Research Initiative. From this competition, the IG is supporting one training program grant in bioinformatics.
From Genes to Genomic Medicine (including Clinical Genetics Research)
In response to the research community, the IG has undertaken a range of activities to build research capacity and strengthen existing research communities in vibrant, innovative and stable research environments.
Clinical Investigatorship Awards. This program is aimed at enabling clinical geneticists to become successful clinical genetics investigators by providing two years of protected research time .The next competition deadline for this program is June 2004.
Drs.Walter and Jessie Boyd & Charles Scriver MD/PhD Studentships. This program, offered in partnership by the IG, the Canadian Gene Cure Foundation (CGCF) and the Canadian Genetic Diseases Network (CGDN), provides support for students enrolled in MD/PhD programs with a research focus in one of the following areas: genetics and genetic-related diseases (including medical genetics, bioinformatics, and bioethics of medical genetics); population genetics; translational genetics; and fundamental biochemical research in healthy and disease states.
The IG and its partners have committed $1.23 million over six years to ten MD/PhD Studentship Awards (as of fiscal year 2002-03). Currently, eight MD/PhD students are being supported by this program.The IG, CGCF and CGDN relaunched this program in December 2003 to allocted the remaining studentship awards.
Clinical Genetics Research Strategic Training Initiative in Health Research - Training Program Grants. The purpose of this initiative is to increase the number of clinical genetics investigators in Canada, by providing specialized clinical genetics research training opportunities. Results of the November 2003 competition will be available in the fall of 2004.
Assessment and Surveillance of Existing and Required Capacity
During the reporting period, the IG was involved in the hosting and sponsoring of four nation-wide stakeholder consultations and workshops in areas of strategic research priority:
Facilitating the work of Principal Investigators
Events
The Annual New Principal Investigators Meeting, the Biennial Developmental Biology Symposium and International Conference of the Canadian Proteomics Initiative are events that the IG has committed to support and foster on a continuous basis:
Annual New Principal Investigators (PI) Meeting. This annual event is organized by the IG, generally in partnership with another CIHR Institute, and is held in Jackson's Point, Ontario.The IG and INMHA sponsored and hosted the second annual meeting that took place November 14-16, 2003.The neuroscience-themed meeting was attended by over 100 outstanding researchers in their first four years of appointment in the fields of basic biochemistry, basic cell biology, genetics, developmental biology,
bioinformatics and ethics. Planning is underway for the third, fall 2004 meeting, in partnership with the Institute of Cancer Research (ICR).
Biennial Developmental Biology Symposium. During the reporting period planning was underway for this biennial event organized and sponsored by the IG. This symposium will include sessions focused on mechanisms of patterning, organogenesis, neuronal determination and synaptogenesis, stem cells and molecular mechanisms of human disease. It is anticipated that more that 250 researchers will attend the next meeting scheduled April 1-4, 2004, in Banff, Alberta.
International Conference of the Canadian Proteomics Initiative (CPI). CPI is part of a cross- Canada effort to build on Canada's growing strengths in the field of proteomics and protein chemistry.The international conference provides a general forum for disseminating the latest developments in proteomics and protein chemistry to Canadian scientists. It is a multidisciplinary conference that brings together approximately 250 researchers with expertise in all areas of proteomics including functional proteomics, structural proteomics, protein display, protein expression, protein chemistry and protein interactions. The IG will be sponsoring and participating at the 4th International Conference scheduled for May 14-16, 2004, in Montreal, Quebec.
Career Development Grants and Awards
Recognizing that researchers are attracted to areas of investigation within the mandate of the IG from a variety of disciplines, the IG has developed two innovative funding programs - unavailable through the existing national programs - that were relaunched during this reporting period: Short-Term Research Visit Grants and Career Transition Awards.
Short-Term Research Visit Grants. This program is intended to enable developing or established researchers to spend up to three months in a specific location focusing on the acquisition of new concepts, knowledge or techniques to broaden their research perspectives and skills that align with the IG's mandate. Results of the February 2003 and June 2003 competition are available in Appendix 3.
Career Transition Awards. This program is designed to support the career transition of faculty members who are planning to undertake rigorous training in identified areas of needs outside their primary research training and expertise. Results of the February 2004 competition will be available in the spring of 2004.This program is scheduled for re-launch in June 2004.
Developing National Platforms
Canadian Multi-Generational Birth-Cohort. A central initiative for the IG has been fostering the development of the Canadian Multi-Generational Birth-Cohort with IPPH, IHDCYH and partners (a major longitudinal and intergenerational study), including the exploration of GELS issues in partnership with the CIHR Ethics Office. This initiative aligns with the IG Population Genetics and Genetic Epidemiology of Genetically Complex Diseases Research Priority Theme. Key activities during the reporting period include:
In this context, four of the six IG research priority themes directly facilitate Knowledge Translation (KT) throughout the research process, promoting active exchange between the creators and users of knowledge to accelerate its capture into health benefits: Health Services for Genetic Diseases; From Genes to Genomic Medicine (including Clinical Genetics Research); Genetics and Ethical, Legal and Social Issues (GELS); and Integrating the Physical and Applied Sciences into Health Research.
Advancing Research in the Use of Health Knowledge
Strategies for Knowledge Translation. The IG participated in the 2002 and 2003 launching of the Strategies for Knowledge Translation RFA - led by the CIHR Knowledge Translation and Partnerships Portfolio - in support of genetic knowledge translation studies plus a specific call for proposals focused on the use of folic acid supplementation.
From the 2002 competition, the IG, IHSPR and the CIHR Knowledge Translation Portfolio have committed to fund two grants in support of genetic knowledge translation studies. In addition, the IG funded a knowledge translation research grant on the use of folic acid supplementation, in partnership with the Institute of Gender and Health and the CIHR Knowledge Translation Portfolio (Appendix 3). Results of the 2003 competition will be available at the end of 2004.
The Federal/Provincial/Territorial Task Force on Genomics and Health, the IHSPR and the IG collaborated to facilitate the linkages between policy makers and researchers who submitted applications to the Staying Ahead of the Wave: Genetics, Health Services and Health Policy RFA.
Knowledge Translation (KT) is the exchange, synthesis and ethically-sound application of knowledge-within a complex system of interactions among researchers and users-to accelerate the capture of benefits of research for Canadians through health, more effective services and products and a strengthened health care system. (Definition adopted by CIHR)
As evidenced throughout this report, the IG collaborated with other Institutes,Voluntary Health Organizations and government to build on the IG strengths and capitalize on Canada's health research investment.
Voluntary Health Organizations (VHO)
The IG VHO Working Group has been established to cultivate a full partnership between VHOs and the IG to influence an integrative health research institute and to promote public engagement among the stakeholders in the work of CIHR.The Working Group's efforts in 2003-04 included the consideration of hosting a Partners Symposium to explore facilitating funding the best research with a minimum overlap of effort, particularly in the review of applications.
International
The IG and CGDN International Collaborations in Human Genetics Priority & Planning (P&P) Committee's mandate is to identify areas of research that are synergistic between two countries and will lead to meaningful research collaborations. Examples of the committee's efforts in fiscal year 2003-04 include:
Promoting Science to Canadian Youth
The "Be a Gene Researcher for a Week" Program. The IG co-sponsored the "Be A Gene Researcher for a Week-the Ramon Hnatyshyn Youth in Science Initiative" (in partnership with CGDN). This nation-wide training program in genetics provided 31 high school students the opportunity to spend their spring break in a CGDN/IG research environment. Planning is underway to relaunch this program for Spring Break 2005.
