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Institute of Genetics
Canadian Institutes of Health Research
123 Edward Street, Suite 1211
Toronto, ON M5G 1E2
http://www.cihr-irsc.gc.ca/
© Her Majesty the Queen in Right of Canada (2003)
Cat. No.: MR1-21/2003E-PDF
ISBN 0-662-35913-5
Message from the Scientific Director
Excellent Researchers and a Robust Research Environment
Translation and use of Knowledge
It has been an honor to work with the Canadian community of researchers aligned with the Institute of Genetics (IG), and with our colleagues at CIHR and at other national, provincial and local institutions, during the second year of life of the IG. In particular, I would like to thank my fellow Scientific Directors at CIHR for their intelligence and collegiality in helping to build the IG and CIHR as a whole.
A major highlight of the year was a Strategic Planning Retreat held in September 2002 in Aylmer, Quebec, to consult with more than 60 leaders of the IG research community, as well as international research leaders, on the Draft Strategic Plan of the Institute. The principal outcome of the Retreat was a strong affirmation that, overall, the IG was "getting it right", and that our Research Priorities had been wisely chosen. However, the Retreat led to the identification of one new Research Priority Theme, entitled "From Genes to Genomic Medicine". Although the precise focus of the Request for Applications that arise from this Theme will be defined over the next year, the idea behind this initiative is that the IG must foster research in Canada that will take full advantage of the remarkable knowledge of the human genome, by applying that knowledge, as fully as possible, to some of the major problems in clinical medicine. The formulation of this Theme brings to six the number of Research Priority Themes of the IG, and defines the overall direction of the IG for at least the next 5 years.
A second highlight was our sponsorship of the First Annual New Principal Investigators (PIs) Meeting. More than 100 new PIs from across the country, working in genetics, biochemistry, developmental biology and cell biology, met with their peers, largely for the first time, and with leading scientific mentors. This meeting allowed the next generation of Canadian health researchers (from all four pillars of CIHR) to begin to create new networks and collaborations, and to obtain council on how to succeed as an independent researcher. The meeting was judged to be a great success by the new PIs and will therefore become a permanent part of the IG repertoire; it will be held annually, often in collaboration with fellow CIHR Institutes. I would like to thank the P & P Committee that organized this event, led so effectively by Dr. Geoff Hicks of the University of Manitoba, for their excellent work.
The Requests for Applications (RFAs) from the IG in 2002-2003 includes one set of RFAs of which the IG is particularly proud, and that will become stable components of the CIHR RFA landscape. These RFAs were designed to address research issues that remain relatively constant, and that are not focussed on any particular area of research. Particularly exciting RFAs of this type were "Invention: Tools, Techniques and Devices for Research and Medicine", which was designed to foster invention research, and the "New Discoveries: Seed Grants" RFA, which invited applications on high-risk:high-benefit projects. The response of the research community and the review panels to both of these RFAs was excellent. It is notable that the applications submitted, because of their focus, would generally not have been well suited to the mandates of any of the current review panels in the Open Grants Competition, indicating that these RFAs have an important role to play in the Canadian health research funding landscape.
One of the great pleasures associated with being the Scientific Director of the IG is the opportunity to work with the country's leading researchers to build the Institute. Under the excellent leadership of the Chair, Dr. Joel Weiner (University of Alberta) and Vice-Chair, Dr. François Rousseau (Université Laval), the IAB continues to show great leadership and judgement in advising me on the directions the Institute should take. I owe an equally great debt to the more than 100 researchers who, as Chairs or members of our 11 Priority and Planning Committees, advise the Institute on the issues it should address in the specific area of research related to each Committee.
Finally, the Institute of Genetics continues to be blessed with remarkably capable and congenial staff who have made the job of Scientific Director a true pleasure. In particular, I would like to thank the Assistant Directors, Dr. Milka Popov and Stephanie Robertson, the Executive Assistant and Project Manager, Jennifer Jennings, and the Administrative Assistant Esther Berzunza for their wise counsel, enthusiastic support and endless capacity for blending hard work with humour, during the past year.