The Geee! In Genome. Opening in Ottawa (April 2003), this travelling museum exhibit is an innovative, multi-dimensional public education project developed by the Canadian Museum of Nature in partnership with Genome Canada and CIHR. In addition to participating on the concept design team, the IG has contributed to the planning of activities associated with this national touring exhibit.
The accomplishments of the IG during this reporting period toward building a national health research agenda in genetics, basic biochemistry and basic cell biology are a direct reflection of the dedication, commitment and collaborative involvement of the Scientific Director, the Institute Advisory Board, the P&P Committees and VHO Working Group and IG staff.
Institute Advisory Board
Institute Advisory Board members provide invaluable assistance and advice with the development and implementation of the IG's research priority-setting process. In addition to participating actively on P&P Committees, IAB members meet at least twice a year to discuss the activities of the IG's research priorities.
Priority & Planning (P&P) Committees and VHO Working Group
The 12 P&P Committees and VHO Working Group are integral to the IG's ability to carry out its mandate (Appendix 2).The P&P Committee for each research priority theme gathers input from that research community regarding research priorities.Additional P&P Committees and the VHO Working Group enable IG development in other critical areas, such as international collaborations in human genetics, public engagement, knowledge exchange and new principal investigators.
These P&P Committees and the VHO Working Group present recommendations to the IAB for discussion and funding consideration.Through this process, over 100 leading researchers and committed stakeholders regularly inform and advance the IG's genetic, basic biochemistry and basic cell biology health research agenda.
Figure 2
Organizational Structure of the Institute of Genetics
Scientific Director and IG Staff
Operationally, the IG is supported by teams based at The Hospital for Sick Children in Toronto and the CIHR Secretariate in Ottawa.
| Toronto | Ottawa |
| Scientific Director Roderick R. McInnes, MD, PhD Tel: (416) 813-7400 Fax: (416) 813-7673 rodig@sickkids.ca |
Assistant Director, Ottawa Stephanie Robertson, MA Tel: (613) 954-0533 Fax: (613) 941-1800 srobertson@cihr-irsc.gc.ca |
| Assistant Director Milka Popov, PhD Tel: (416) 813-7670 Fax: (416) 813-7673 mpopov@sickkids.ca |
Institute Project Officer Amanda Devost Tel: (613) 941-0997 Fax: (613) 941-1800 adevost@cihr-irsc.gc.ca |
| Assistant Director (Acting 09/03 - 08/04) Nicola McDermott, MSc Tel: (416) 813-7670 Fax: (416) 813-7673 nickyig@sickkids.ca |
Students - Toronto |
| Executive Assistant and Project Manager Jennifer Jennings, BA Tel: (416) 813-7400 Fax: (416) 813-7673 jennig@sickkids.ca |
Clayton Cheng Tel: (416) 813-7672 Fax: (416) 813-7673 adminig@sickkids.ca |
| Administrative Assistant Esther Berzunza, BA Tel: (416) 813-7671 Fax: (416) 813-7673 estherig@sickkids.ca |
Scott Tanaka Tel: (416) 813-7672 Fax: (416) 813-7673 adminig@sickkids.ca |
Mailing Addresses
| CIHR Institute of Genetics 123 Edward Street, Suite 1211 Toronto, ON M5G 1E3 |
CIHR Corporate Headquarters 160 Elgin Street, 9th Floor,Address Locator 4809A Ottawa, ON K1A 0W9 |
For the year ending March 31, 2004
| Available Funds | $1,322,124.65 |
| EXPENSES | |
| Institute Development | |
| Conferences, symposia and workshops | $490,076.94 |
| Institute Advisory Board Meetings | 50,402.00 |
| Professional Services | 79,428.00 |
| Other Costs | 96,857.40 |
| $716,765.13 | |
| Institute Operations | |
| Salaries and benefits | $464,750.43 |
| Office accommodations | 16,165.00 |
| Telephone and communication services | 9,192.49 |
| Supplies, materials and other services | 13,170.94 |
| Computer equipment and IT support | 11,364.38 |
| Professional services | 1,011.90 |
| Travel expenditures | 52,499.05 |
| Other expenditures | 7,433.64 |
| $575,587.87 | |
| TOTAL EXPENSES | $1,292,353.00 |
| UNSPENT BALANCE | * $29,722.00 |
* Note: The unspent balance as at March 31, 2004 is carried forward to the subsequent fiscal year
Contributions through Grants and Awards For the year ending March 31, 2004
| Strategic Initiatives | Number | 2003-04 | 2004-05 | 2005-06 | 2006 and Beyond | Total |
| Career Transition Awards | 5 | 185,000 | - | - | - | 185,000 |
| Celera Genome Database Grants | 5 | 84,120 | - | - | - | 84,120 |
| Clinical Investigatorship Awards | 2 | 240,000 | 120,000 | - | - | 360,000 |
| Compeling Values: Privacy Access to Data and Health Research Grants | 2 | - | 65,672 | 9,381 | - | 75,053 |
| Facing our Future: Human genetics, Ethics, Law and Society Development Grants | 6 | 124,715 | - | - | - | 124,715 |
| Interdisciplinary Capacity Enhancement (ICE) Teams | 2 | 194,618 | 199,753 | 199,947 | 349,718 | 944,036 |
| Interdisciplinary Health Research Team (IHRT) Top-up Funding | 3 | 154,087 | - | - | - | 154,087 |
| Invention and technology Application Grants: Tools, techniques and Devices for Research and Medicine | 4 | 331,045 | 331,045 | 303,459 | - | 965,549 |
| Knowledge Translation Grants | 3 | 70,740 | 63,926 | 8,334 | - | 143,000 |
| NET: Gene-Environment and Obesity | 1 | 25,000 | 25,000 | 25,000 | 50,000 | 125,000 |
| NET: Genomics and Aging | 1 | 25,000 | 25,000 | 25,000 | 50,000 | 125,000 |
| NET: Integration of Fundamental Bioengineering into Health Research | 1 | 300,000 | 300,000 | 300,000 | 600,000 | 1,500,000 |
| NET: Integration of Mathematics, Statistics and Biophysics into Health Research | 1 | 300,000 | 300,000 | 300,000 | 600,000 | 1,500,000 |
| New Discoveries: High-Risk Seed Grants | 4 | 207,376 | 204,147 | - | - | 411,523 |
| Novel Population Genetics and Genetic Epidemiological Methods from Studies of Complex Genetic Diseases Grants | 4 | 128,545 | 144,353 | 128,608 | 30,710 | 432,216 |
| One-Year Bridging Fellowships | 4 | 99,875 | - | - | - | 99,875 |
| One-Year Bridigng Operating Grants | 23 | 1,241,351 | 1,090,536 | - | - | 2,331,887 |
| Short-Term Research Visit Grants | 21 | 96,312 | - | - | - | 96,312 |
| Staying Ahead of the Wave: Genetics, Health Services and Health Policy Development Grants | 3 | 112,089 | - | - | - | 112,089 |
| Strategic Training Program Grants | 16 | 1,286,290 | 1,448,170 | 1,448,170 | 3,042,757 | 7,225,387 |
| Walter and Jessie Boyd & Charles Scriver MD/PhD Studentship Awards | 8 | 70,333 | 82,000 | 73,417 | 171,000 | 396,750 |
| Total | 111 | 5,206,163 | 4,399,602 | 2,821,316 | 4,894,185 | 17,391,599 |
Note: Grants and awards in respect to these programs are approved for 1 to 6 years. Figures displayed represent CIHR financial commitments for these programs in 2003-04 and subsequent years.Availability of these funds in future years are subject to funding appropriations by Parliament. For some initiatives, partners also contributed to the funding of the grants and awards.