Sincerely,
Roderick R. McInnes, M.D., Ph.D., FRSC
Scientific Director
Institute of Genetics
Canadian Institutes of Health Research
Established in December 2000, the Institute of Genetics (IG) is one of 13 virtual Institutes of the Canadian Institutes of Health Research (CIHR). The IG is based at the Hospital for Sick Children in Toronto, the home institution of the Scientific Director, Dr. Roderick R. McInnes.
The IG's Institute Advisory Board (IAB) consists of 17 individuals with exceptional qualifications and demonstrated leadership, from Canada and abroad, under the guidance of the Chair, Dr. Joel Weiner, and the Vice-Chair, Dr. François Rousseau (see Appendix 1). IAB members represent a variety of disciplines, sectors, geographic regions and pillars of health research. The IAB provides essential expertise and advice regarding determination of IG priorities, implementation of IG initiatives, and communication with stakeholders and the broader community.
The IG will support excellent research on the genetic and biochemical basis of health and disease, including the interaction of genes with the physical and social environments, to facilitate the translation of research findings into health policy and practice, and to examine the ethical, legal and social implications of genetic discoveries (see Figure 1).
Draft Strategic Plan. Building on national consultations and workshops held with scientists, academics, government, voluntary health organizations and other stakeholders over the previous 18 months, the IG draft Strategic Plan "Strategic Directions: Consulting with our Community" was developed and released in September 2002. The report outlines six research priority themes and six strategic goals and a number of enabling strategies to assist the IG in achieving its mandate and vision.
2002 Strategic Planning Retreat. To obtain commentary on the draft Strategic Plan from the IG community, the IG held a retreat. Over 60 leading researchers, academics and key players in the genetics and biochemistry research community were invited to consider the proposed strategic directions and research priority themes presented in the draft plan. This consultative activity led to the further refinement of the IG's strategic goals and research priority themes. After finalizing the Strategic Plan, the IG will continue to consult with researchers and stakeholders, adjusting its strategic directions to changing research needs.
Genetic and Environmental Interactions in Health and Disease
Integrating the Physical and Applied Sciences into Biomedical Research
Proteomics and Bioinformatics
Health Services for Genetic Disease
From Genes to Genomic Medicine (including Clinical Genetics Research)
Genetics and Ethical, Legal and Social Issues
Funding of two Training Program Grants (in partnership) Funding of two Short-Term Research Visits Funding of six "Facing our Future: Human Genetics, Ethics, Law and Society" Grants Funding of one Career Transition Award
The Priority and Planning Committees of the IG. The activities of the Institute, for each Research Priority Theme, are directed by a Priority and Planning (P&P) Committee (see Appendix 2). The P&P Committees are led, or co-led, by a distinguished Canadian researcher(s) with expertise and a strong commitment to advancing research in a specific area (see Figure 2). It is the responsibility of each P&P Committee to:
Priority & Planning Committees and Working Group of the Institute of Genetics
Requests for Applications (RFAs) Launched by the IG. During this reporting period, significant work was carried out by the P&P committees of the IG, including the issuing of 15 Requests for Applications.
| Encouraging Innovation | Invention: Tools, Techniques and Devices for Research and Medicine* | New Discoveries: Seed Grants* | |||
| Fostering Research in Areas of Emerging Importance | Facing our Future: Human Genetics, Ethics, Law and Society* | Novel Population Genetics and Genetic Epidemiological Methods for Studies for Complex Genetic Diseases | Staying Ahead of the Wave: Genetics, Health Services and Health Policy | New Emerging Teams (NETs): Integration of Mathematics, Statistics and Biophysics into Biomedical Research | New Emerging Teams (NETs): Integration of Fundamental Bioengineering into Biomedical Research |
| Research Capacity Building | Training Program Grants | Interface Fellowship in Chemistry Senior Research Interface Fellowship in Chemistry |
Interdisciplinary Capacity Enhancement Research Teams* | Clinical Investigatorship Award* | Drs. Walter and Jessie Boyd & Charles Scriver MD/PhD Studentships* |
| Facilitating the Work of Principal Investigators | Short-Term Research Visits* | Career Transition Awards | Celera Genome Database Grant* | ||
| Knowledge Transition | Strategies for Knowledge Translation* | ||||
| * RFA Competition results are presented in Appendix 3 | |||||
| Note: For RFA competition results announced in a previous reporting period, details of ongoing strategic funding commitments are listed in Appendix 4. | |||||
In partnership with the Institute of Musculoskeletal Health and Arthritis (IMHA), the IG has developed two unique programs that focus on invention, or on high-risk/high-benefit projects.