Institute of Genetics Advisory Board Membership
| Joel Weiner, PhD (Chair) University of Alberta |
Janet Rossant, PhD University of Toronto |
| François Rousseau, MD (Vice-Chair) Université Laval |
Michael Snyder, PhD Yale University |
| Judith Allanson, MD Children's Hospital of Eastern Ontario |
Andrew Storer, PhD National Research Council of Canada |
| Michel Bouvier, PhD Université de Montréal |
Caroline Weber Health Canada |
| Jacques Drouin, DSc Institut de recherches cliniques de Montréal |
Former Members (Term end: August 2004) |
| Béatrice Godard, PhD Université de Montréal |
James McGhee, PhD University of Calgary |
| Jane Green, PhD Memorial University of Newfoundland |
Robert Peterson, MD, PhD, MPH Health Canada |
| Michael Hayden, MB, ChB, PhD University of British Columbia |
Natalie Strynadka, PhD University of British Columbia |
| Philip Hieter, PhD University of British Columbia |
Julien Veilleux, CPMQ, CRMCC Ministère de la santé et des services sociaux |
| Tom Hudson, PhD McGill University |
Ex Officio Members |
| Margaret Lock, PhD McGill University |
Françoise Baylis, PhD Dalhousie University Philippe Gros, PhD McGill University |
| Daryl Pullman Memorial University of Newfoundland |
Alexander MacKenzie, MD Genome Canada Joseph Rotman CIHR Governing Council |
Institute of Genetics Priority and Planning Committees Memership
A. Committees Supporting the IG Research Priority Themes
Bioinformatics
Peter Lewis, University of Toronto (Co-Chair)
Francis Ouellette, University of British Columbia (Co-Chair)
Fiona Brinkman, Simon Fraser University
William Crosby, University of Saskatchewan
Steven Jones, British Columbia Cancer Agency
Paul Kearney, University of Waterloo
François Major, University of Montreal
Andrew Roger, Dalhousie University
Christoph Sensen, University of Calgary
Chris Upton, University of Victoria
From Genes to Genomic Medicine (including Clinical Genetics Research)
Jan Friedman, University of British Columbia (Co-Chair)
Peter St. George-Hyslop, University of Toronto (Co-Chair)
Jane Evans, University of Manitoba
Blair Leavitt, University of British Columbia
Alex MacKenzie, Children's Hospital of Eastern Ontario
Jacques Michaud, Hôpital Ste-Justine
David Rosenblatt, McGill University
Jacques Simard, Université Laval
Rosanna Weksberg, Hospital for Sick Children
Population Genetics, Genetic Epidemiology, and Complexe Diseases
Shelley Bull, Samuel Lunenfeld Research Institute (Co-Chair)
Kenneth Morgan, Montreal General Hospital (Co-Chair)
Robert Brunham, University of British Columbia
Gail Eyssen, University of Toronto
France Gagnon, University of Ottawa
Jinko Graham, Simon Fraser University
Jane Green, Memorial University of Newfoundland
Celia Greenwood, Hospital for Sick Children
Robert Hegele, University of Western Ontario
Claude Laberge, Université Laval
John McLaughlin, Samuel Lunenfeld Research Institute
Bruce Rannala, University of Alberta
Genetics and Ethical, Legal and Social Issues
Tim Caulfield, University of Alberta (Co-Chair)
Margaret Lock, Université de McGill (Co-Chair)
Laura Arbour, University of British Columbia
Françoise Baylis, Dalhousie University (ex officio)
Abdallah Daar, University of Toronto
Jane Evans, University of Manitoba
Béatrice Godard, Université de Montréal
Patricia Kosseim, CIHR Ethics Office (ex officio)
Trudo Lemmens, University of Toronto
Daryl Pullman, Memorial University of Newfoundland
Health Services for Genetic Disease (with IHSPR)
Judith Allanson, Children's Hospital of Eastern Ontario (Co-Chair)
Eva Grunfeld, Ottawa Regional Cancer Centre (Co-Chair)
Denise Avard, Université de Montréal
Mario Cappelli, Children's Hospital of Eastern Ontario
June Carroll, Mount Sinai Hospital
Tim Caulfield, University of Alberta
Christine Kennedy, University of Calgary
François Rousseau, Université Laval
Brenda Wilson, University of Ottawa
Integrating the Physical and Applied Sciences into Health Research
Philip Hieter, University of British Columbia (Co-Chair)
Christopher Yip, University of Toronto (Co-Chair)
Brenda Andrews, University of Toronto
John-Bruce Green, University of Alberta
Charles Haynes, University of British Columbia
Yves de Koninck, Université Laval
Proteomics
Joel Weiner, University of Alberta (Chair)
Brenda Andrews, University of Toronto
John Bergeron, McGill University
Mirek Cygler, National Research Council Canada
Michel Desjardins, Université de Montréal
Peter Lewis, University of Toronto
Mike Moran, MDS Proteomics
Natalie Strynadka, University of British Columbia
Hans Vogel, University of Calgary
David Wishart, University of Alberta
Steve Withers, University of British Columbia
B. Committees Supporting the IG Enabling Strategies
Cell Biology (under development)
Richard Rachubinski, University of Alberta (Chair)
Developmental Genetics and Birth Defects
Jacques Drouin, Institut de recherches cliniques de Montréal (Chair)
Paul Lasko, McGill University
Howard Lipshitz, Hospital for Sick Children
James McGhee, University of Calgary
Jacques Michaud, Hôpital Ste. Justine
Janet Rossant, Samuel Lunenfeld Research Institute
International Collaborations in Human Genetics (with CGDN)
Stephen Scherer, Hospital for Sick Children (Chair)
Diane Cox, University of Alberta
Louise Desjardins, Canadian Genetic Diseases Network
Bartha Knoppers, Université de Montréal
Robert Korneluk, Children's Hospital of Eastern Ontario
François Rousseau, Université Laval
New Principal Investigators
Geoff Hicks, University of Manitoba (Chair)
Susan Andrew, University of Alberta
Benoit Bruneau, Hospital for Sick Children
Benedikt Fischer, University of Toronto
Nancy Hawkins, Simon Fraser University
Ridha Joober, Douglas Hospital Research Centre
Jason Robert, Dalhousie University
Jane Roskams, University of British Columbia
Public Engagement and Knowledge Exchange
François Rousseau, Université Laval (Chair)
Jane Green, Memorial University of Newfoundland
Michael Hayden, University of British Columbia
Voluntary Health Organizations Working Group
Teren Clarke, Muscular Dystrophy Association of Canada (Chair)
Nancy Amos, CIHR Partnerships Branch
Sharon Colle, Foundation Fighting Blindness-Canada
Judi Farrell, Lupus Canada
Isla Horvath, Huntington Society of Canada
Jason Robert, Dalhousie University
Alison Stephen, Heart and Stroke Foundation of Canada
Doretta Thompson,ALS Society of Canada
RFAs launched and/or under review during fiscal year 2003-2004
| Program | Description | Competition Deadline | Funding Start Date |
| Outstanding Research | |||
| Addressing Health Care and Health Policy Challenges of New Genetic Opportunities Grant (in partnership with IHSPR, IPPH, Canadian Coordinating Office for Health Technology Assessment, Heart and Stroke Foundation, Federal/Provincial/Territorial Task Group on Genomics and Health) | Providing operating grant funds in support of research projects, the results of which will better equip health care providers, administrators and policy makers to improve the health of populations and strengthen the health care system in Canada | June 2004 | November 2004 |
| Facing our Future: Human Genetics, Ethics, Law and Society Development Grant Second Competition (in partnership with IPPH, IA, IHDCYH) | Support critical analysis of current ethical, legal and social practices involving population-based genetic research as well as implications for future studies in Canada | May 2004 | December 2005 |
| Invention and Technology Application Grants-Tools,Techniques and Devices for research and Medicine (in partnership with INMHA) | Promote the engagement of Canadian scientists in research projects to advance research tools and techniques in a broad sense, where invention and development, rather than discovery, is expected to be the essence of those projects | February 2004 | July 2004 |
| New Discoveries: High-Risk Seed Grants (in partnership with INMHA) | Encourage novel, innovative and inventive research | February 2004 | July 2004 |