The Invention: Tools, Techniques and Devices for Research and Medicine RFA. This program promotes invention development and application, rather than discovery research or hypothesis-driven research. Of the eight IG-related applications received to the October 2002 competition deadline, four were approved for funding. This highly successful program is scheduled to be relaunched in June 2003, and will be a constant feature of the IG research funding landscape.
The New Discoveries: Seed Grants program RFA. This program supports novel, high risk research ideas of excellent quality and of great potential. Of the eight IG-related applications received by the October 2002 competition deadline, four were approved for funding. This program is also scheduled to be relaunched in June 2003.
The Facing Our Future: Human Genetics, Ethics, Law and Society RFA. In partnership with the Institute of Population and Public Health (IPPH) and the Institute of Aging (IA ), the IG launched this program to provide developmental one-year funding for projects focused on the critical analysis of current ethical, legal and social practices involving population-based genetic research as well as implications for future studies in Canada. Of the 11 applications received by the November 2002 competition deadline, six were approved for funding. All Facing our Future RFA grantees (or trainees) presented their proposal at the Genome Canada GE3LS Winter Symposium; and will present their results at the 2004 meeting.
The Novel Population Genetic and Genetic Epidemiological Methods for Studies of Complex Genetic Diseases RFA. The IG launched this program, in partnership with the IPPH, to foster research and build research capacity in the rapidly developing areas of population genetics and genetic epidemiology of complex diseases. This initiative will help individuals or teams to develop the new theories, strategies and methodologies needed to facilitate more conclusive, high-quality etiological studies of complex diseases, including genetic and environmental co-determinants over the life course. Results of this competition will be available in the summer of 2003.
Benefit-Sharing: Commercial Sponsors' Perspectives. The World Health Organization and the Human Genome Organization have suggested that commercial sponsors of human genetic research should be required to share a portion of the benefits that accrue from that research directly with other stakeholders. But who are the other stakeholders and what kinds of benefits should they receive? Dr. Daryl Pullman and Dr. Andrew Latus (Faculty of Medicine, Memorial University of Newfoundland) - Facing our Future: Human Genetics, Ethics, Law and Society Co-Principal Investigators - are investigating how corporate sponsors of human genetic research conducted in Canada view the subject of benefit-sharing.
The Staying Ahead of the Wave: Genetics, Health Services and Health Policy RFA. In partnership with IHSPR, this program provides development funds in support of projects that are likely to lead to the development of research proposals or programs of inquiry to "ensure that the inevitable growth in genetic health services is in accordance with scientific evidence and in a way that enables us to reap its full benefit" (Health Services Utilization and Research Commission - HSURC, 2001). Results of this competition will be available in the summer of 2003.
The "Integration of Mathematics, Statistics and Biophysics into Biomedical Research" and the "Integration of Fundamental Bioengineering into Biomedical Research" New Emerging Team (NETs) RFAs. This novel CIHR grants program has garnered much praise and enthusiasm from the research community. This program was developed: to build capacity in new and developing areas of research; to build new research teams; and to give researchers a building block for applying for research funding in future years. The IG joined the summer 2002 relaunch of the NET program in the following research foci: Integration of Mathematics, Statistics and Biophysics into Biomedical Research and Integration of Fundamental Bioengineering into Biomedical Research (in partnership with the Institute of Cancer Research). Results of this competition will be available in the spring of 2003.