| Population Genetics and Genetic Epidemiology of Complex Diseases Operating Grants (in partnership with IPPH) | As part of the Canadian Lifelong Health Initiative, the IG developed this program to provide support to investigators in the area of complex genetic diseases | March 2004 | October 2004 |
| Oustanding Researchers in Innovative Environments | |||
| Career Transition Awards | Support career transition of faculty members who are planning to undertake rigorous training outside of their primary area of expertise | February 2004 | July 2004 |
| Clinical Genetics Research Strategic Training Program Grants | Build the capacity of the Canadian health research community by training and supporting young talent | November 2003 | October 2004 |
| Clinical Investigatorship Awards | Provides two years of protected research time to pursue clinical or translational research | June 2004 | October 2004 |
| One-Year Bridging Operating Grants | These grants fund any application where the Institute of Genetics (IG) was indicated as the primary or secondary affiliated Institute and relates to the IG mandate. Grants are offered as one-time, non-renewable, one-year bridging grants | September 2003 March 2004 |
April 2004 October 2004 |
| Population Genetics and Genetic Epidemiology of Complex Diseases Doctoral Research Awards and Fellowships (in partnerhsip with IPPH) | As part of the Canadian Lifelong Health Initiative, the IG developed this program to provide support to investigators in the area of complex genetic diseases | Fall 2003 Spring 2004 |
April 2004 July 2004 |
| Regenerative Medicine and Nanomedicine Initiative: NETs and Interdisciplinary Capacity Enhancement (ICE) Research Teams in the area of nanomedicine (in partnership with INMHA) |
IG research focus-nanotechnology: Support for nanomedicine in this strategic initiative is directed in large part towards the development of technology relevant to basic understanding, diagnosis, or treatment of disease, emphasizing the integration and application of the physical, engineering, and chemical sciences with the biosciences | February 2004 | October 2004 |
| Regenerative Medicine and Nanomedicine: Innovative Approaches in Health Research-Team Grant Program and High-Risk Seed Grants | This strategic initiative announcement provides support for research in nanomedicine and technology development, gene therapy, stem cells, tissue engineering, and rehabilitation sciences |
May 2005 | October 2005 |
| Short-Term Research Visit Grants | Facilitate cross-disciplinary training by giving health researchers financial support for short-term visits (three months or less) to research centers within Canada and abroad | October 2003 February 2004 |
January 2004 May 2004 |
| Walter and Jessie Boyd & Charles Scriver MD/PhD Studentships (in partnership with the Canadian Gene Cure Foundation and the Canadian Genetic Diseases Network) | Provides support for MD/PhD students with a research focus in the areas of genetics | June 2004 | September 2004 |
Competition Results: Request for Applications (RFAs)
NOTE.The financial amounts reflected in this appendix represent the (a) financial contribution and (b) term at the time that the grant/award was offered by the IG. For specific amounts paid out during the reporting period, please refer to the "Investments in Strategic Initiatives" table.
Fostering Research
Population Genetics, Genetic Epidemiology, and Complex Diseases
| Novel Population Genetic and Genetic Epidemiological Methods for Studies of Complex Genetic Diseases in partnership with the Institute of Population and Public Health (IPPH) | ||||
| Summary | Competition Deadline | Applications Received (#) | Applications Approved (#) | Success Rate (%) |
| This program was designed to support individuals or teams to develop new theories, strategies and methodologies needed to facilitate more conclusive, high-quality etiological studies of such diseases. | December 2002 | 12 | 4 | 33 |
| Grantee(s): | ||||
| BRIOLLAIS, Laurent Mount Sinai Hospital KOPCIUK, Karen Alberta Cancer Board |
Statistical methods and study designs for penetrance estimation of genes involved in complex diseases | $196,050 over three years | ||
| BULL, Shelley Samuel Lunenfeld Research Institute SUN, Lei University of Toronto |
Statistical methods to improve the reliability of results from genome-wide studies of complex disease and quantitative traits | $251,780 over three years | ||
| GRAHAM, Jinko Simon Fraser University MCNENEY,William Bradley Simon Fraser University |
Statistical methods for simultaneous estimation of haplotypes and haplotype and environmental risks in association studies of complex genetic diseases | $174,000 over three years | ||
| GREENWOOD, Celia Hospital for Sick Children BEYENE, Joseph University of Toronto |
Multi-level modeling in linkage and association analysis | $242,600 over three years | ||
Health Services for Genetic Diseases
| Staying ahead of the Wave: Genetics, Health Services and Health Policy Development Grant in Parntership with the Institute of Health Services and Policy Research (IHSPR) | ||||
| Summary | Competition Deadline | Applications Received (#) | Applications Approved (#) | Success Rate (%) |
| This program was designed to provide development funds in support of initiatives likely to lead to longer term research proposals or programs of inquiry to address the most important, emerging issues facing the Canadian health care system in response to new understandings about human genetics, and the burgeoning of genetic information, technologies, products and services. | January 2003 | 10 | 3 | 30 |
| Grantee(s): | ||||
| AVARD, Denise Université de Montréal |
Storage of dried blood spots: Genetic, health services and research policy implications | $75,000 over one year | ||
| CAPPELLI, Mario Children's Hospital of Eastern Ontario ESPLEN, Mary University of Toronto |
Psychosocial health service implications for genetic testing: A clinical and training needs assessment | $74,245 over one year | ||
| MILLER, Fiona McMaster University WEKSBERG, Rosanna The Hospital for Sick Children |
Evaluation and priority setting for genetic services: A case study | $74,931 over one year | ||
Genetics and Ethical, Legal and Social Issues
| Compelling Values: Privacy,Access to Data and Health Research in partnership with CIHR's 13 Institutes and the CIHR Ethics Office | ||||
| Summary | Competition Deadline | Applications Received (#) | Applications Approved (#) | Success Rate (%) |
| This program was designed to provide operating grant funds in support of initiatives that address issues related to collection, use and disclosure of personal information for health research purposes. | October 2003 | 8 | 4 (2 are supported by the IG) |
50 |
| Grantee(s): | ||||
|
UPSHUR, Ross; |
The collection, use and disclosure of personal health information: The health care information directive applied to genetics | $40,807 over two years | ||
| WILLISON, Donald McMaster University |
Understanding Canadians' attitudes and expectations re: privacy, access to data, and health research-A comparison of survey and citizens' dialogue methods | $199,226 over two year | ||
Research Capacity Building
From Genes to Genomic Medicine (including Clinical Genetics Research)
| Walter and Jessie Boyd & Charles Scriver MD/PhD Studentships in partnership with the Canadian Gene Cure Foundation and the Canadian Genetics Diseases Network | ||||
| Summary | Competition Deadline | Applications Received (#) | Applications Approved (#) | Success Rate (%) |
| This award provides support for students enrolled in the MD/PhD training program whose research focus is in the areas of genetics and genetic-related diseases. | July 2003 | 2 | 2 | 100 |
| Grantee(s): | ||||
| HYDE,Angela Memorial University of Newfoundland |
The molecular characterization of colorectal cancer in Newfoundland | $123,000 over six years | ||
| WARD, Michael University of Toronto |
Genetic and functional studies for primary pulmonary hypertension | $123,00 over six years | ||
Integrating the Physical and Applied Sciences into Health Research
| Integration of Mathematics, Statistics and Biophysics into Health Researchm New Emerging Teams (NETs) | ||||
| Summary | Competition Deadline | Applications Received (#) | Applications Approved (#) | Success Rate (%) |
| This initiative was designed to build capacity in this new and developing area of research and to build new research teams. | January 2003 | 2 | 1 | 50 |
| Grantee(s): | ||||
| ESCOBAR, Michael University of Toronto |
Modern statistical approaches in high-throughput genomic research | $1,500,000 over five years | ||
| Integration of Fundamental Bioengineering into Health Research New Emerging Teams (NETS) | ||||
| Summary | Competition Deadline | Applications Received (#) | Applications Approved (#) | Success Rate (%) |
| This initiative was designed to build capacity in this new and developing area of research and to build new research teams. | January 2003 | 1 | 1 | 100 |
| Grantee(s): | ||||
| PILARSKI, Linda Cross Cancer Institute |
Novel platforms for genetic analysis | $1,500,000 over five years | ||
| Strategic Training Program Grants in Bioinformatics | ||||
| Summary | Competition Deadline |
Applications Received (#) | Applications Approved (#) | Success Rate (%) |
| The IG is using this program to build capacity within Canada's bioinformatics research community through the training and development of researchers, and fostering the development and ongoing support of the research careers of women and men in health research. |
January 2003 | 2 | 1 | 50 |
| Grantee(s): | ||||
| BURGER, Gertraud Université de Montréal |
Bioinformatics training for biomedical research | $1,800,000 over six years | ||
Facilitating the Work of Principal Investigators
| Short-Term Research Visit Grants | ||||
| Summary | Competition Deadline | Applications Received (#) | Applications Approved (#) | Success Rate (%) |
| These grants are inteded to faciliate cross-disciplinary training by giving health researchers financial support for short-term visits (three months or less) to research centers within Canada and abroad | February 2003 June 2003 |
27 5 |
17 3 |
63 60 |
| Competition: February 2003 | ||||
| Grantee(s): | ||||
| ANDERSEN, Marilyn University of British Columbia |
Workshop that will provide training to aid in the creation of integrated databases | $2,600 up to three months | ||
| BALABANIAN, Sylvia University of Ottawa |
Canadian bioinformatics workshop | $2,600 up to three months | ||
| BRAZAS, Michelle University of British Columbia |
High-throughput analysis of the antibiotic resistance mechanisms in PSeudomonas aeurginosa | $1,600 up to three months | ||
| BROWN, Carolyn University of British Columbia |
XIST RNA localization and function in X chromosome inactivation | $11,000 up to three months | ||
| BYERS, David Dalhousie University |
Functional proteomics of natively-unfolded proteins: MARCKS and ACP | $7,190 up to three months | ||
| DA SILVA, Melissa University of Victoria |
Canadian bioinformatics workshop | $4,429 up to three months | ||
| HOLMES, Christina Dalhousie University |
Science, controversy, and genetically modified plants Participant observation of the creation of new genetic knowledge and edible vaccines | $5,375 up to three months | ||
| HOWARD, Heidi Montreal General Hospital |
Canadian bioinformatics workshop | $2,600 up to three months | ||
| MAYNES, Jason University of Alberta |
Applying unphased x-ray crystallographic data to the prediction of protein structures from mycrobacterium tuberculosis | $4,000 up to three months | ||
| MCGHEE, James University of Calgary |
Bioinformatic analysis of the complete transcript inventory of the C. elegans intestine | $2,250 up to three months | ||
| MEIJER, Inge Individuals Inside Canada |
Canadian bioinformatics workshop | $3,100 up to three months | ||
| RUDICH,Assaf Hospital for Sick Children |
Canadian bioinformatics workshop | $3,000 up to three months | ||
| SHAEPF, Manuela University of British Columbia |
Canadian bioinformatics workshop | $1,600 up to three months | ||
| VERLAAN, Domonique Canadian Genetic Diseases Network |
Canadian bioinformatics workshop | $5,265 up to three months | ||
| WEIJER, Charles Dalhousie University |
Towards a synthesis of the ethics and epistemology of clinical research | $9,995 up to three months | ||
| WILHELM, Brian University of British Columbia |
Canadian bioinformatics workshop | $6,800 up to three months | ||
| ZHU, Chang Qi University of Toronto |
Lung cancer genomic investigation using BAC (Bacterial Artificial Chromosome) array | $6,000 up to three months | ||
| Competition: June 2003 | ||||
| Grantee(s): | ||||
| CAMPBELL, Maria University of Alberta |
Canadian bioinformatics workshop | $3,000 up to three months | ||
| GRANT, Jason University of British Columbia |
Canadian bioinformatics workshop | $3,000 up to three months | ||
| MARCARDIER, Julien Hospital for Sick Children |
Single molecule analysis of DNA replication dynamics at the mytonic dystrophy Locus in patient cells | $4,600 up to three months | ||
| One-Year Bridging Operating Grants | ||||
| Competition: September 2002 | ||||
| Grantee(s): | ||||
| BOGGS, Joan Hospital for Sick Children |
Structural mechanism of osmosensing by osmosensor and osmoregulatory transporter prop of Escherichia coli | $92,858 over one year | ||
| CASEY, Joseph (Joe) University of Alberta |
Molecular physiology of sodium/bicarbonate co-transporters | $100,000 over one year | ||
| IGDOURA, Suleiman McMaster University |
Role of sialidase in the pathogenesis of neurodegenerative diseases | $100,000 over one year | ||
| KHANDIJAN, Edward Université Laval |
Function of the FMR1gene product in protein synthesis | $77,335 over one year | ||
| KHOKHA, Rama Ontario Cancer Institute |
Role of TIMP-3 in progression of cardiovascular disease | $75,330 over one year | ||
| MCBRIDE, Heidi University of Ottawa Heart Institute |
The role of sumo1 conjugation in the regulation of mitochondrial morphology | $75,332 over one year | ||
| MELACINI, Giuseppe McMaster University |
Structural basis for the cyclic AMP-signal translation in PKA by nuclear magnetic resonance | $77,809 over one year | ||
| MYMRYK, Joseph London Regional Cancer Centre |
Molecular genetic analysis of adenovirus E1A function | $94,454 over one year | ||
| OSBORNE, Lucy University of Toronto |
Understanding the molecular basis of Williams-Beuren syndrome | $78,433 over one year | ||
| SIMPSON, Elizabeth University of British Columbia |
Genetic and in-vivo studies to define the role of nr2el in aggressive behaviour | $86,318 over one year | ||
| YIP, Christopher University of Toronto |
Direct measurement of protein-protein interactions by force microscopy | $55,890 over one year | ||
| Competition: March 2003 | ||||
| Grantee(s): | ||||
| ENGERT, James Royal Victoria Hospital |
Linkage and association studies in a Quebec heart disease population | $89,836 over one year | ||
| PRIVE, Gilbert University Health Network |
Structure and function of saposin proteins | $81,270 over one year | ||
| RAK, Janusz McMaster University |
Tissue factor in tumour progression and angiogenesis | $93,250 over one year | ||
| RIGGS, Kenneth University of British Columbia |
The role of enzyme single nucleotide polymorphisms in the metabolism of anthracyclines | $74,403 over one year | ||
| SWEEZEY, Neil Hospital for Sick Children |
Glucocorticoid receptor and glucocorticoid-responsive genes in developing lung | $90,472 over one year | ||
| TESSON, Frédérique University of Ottawa Heart Institute |
Genetic approach to heart failure | $138,561 over one year | ||
| ZANNIS-HADJOPOULOS, Maria McGill University |
Characterization of mammalian origins of DNA replication and interacting factors | $142,430 over one year | ||
Financial Commitments incurred in Fiscal Year 2003-2004 from a previous reporting period
NOTE.The financial amounts reflected in this appendix represent the (a) financial contribution and (b) term at the time that the grant/award was offered by the IG. For specific amounts paid out during the reporting period, please refer to the "Investments in Strategic Initiatives" table.