The Strategic Health Research Training Program Initiative. Launched in May 2001, the CIHR Strategic Health Research Training Program aims to build the capacity of the Canadian health research community by training and supporting young talent. This program was the first major CIHR strategic initiative to involve all 13 Institutes and their partners. In May 2002, 51 new training programs were funded for a total investment of $85 million over six years. Of these, 15 training programs were co-funded by the IG and its partners (see Appendix 4). The programs deliver unique training, creative curriculum, and often involve faculty from diverse disciplines and backgrounds. For fiscal year 2002-03, commitments towards these training programs represent 28% of the IG's strategic initiative funding. In its second call for applications, the IG focused on developing research capacity in bioinformatics, clinical genetics research and population genetics and genetic epidemiology of complex diseases. Results of this competition will be available in the spring of 2003. IG-Bridging Fellowship Awards. From the November 2001 CIHR Fellowships competition, the IG supported six IG-related awards - that were highly rated but fell below the CIHR cut-off for funding - for a term of one year. The Short-Term Research Visit RFA. This RFA facilitates cross-disciplinary training by giving biomedical and health researchers financial support for short-term research visits (three months or less) to research centres within Canada and abroad. During the reporting period, the IG approved 30 grants over three competition deadlines. The Career Transition Awards RFA. This program is designed to support career transition of faculty members who are planning to undertake rigorous training in identified areas of need outside of their primary research training and expertise. These awards support up to 100% release time from teaching, clinical and administrative responsibilities. The IG is funding four awards from the November 1, 2001 competition. Of the two applications received by the November 2002 deadline, one was approved for funding. This program is scheduled to be relaunched in June 2003. The Celera Genome Database Grant RFA. Consistent with the CIHR's aim of strengthening health research and the health care system in the genomics era, CIHR and the IG have launched this RFA to enable more Canadian health researchers to have access to the Celera Discovery System - Celera's proprietary genomic databases - by subsidizing the licensing fee. Over two competitions, 25 applications were received, of which 17 were approved for funding. The First Annual New Principal Investigators Meeting. In November 2002, approximately 100 new principal investigators, working in the area of biochemistry, cellular biology, molecular biology and bioinformatics, came from across the country to meet and engage with their peers and with leading scientists at the inaugural New Principal Investigators Meeting. The goals of this meeting were to create a strong network in Canada's upcoming generation of biomedical researchers, to foster new collaborations and interdisciplinary adventures, and to provide strong guidance and mentorship. The IG will host this event annually, at least for the next five years, and planning is already underway for the November 2003 meeting in partnership with the Institute of Neurosciences, Mental Health and Addiction (INMHA). The Workshop Support RFA. During this reporting period, the IG committed approximately $175,000 towards funding 19 workshops (see Appendix 5). IG-Bridging Operating Grants. From the March 2002 CIHR Operating Grants competition, the IG provided one-year funding in support of 10 IG-related operating grants that were highly rated, but fell below the CIHR cut-off for funding. Of these ten applications, four operating grant proposals were resubmitted and approved in the September 2002 competition. IG & CIHR Multi-User and Equipment Grants. From the October 2002 CIHR Multi-User and Equipment Grants competition, the IG supported eight IG-related grants by providing the first year of funding. For subsequent years, funding will be provided by CIHR. Top-Up Funding for IHRT Grants. The IG provided approximately $187,000 towards three Interdisciplinary Health Research Team (IHRT) grants to align the level of funding for each of these grants with the budgetary recommendations made by the peer review committee. The Canadian Lifelong Health Initiative (CLHI). This initiative will place Canada at the forefront of modern health research by creating a common research platform that will give Canadian scientists a unique advantage when carrying out decades-long population studies. CLHI will focus on the genetic, social and other environmental influences that determine health throughout life. This initiative has two components - the Multigenerational Canadian Birth Cohort Study (MCBC) and the Canadian Longitudinal Study on Aging (CLSA). Efforts are currently underway to explore the potential integration of both studies into a multigenerational cohort "platform". The aim of the CLHI is to launch a multi-year program of research in Canada to identify the multi-factorial causes of the most common diseases of post-industrial society, with a long-term goal of devising prevention strategies. This initiative is championed by the Institute of Aging (IA), the Institute of Genetics (IG), the Institute of Human Development, Child and Youth Health (IHDCYH) and the Institute of Population and Public Health (IPPH). The IG committed funding this year to two programs in support of the MCBC study: the Novel Population Genetic and Genetic Epidemiological Methods for Studies of Complex Genetic Diseases RFA; and the Population-based Health and Health Service Data in Canada RFP. The Regenerative Medicine and Nanomedicine Initiative. In partnership with the INMHA, the IG is co-leading the CIHR Regenerative Medicine and Nanomedicine Initiative. This initiative will support the development of nanotechnology relevant to the basic understanding, diagnosis, and treatment of disease, focusing on the integration and application of the physical, engineering, and chemical sciences with the biosciences. Chemistry Focus Forum & Fellowship RFA. In July 2002, the IG sponsored the Chemistry Focus Forum, in partnership with the Institute of Cancer Research (ICR), the Institute of Circulatory and Respiratory Health (ICRH) and the Institute of Infection and Immunity (III). At this forum - which addressed emerging research opportunities at the interface of chemical and biomedical research - discussion quickly made clear the need for postdoctoral fellowship funding to foster research and develop research capacity at the interface of these two disciplines. In response, the IG developed two funding programs - Interface Fellowship in Chemistry and Senior Research Interface Fellowship in Chemistry - designed specifically to provide this opportunity. Results of these competitions will be available in the summer of 2003.
Excellent Researchers and a Robust Research Environment Research Capacity Building
Facilitating the Work of Principal Investigators
Focus on Genetic and Environmental Interactions in Health and Disease
Focus on Integrating the Physical and Applied Sciences into Biomedical Research
Left to right: Lori Sheremeta, Ian Graham, Denise Avard, Heather Howley, Brenda Wilson, Jeremy Grimshaw, Richard Gold, Doug Coyle, Jacques Simard. Members of the IG & IHSPR Interdisciplinary Capacity Enhancement (ICE) Team entitled "Translating genetics discoveries into appropriate health policy and services: Enhancing research capacity and developing an interdisciplinary approach".
Focus on Health Services Research for Genetic Diseases
The Interdisciplinary Capacity Enhancement (ICE) Research Teams. Over the next five years, the IG and the IHSPR have committed over $2 million to fund two ICE Research Team Grants in the area of Genetics and Health Services. These grants provide support for new or existing groups that have demonstrated commitment to engendering a trans-disciplinary research culture; and will attract, engage and mentor junior researchers or established researchers who have not worked extensively in this research domain.
An Environmental Scan of Health Services for Genetic Diseases. In September 2002, the joint IG and the IHSPR Health Services for Genetic Diseases P&P Committee made available a commissioned environmental scan entitled "Research into Genetic Testing Services and Related Matters". This environmental scan provides background information in the form of an overview of policy documents and reports and captures relevant policy and research activity regarding the social, legal, ethical and health service policy implications surrounding the use of genetic technologies in health care (mainly genetic testing).
The Drs. Walter and Jessie Boyd & Charles Scriver MD/PhD Studentship Award RFA. This program - offered in partnership by the IG, the Canadian Gene Cure Foundation (CGCF) and the Canadian Genetic Diseases Network (CGDN) - provides support for students enrolled in MD/PhD programs with a research focus in one of the following areas: genetics and genetic-related diseases (including medical genetics, bioinformatics, and bioethics of medical genetics); population genetics; translational genetics; and fundamental biochemical research - in healthy and disease states.
The IG and its partners have committed $1.23 million over the next six years to ten MD/PhD Studentship awards (as of fiscal year 2002-03). All six applications received in the July 2002 competition were approved for funding. This program was recently relauched by the IG, CGCF and CGDN.