Fostering Research
| Invention and Technology Application Grants - Tools,Techniques and Devices for Research and Medicine | ||||
| Summary | Competition Deadline | Applications Received (#) | Applications Approved (#) | Success Rate (%) |
| This program is designed to promote the engagement of Canadian scientists in research projects to advance research tools and techniques in a broad sense, where invention and development, rather than discovery, is expected to be the essence of those projects. | October 2002 | 23 (8 IG related) |
11 (4 IG related) |
50 |
| Grantee(s): | ||||
| HU, Jim Hospital for Sick Children |
A new genetic tool for mutational analysis of genes in mammalian cells and in animals | $294,017 over three years | ||
| KAST, Juergen University of British Columbia |
Development of a mass spectrometry-based method for full length sequencing of proteins | $283,386 over three years | ||
| RANCOURT, Derrick University of Calgary |
Development of a mouse gene rheostat | $286,710 over three years | ||
| WOOLLEY,Andrew University of Toronto |
Fluorescent tools for detecting protein-protein interactions | $135,880 over three years | ||
| New Discoveries - High-Risk Seed Grants | ||||
| Summary | Competition Deadline | Applications Received (#) | Applications Approved (#) | Success Rate (%) |
| The purpose of this New Discoveries- Seed Grants program is to encourage novel, innovative, and inventive research. | October 2002 | 10 (8 IG related) |
5 (4 IG related) |
50 |
| Grantee(s): | ||||
| BARKER, Philip Montreal Neurological Institute |
MAGE genes and Autism | $114,000 over two years | ||
| BOOTH, Stephanie Canadian Science Centre for Human and Annimal Health SOMORJAI, Rajmund Institute for Biodiagnostics, NRC |
Microarray expression profiling in prion induced neurodegenerative diseases using novel statistical classification strategies | $119,252 over two years | ||
| TIELEMAN, Dirk University of Calgary |
Computer modeling of ABC-transporter domains | $77,500 over two years | ||
| WOOLLEY,Andrew University of Toronto |
Fluorescence imaging of ion channels in action | $104,000 over two years | ||
| Facing our Future: Human Genetics, Ethics, Law and Society in partnership with IA & IPPH | ||||
| Summary | Competition Deadline | Applications Received (#) | Applications Approved (#) | Success Rate (%) |
| This initiative will support critical analysis of current ethical, legal and social practices involving population based genetic research as well as implications for future studies in Canada. | November 2002 | 11 | 6 | 55 |
| Grantee(s): | ||||
| HOY, Michael University of Guelph |
Impact on consumer welfare of genetic testing in insurance markets | $35,000 over one year | ||
| KNOPPERS, Bartha Université de Montréal |
Towards a common language for biobanking? | $28,600 over one year | ||
| LEE, Robert Calgary Health Region |
A systematic review of the social, ethical, and legal dimensions of genomic and proteomic cancer risk assessment and screening technologies | $34,300 over one year | ||
| LOCK, Margaret McGill University |
The consumer DNA profiling industry:The production of bodily commodities, explanatory narratives and uncertainty | $40,237 over one year | ||
| MILLER, Fiona McMaster University PULLMAN, Daryl Memorial University of Newfoundland |
Re-defining disease: Molecular genetics, ethics and health system implications | $74,960 over one year | ||
| LATUS,Andrew Memorial University of Newfoundland |
Benefit sharing: Commercial sponsors' perspectives | $34,900 over one year | ||
Research Capacity Building
| Clinical Investigatorship | ||||
| Summary | Competition Deadline | Applications Received (#) | Applications Approved (#) |
Success Rate (%) |
| This award provides two years of protected research time to pursue clinical or translational research. | July 2002 | 4 | 2 | 50 |
| Awardee(s): | ||||
| ARBOUR, Laura University of British Columbia |
The genetic and environmental bases of two complex diseases in the First Nations People of British Columbia | $240,000 over two years | ||
| LEWIS, Suzanne University of British Columbia |
New approaches toward understanding the genetic bases of form function and phenotype in Autism Spectrum Disorder | $240,000 over two years | ||
| Interdisciplinary Capacity Enhancement (ICE) Teams Grant Program in partnership with IHSPR | ||||
| Summary | Competition Deadline | Applications Received (#) | Applications Approved (#) | Success Rate (%) |
| These grants will enhance the capacity of groups of researchers to: (a) create strong intra- and interinstitution mentoring arrangements, and (b) developing knowledge translation. | October 2002 | 3 | 2 | 66 |
| Grantee(s): | ||||
| BATTISTA, Renaldo McGill University |
Genetic health policy support research program-to promote quality, efficiency and social well-being | $1,000,000 over five years | ||
| WILSON, Brenda University of Ottawa CAUFIELD, Timothy University of Alberta WELLS, George University of Ottawa |
Translating genetics discoveries into appropriate health policy and services: Enhancing research capacity and developing an interdisciplinary approach | $998,668 over five years | ||
| Strategic Training Program | Partners: | |
| Alberta Heritage Foundation for Health Research Canadian Institutes of Health Research (CIHR) Heart and Stroke Foundation of Canada Institute of Aboriginal Peoples' Health Institute of Cancer Research Institute of Circulatory and Respiratory Health Institute of Gender and Health Institute of Genetics Institute of Health Services and Policy Research Institute of Human Development, Child and Youth Health Institute of Infection and Immunity Institute of Neurosciences, Mental Health and Addiction Institute of Nutrition, Metabolism and Diabetes CIHR Knowledge Translation Branch Fonds de recherché en santé du Québec (FRSQ) Michael Smith Foundation for Health Research | ||
| Competition: May 2001 | ||
| IG Lead (or Co-Lead): COTE, Graham Queen's University |
Queen's University proteomics and protein function discovery training program | $1,478,710 over six years |
| HOURY,Walid University of Toronto |
Training program in protein folding: Principles and diseases | $1,800,000 over six years |
| JONES, Steven B.C. Cancer Research Centre |
Bioinformatics training for health research | $1,800,000 over six years |
| MAI, Sabine University of Manitoba |
Innovative technologies in multidisciplinary health research training | $1,800,000 over six years |
| MEYN, Stephen University of Toronto |
Collaborative graduate program in molecular medicine | $1.800.000 over six years |
| REINTHMEIER, Reinhart University of Toronto |
Training program in structural biology of membrane proteins linked to disease | $1,800,000 over six years |
| THOMAS, David McGill University |
CIHR strategic training program in chemical biology | $1,770,000 over six years |
| IG Sponsored: CROSS, James University of Calgary |
Training program in genetics, child development and health | $1,469,160 over six years |
| DOWNIE, Jocelyn Dalhousie University |
Training program in health law and policy | $1,575,000 over six years |
| FENSTER, Aaron John P. Robarts Research Institutes |
Vascular and cerebrovascular transdisciplinary training program (vcTTP): Integrated training in genetics, biology, mathematics, physics and engineering towards an understanding and prevention of vascular and cerebrovascular disease | $1,075,000 over six years |
| LABRIE, Fernand Université Laval |
Functional genomics and endocrine diseases | $1,680,000 over six years |