"The long-term impact of the Scriver MD/PhD Studentships will be an increase in the number of physicians committed to genetics research" -
Dr. Ron Wosnow, CEO, Canadian Genetic Diseases Network
The Clinical Investigatorship Award RFA. This program helps clinical geneticists become successful clinical genetics investigators by providing two years of protected research time. This award is targeted at clinical geneticists, clinical cytogeneticists, clinical biochemical geneticists, clinical molecular geneticists, genetic counselors, and medical geneticists holding a PhD. Of the four applications received by the July 2002 deadline, two were approved for funding.
A Canadian Molecular Cytogenetics Platform. In November 2002, 30 researchers in clinical genetics, cytogenetics, molecular genetics, and genomics from throughout Canada met in Montreal to discuss the creation of a Canadian Molecular Cytogenetics Platform. Sponsored by the IG, the goal of this meeting was to establish a consortium to plan a strategy for implementing the next generation of molecular cytogenetic research projects and enabling technology in Canada. A component of this project, the supporting bioinformatics platform, will be developed in collaboration with the University Joseph Fourier - Medical School of Grenoble, France.
The CIHR Clinical Research Initiative. The IG is a contributor to the CIHR Clinical Research Initiative - led by the Institute of Circulatory and Respiratory Health (ICRH) - which addresses issues facing clinical research and clinician scientists in Canada.
During the reporting period, as evidenced throughout this report, the IG collaborated with other Institutes, Voluntary Health Organizations and government to build on the IG's strengths and capitalize on Canada's health research investment.
During this reporting period, the IG had a substantial presence at major international meetings such as the American Society of Human Genetics (October 2002) and the Human Genome Organisation (March 2003), including the hosting of an information booth at each meeting.
Voluntary Health Organizations. The mandate of the IG's VHO Working Group is to encourage the engagement and collaboration of the VHO sector with the IG and to model ways of working together that could be replicated by others in CIHR. Towards that end, the IG is strongly involved with the CIHR-Health Charities of Canada Working Group, which addresses issues identified in the 2002 CIHR and Voluntary Health Sector Report, such as advocacy, peer review, knowledge translation, partnerships, communications and branding. In January 2003, the IG sponsored and participated in "Orchestrating Partnerships", a workshop developed to enhance partnerships in the voluntary health sector.
Government. Formal and active linkages have been established between the IG & IHSPR Health Services for Genetic Diseases P&P Committee and the Federal/Provincial/Territorial Coordinating Committee on Genetics and Health, including the signing of an MOU in August 2002. This F/P/T Coordinating Committee has wide representation from the provinces, territories and federal government, and is actively working on a range of policy issues pertaining to the current and future role of genomic medicine in health care. In September 2002, a joint steering committee was created to provide a forum for discussion of shared issues, including delivery of testing and services, privacy, technology assessment and discrimination, health human resources and the use of genetic information.
International. The IG and CGDN International Collaborations in Human Genetics P&P Committee has a mandate to identify areas of research that are synergistic between two countries and will lead to meaningful research collaborations. One example of the P&P Committee's efforts was the sponsoring and hosting of the inaugural "New Frontiers: Italian/Canadian Population Genetics and Bioinformatic Collaborations" meeting. In partnership with the Italian Embassy and CGDN, over 30 leading Canadian and Italian researchers in the fields of population genetics and bioinformatics attended this meeting in Montreal (December 2002). In addition to the Italian Trade Commission, there was representation from Industry (e.g., Xenon Genetics Inc. and Newfound Genomics). Three hours of spontaneous discussion took place after the meeting had officially adjourned, and an Italian researcher offered to host a reciprocal meeting in Italy during the fall of 2003.
The IG also reached an agreement with the Canada-France Research Foundation to cover expenses of French and Canadian researchers working on collaborative research projects. Since the signing of the agreement in early 2003, the IG has already supported one project.
The Strategies for Knowledge Translation RFA. Led by the CIHR Knowledge Translation and Partnerships Portfolio - in partnership with all 13 Institutes - the IG participated in the launching of this RFA to:
Over the next three years, the IG, the Institute of Health Services and Policy Research (IHSPR), and the CIHR KT and Partnerships Portfolio have committed to fund two grants in support of genetic knowledge translation studies. In addition, the IG funded a knowledge translation research grant on the use of folic acid supplementation, in partnership with the Institute of Gender and Health and the CIHR KT and Partnerships Portfolio.
From Genes to Genomic Medicine Research Priority Theme. The primary focus of this newly established IG research priority theme is to fund research leading to the application of genetics discoveries. This research priority theme has emerged from the latest strategic consultation meeting and will be further developed with input from a broad community of researchers and stakeholders.
Facilitating Linkages with Policy Makers. The Federal/Provincial/Territorial Coordinating Committee on Genetics and Health (F/P/T), the IHSPR and the IG are collaborating to facilitate linkages between policy makers and researchers who submitted applications to the Staying Ahead of the Wave: Genetics, Health Services and Health Policy RFA.
Education and Public Engagement
The "Be a Gene Researcher for a Week" Program. The CGDN, in partnership with the IG, launched a nation-wide training program in genetics for high school students in March 2003. "Be a Gene Researcher for a Week, the Ramon Hnatyshyn Youth in Science Initiative", gave high school students the opportunity to spend their spring break week in CGDN and IG research labs. The objective of this program was two-fold: to give young Canadians the chance to learn more about science in a dynamic environment; and to inspire young Canadians to pursue careers in science and genetics. Planning is underway to relaunch this program for spring break 2004.
The Geee! In Genome. This travelling museum exhibit is an innovative, multi-dimensional public education project developed by the Canadian Museum of Nature (CMN) in partnership with Genome Canada and CIHR. Opening in Ottawa (April 2003), the program will present a broad spectrum of information about genomics, serve as a tribute to the late Dr. Michael Smith, and showcase Canadian researchers. Throughout the development of this project, the IG and CIHR have played an active role on the concept design team.
The accomplishments of the IG during this reporting period towards building a national health research agenda in genetics and basic biochemistry are a direct reflection of the dedication, commitment and collaborative involvement of the Scientific Director, the IAB, the P&P Committees and Working Group, and the
IG staff.
Institute Advisory Board members provide invaluable assistance and advice with the development and implementation of the IG's research priority-setting process. In addition to participating actively on P&P Committees, IAB, members meet at least twice a year to discuss the activities of the IG's research priorities.
The P&P Committees and VHO Working Group are integral to the IG's ability to carry out its mandate. The P&P Committee for each research priority theme gathers input from that research community regarding research priorities. Additional P&P Committees and the VHO Working Group enable IG development in other critical areas, such as international collaborations in human genetics, public engagement, knowledge exchange and new principal investigators. These P&P Committees and the VHO Working Group present recommendations to the IAB, for discussion and funding consideration. Through this process, over 100 leading researchers and committed stakeholders regularly inform and advance the IG's genetic and basic biochemical health research agenda.
Operationally, the IG is supported by teams based at the Hospital for Sick Children in Toronto and the CIHR Secretariat in Ottawa.