| LIU, Peter University of Toronto |
A training program in cardiovascular research: Molecules to populations, heart failure to prevention | $1.410.000 over six years |
| LYE, Stephen Mount Sinai Hospital |
The Samuel Lunenfeld Research Institute training program: Applying genomics to human health | $1.800.000 over six years |
| MCDONALD, Michael University of British Columbia |
Training program in ethics of health research | $1.599.782 over six years |
| ROSENBLUM, Norman Hospital for Sick Children |
Canadian child and youth health research clinician-scientist development program (CCYHR-CSDP) | $1,800,000 over six years |
| Drs.Walter and Jessie Boyd & Charles Scriver MD/PhD Studentship Award in partnership with the Canadian Gene Cure Foundation and the Canadian Genetic Diseases Network | ||||
| Summary | Competition Deadline | Applications Received (#) | Applications Approved (#) | Success Rate (%) |
| This award provides support for MD/PhD students with a research focus in the areas of genetics | July 2002 | 6 | 6 | 100 |
| Awardee(s): | ||||
| CARLSON, Christopher University of Alberta |
Characterization of Cox15p in heme metabolism and it's role in COX deficiencies | $123,000 over six years | ||
| DOLGETTA, Speranza University of Calgary |
Germ line engineering-Ethical aspects and public policy | $123,000 over six years | ||
| HYRCZA, Martin University of Toronto |
A functional genomics approach to elucidate the molecular mechanisms of T cell dysfunction in HIV-/AIDS | $123,000 over six years | ||
| LEVESQUE, Sébastien Université Laval |
Identification des gènes de susceptibilité à la préeclampsie | $123,000 over six years | ||
| MAYNES, Jason University of Alberta |
Identification of potential drug targets in mycobacterium tuberculosis | $123,000 over six years | ||
| ST-PIERRE, Julie Université Laval |
Genetic study of intermediate phenotypes in type 2 diabetes mellitus and its cardiovascular-associated complications in the Saguenay-Lac-St. Jean population | $123,000 over six years | ||
Facilitating the Work of Principal Investigators
| Institute of Genetics Career Transition Awards | ||||
| Summary | Competition Deadline | Applications Received (#) | Applications Approved (#) | Success Rate (%) |
| These awards support career transition of faculty members who are planning to undertake rigorous training outside of their primary area of expertise in order to transition into an area of need identified by the IG community. | November 2001 October 2002 |
6 2 |
4 1 |
67 50 |
| Competition Deadline: November 2001 | ||||
| Awardee(s): | ||||
| FLIBOTTE, Stephane Simon Fraser University |
Bioinformatics and comparable genomics | $80,000 over one year | ||
| PEGNA, Joseph École Polytechnique de Montréal |
Exploratory training toward a capacity in biomedical nanotechnologies | $70,000 over one year | ||
| HOGG, David University of Toronto |
Bioinformatics and software engineering | $80,000 over one year | ||
| ROBERTSON,Ann University of Toronto |
The meaning and use of genetic risk as evidence: Policy and practice issues at the intersection of human genomics, public health and bioethic | $68,333 over one year | ||
| Competition Deadline: October 2002 | ||||
| Awardee(s): | ||||
| WILD, Gary McGill University |
The identification of inflammatory bowel disease alleles using haplotype analysis | $80,000 over one year | ||
| Celera Genome Database Grant in partnership with CIHR | ||||
| Summary | Competition Deadline | Applications Received (#) | Applications Approved (#) | Success Rate (%) |
| By subsidizing the database licensing fee, this program enables more researchers to access Celera's proprietary genomic database. | May 2002 | 21 | 15 | 71 |
| Competition: May 2002 | ||||
| Grantee(s): | ||||
| BARBER, Dwayne Ontario Cancer Institute |
Identification of novel genes involved in normal and leukemogenis hemapoiesis | $18,000 over three years | ||
| BULMAN, Dennis Ottawa Hospital Research Institute |
Celera genome database grant | $18,000 over three years | ||
| DER, Sandy University of Toronto |
Utility of Celera database in the analysis of microarray mRNA expression data ant the development of novel gene promoter/CpG island DNA microarrays | $18,000 over three years | ||
| GROS, Philippe McGill University |
A genetic approach to understand host defences against infections | $18,000 over three years | ||
| HAYDEN, Michael University of Manitoba |
Celera genome database | $18,000 over three years | ||
| HICKS, Geoffrey University of Manitoba |
Bioinformatic analysis to identify defined embryonic stem cell mutations in genetic determinants of human disease and cancer | $18,000 over three years | ||
| MAGER, Dixie University of British Columbia |
Use of Celera database to facilitate mammalian genomic studies | $18,000 over three years | ||
| RANCOURT, Derrick University of Calgary |
Mitochondrial genetics | $18,000 over three years | ||
| SCHRADER, John University of British Columbia |
Celera genome database | $18,000 over three years | ||
| SHOUBRIDGE, Eric McGill University |
Mitochondrial genetics | $18,000 over three years | ||
| STEWART,Alexander Princess Margaret Hospital (Toronto) |
Celera genome database as a tool for studies in the biology of multiple myeloma and in the characterization of novel lipase genes | $18,000 over three years | ||
| TONIN, Patricia McGill University |
Celera genome database grant | $18,000 over three years | ||
| TREMBLAY, Michel McGill University |
Use of the CELERA database in the identification of new human cancer suppressor genes and in the functional analysis of the protein tyrosine phosphatase gene family | $18,000 over three years | ||
| WROGEMANN, Klaus University of Manitoba |
A genetic approach to understand host defences against infections | $18,000 over three years | ||
| Competition: November 2002 | ||||
| HEGELE, Robert John P. Robarts Research Institute |
Celera genome database initiative | $18,000 over three years | ||
| SIMINOVITCH, Katherine University Health Network (Toronto) |
Identification of genes underlying immunological diseases | $18,000 over three years | ||
| Short-Term Research Visits | ||||
| Summary | Competition Deadline | Applications Received (#) | Applications Approved (#) | Success Rate (%) |
| These grants facilitate cross-disciplinary training by giving biomedical and health researchers financial support for shortterm visits (three months or less) to research centres within Canada and abroad. | February 2002 | 12 | 9 | 75 |
| Competition: February 2002 | ||||
| Grantee(s): | ||||
| BARR, Cathy University Health Network |
Quantitative trait analysis of cognitive and behavioural phenotypes in clinical and population based samples | $10,000 over three months | ||
| BROCK, Hugh University of British Columbia |
Short-term exchange to learn mammalian tissue-culture and chromatin analysis techniques | $10,000 over three months | ||
| GIACOMINI, Mita McMaster University |
Incorporating ethical analysis of values into genetic services coverage policies | $10,000 over three months | ||
| LANDRY, Josette-Renée Terry Fox Laboratory |
Canadian bioinformatics workshop | $10,000 over three months | ||
| MAYNES, Jason University of Alberta |
Deriving constraints from low resolution X-ray data for the prediction of protein structures from myobacterium tuberculosis | $ 7,860 over three months | ||
| RAJCAN-SEPAROVIC, Evica B.C.'s Children's Hospital |
High resolution whole genome analysis of recurrent spontaneous abortions | $ 4,540 over three months | ||
| SHAW, Gary University of Western Ontario |
Folding and misfolding of disease-related proteins | $ 7,160 over three months | ||
| VACHER, Jean Institut de recherches cliniques de Montréal |
Molecular signalling pathway in pheomelanogenesis | $ 6,600 over three months | ||
| WEVRICK, Rachel University of Alberta |
Investigation of the zebrafish homologue of necdin, a candidate gene for Prader-Willi syndrome | $ 8,610 over three months | ||
| WILHELM, Brian University of British Columbia |
Canadian bioinformatics workshop | $ 2,100 over three months | ||
| One-Year Bridging Operating Grants | ||||
| Competition: March 2002 | ||||
| Grantee(s): | ||||
| DANSKA, Jayne Hospital for Sick Children |
Control of Type1 Diabetes pathogenesis by Idd4 and Idd11 | $178,662 over one year | ||
| EVANS, Jane University of Manitoba |
Numerical, clinical and epidemiological approaches to complex patterns of human malformations | $72,610 over one year | ||
| HUGHES,Timothy University of Toronto |
A proactive bioinformatics system for genome-scale hypothesis testing | $95,760 over one year | ||
| JURILOFF, Diana University of British Columbia |
Genetic and developmental studies of a mouse model of genetically multifactorial neural tube defects | $117,009 over one year | ||
| RAHMAN, Proton Memorial University of Newfoundland |
Disease related genes in psoriatic arthritis | $130,464 over one year | ||
| ROBERT, Jason Dalhousie University |
Conceptual and ethical issues at the intersection of genomics, developmental biology, ecology, and health | $17,910 over one year | ||
| ROGER,Andrew Dalhousie University |
The origin and early evolution of gene families and organelles in eukaryotes | $102,759 over one year | ||
| ROUSSEAU, François Université Laval |
Validation of genetic markers of preeclampsia | $88,884 over one year | ||
| ROUSSEAU, François Université Laval |
Validation of genetic markers of the risk of sporadic breast cancer using a large matched case-control study | $168,493 over one year | ||
| TIELEMAN, Dirk University of Calgary |
Theoretical approaches to membrane protein structure: Molecular simulation and computer modeling of helical membrane proteins and peptides | $38,000 over one year | ||
| Competition: November 2001 | ||||
| Grantee(s): | ||||
| DEGAARD, Kurt McGill University |
Molecular mechanisms of transmembrane proteins in the exocytic and endocytic pathways | $41,500 over one year | ||
| GAGNON, Cynthia Hôpital de Jonquière |
Functional and social consequences of mytonic dystrophy: Impact of personal and environment factors on social participation | $41,500 over one year | ||
| GARENC, Christophe Université de Lausanne |
Role of PPARs in lipase gene expression in adipocytes, monocytes and macrophages: Physiopathological and therapeutic pathways |
$41,500 over one year | ||
| LAGNEUX, Caroline McGill University |
The genetic dissection of stroke in the mouse model | $41,500 over one year | ||
| PETRYSHEN, Tracey Whitehead Institute of Biomedical Research |
Identification of sensorimotor gating genes by mouse DNA microarray gene expression studies | $46,500 over one year | ||
| ROY, Marie-France McGill University |
Study of the role of toll-like receptor 4 (tlr4) in the host inflammatory response of the mnd mouse mutant | $51,000 over one year | ||
| Knowledge Translation (KT) Strategies for Health Research | ||||
| Summary | Competition Deadline | Applications Received (#) | Applications Approved (#) | Success Rate (%) |
| General call: IG specific objectives of this program were to integrate an understanding of KT principles and practice into the training of health professionals. | October 2002 | 3 | 2 | 67 |
| Special Topic: Folic Acid and the Prevention of Birth Defects (In partnership with IAPH, IGH and INMD) | October 2002 | 1 | 1 | 100 |
| In partnership with the CIHR KT and Partnerships Portfolio and IHSPR | ||||
| Grantee(s): | ||||
| CARROLL, June Mount Sinai Hospital ALLANSON, Judith Children's Hospital of Eastern Ontario WILSON, Brenda University of Ottawa |
Evaluation of the impact of a multifaceted intervention to enhance the delivery of genetics services by family physicians | $282,964 over three years | ||
| WILSON, Brenda University of Ottawa |
The public and genetics: Understanding, expectations and priorities | $172,336 over two years | ||
| In partnership with the CIHR KT and Partnerships Portfolio and IGH | ||||
| Grantee(s): | ||||
| ST-CYR TRIBBLE, Denise Université de Sherbrooke |
Application des connaissances liées à l'acide folique dans la prévention des anomalies congénitales : évaluation de l'implantation d'un programme et des effets sur les pratiques professionnelles | $251,027 over three years | ||
Workshop and Symposium Applications: Reviewed and Funded
| Date and Location | Event | Financial Contribution ($) |
| April 25-26, 2003 (Kananaskis, Alberta) |
Crossing Over: Genomics in the Public Sphere Workshop | $10,000 |
| May 3, 2003 (Denver, Colorado) |
Genomic Approaches to the Immune System | $5,000 |
| May 8-9, 2003 (Montreal, Quebec) |
First Canadian State of the Art Conference on Von Willebrand Disease | $5,000 |
| May 13-14, 2003 (Winnipeg, Manitoba) |
Canadian Student Health Research Forum | $5,000 |
| May 23-27, 2003 (Vancouver, B.C.) |
3rd International Conferece - Canadian Proteomics Initiative (CPI) | $10,000 |
| May 27-28, 2003 (Montreal, Quebec) |
Pore-Forming Toxins and Maxi-Channels: From Structure to Therapeutics | $5,000 |
| June 6-7, 2003 (London, Ontario) |
Symposium on Molecular and Cellular Basis of Human Disease | $5,000 |
| June 16-17, 2003 (Toronto, Ontario) |
2nd International Congress on Schwachman-Diamond Syndrome | $5,000 |
| June 19, 2003 (Toronto, Ontario) |
International Symposium on Molecular Evolution | $5,000 |
| July 16-18, 2003 (Montreal, Quebec) |
Conférence internationale sur les facteurs de transcription GATA-Rôle des facteurs de transcription GATA dans l'homéostasie | $5,000 |
| August 7-12, 2003 (Vancouver, B.C.) |
David W. Smith 24th Annual Workshop on Malformations and Morphogenesis | $10,000 |
| September 7-11, 2003 (Mont-Tremblant, QC) |
6th Conference on Protein Expression in Animal Cells | $5,000 |
| September 29 - October 1, 2003 (Toronto, Ontario) |
Genome Policy Program: Preparing for the Genomics Revolution in Health | $2,500 |
| October 7 - November 18, 2003 (Vancouver, B.C.) |
Mini Med School Series entitled "Public Lectures in Genetics, Genomics and Health Research: Demystifying the Research, Engaging the Public, Capturing the Imagination" | $2,500 |
| October 8 - 11, 2003 (Montreal, QC) |
International Union of Biochemistry and Molecular Biology (IUBMB) 2003 | $26,500 |
| October 8 -11, 2003 (Montreal, QC) |
The Human Proteome Organization (HUPO) 2nd Annual World Congress | $5,000 |
| October 17-19, 2003 (Toronto, Ontario) |
Great Lakes G Protein-coupled Receptor (GPCR) Retreat | $5,000 |
| October 27-29, 2003 (Toronto, Ontario) |
Harmonizing Research and Privacy: Standards for a Collective Future Workshop | $10,000 |
| November 6-8, 2003 (Manoir du lac delage, Quebec) |
Congrés Institut national de la recherche scientifique (INRS) - Institute Armand-Frappier 2003 | $2,500 |
| January 23-24, 2004 (Vancouver, B.C.) |
Nursing in the Genomic Era: A Canadian Planning Forum | $2,500 |
| February 28 - March 4, 2004 (Banff, Alberta) |
4th International Conference on Unstable Microsatellites and Human Diseases | $15,000 |
| Total Contribution in Fiscal Year 2003-2004 | $140,000 |