Scientific Director
Roderick R. McInnes, MD, PhD
Tel: (416) 813-7671
Fax: (416) 813-7673
rodig@sickkids.ca
Assistant Director
Milka Popov, PhD
Tel: (416) 813-7670
Fax: (416) 813-7673
mpopov@sickkids.ca
Executive Assistant and Project Manager
Jennifer Jennings, BA
Tel: (416) 813-7400
Fax: (416) 813-7673
jennig@sickkids.ca
Administrative Assistant
Esther Berzunza
Tel: (416) 813-7671
Fax: (416) 813-7673
estherig@sickkids.ca
Student, Part-Time
Clayton Cheng
Tel: (416) 813-7672
Fax: (416) 813-7673
adminig@sickkids.ca
Institute Project Officer, Part-Time
Amanda Dodge
Tel: (613) 941-0997
Fax: (613) 941-1040
adodge@cihr-irsc.gc.ca
CIHR Insitute of Genetics
123 Edward Street, Suite 1211
Toronto, ON
M5G 1E2
CIHR Secretariat
410 Laurier Avenue, West
9th Floor
Postal Locator 4209A
Ottawa ON K1A 0W9
| Available Funds | $ 1,545,377.29 | |
| Expenses | ||
| Institute Development | ||
| Conference, symposia and workshops | $ 529,114 | |
| Institute Advisory Board | 69,644 | |
| Professional services | 83,492 | |
| Travel expenditures | 1,912 | |
| Other costs | 7,669 | $ 691,832 |
| Institute Operations | ||
| Salaries and benefits | $ 393,650 | |
| Office accomodations | 16,222 | |
| Telephone and communication services | 9,749 | |
| Supplies, material and other services | 15,621 | |
| Office furniture and fixtures | 270 | |
| Computer equipment and IT support | 15,509 | |
| Professional services | 11,286 | |
| Travel expenditures | 66,316 | |
| Other expenditures | 2,797 | $ 531,421 |
| Total Expenses | $ 1,223,253 | |
| Unspent Balance* | $ 322,125 | |
| *Note: The unspent balance as at March 31, 2003 is carried forward to the subsequent fiscal year | ||
| Contributions through Grants and Awards | ||||||
| Number | 2002-2003 | 2003-2004 | 2004-2005 | 2005 and beyond | Total | |
| Strategic Initiatives | ||||||
| Career Transition Awards | 5 | 203,333 | 185,000 | 388,333 | ||
| Celera Genome Database Grants | 10 | 120,528 | 36,000 | 156,528 | ||
| Clinical Investigatorship | 2 | 120,000 | 240,000 | 120,000 | 480,000 | |
| Drs. Walter and Jessie Boyd & Charles Scriver MD/PhD Studentships |
6 | 33,168 | 61,500 | 61,500 | 150,750 | 306,917 |
| Facing our Future: Human Genetics, Ethics, Law and Society |
6 | 16,998 | 124,715 | 141,713 | ||
| Interdisciplinary Capacity Enhancement Research Teams |
2 | 55,298 | 194,618 | 199,753 | 549,665 | 999,334 |
| Invention: Tools, Techniques and Devices for Research and Medicine |
4 | 34,444 | 331,045 | 331,045 | 303,459 | 999,993 |
| Knowledge Translation Strategy | 3 | 27,000 | 70,740 | 63,926 | 8,334 | 170,000 |
| Multi-user Equipment Grants | 8 | 923,729 | ||||
| New Discoveries - Seed Grants | 4 | 3,229 | 207,376 | 204,147 | 414,752 | |
| One-year Bridging Fellowships | 4 | 80,625 | 99,875 | 180,500 | ||
| One-year Bridging Operating Grants | 10 | 601,163 | 484,000 | 1,085,163 | ||
| Short-Term Research Visits | 27 | 162,469 | 162,469 | |||
| Top-up Funding for IHRT Grants | 3 | 187,944 | 187,944 | |||
| Training Program Grants | 15 | 975,484 | 1,020,000 | 1,020,000 | 1,020,000 | 4,035,484 |
| 109 | $3,545,412 | $3,054,869 | $2,000,371 | $2,032,208 | $9,709,130 | |
| Note : Grants and awards in respect to these programs are approved for 1 to 6 years. Figures displayed represent CIHR financial commitments for these programs in 2002-03 and subsequent years. Availability of these funds in future years are subject to IG budget appropriations and IAB, decisions. For some initiatives, partners contributed additional funds to the funding of the grants and awards. CIHR Training Program Grants include 3 in-name only grants, therefore 3/14 do not represent a monetary contribution. IG support for IHRT, projects was supplement up to the full recommended funding amount, for one year, only. | ||||||
Dr. Joel Weiner (Chair)
University of Alberta
Dr. François Rousseau (Vice-Chair)
Université Laval
Dr. Béatrice Godard
Université de Montréal
Dr. Jane Green
Memorial University of Newfoundland
Dr. Michael Hayden
University of British Columbia
Dr. Philip Hieter
University of British Columbia
Dr. Tom Hudson
McGill University
Ms. Suzanne Lawson
Amyotrophic Lateral Sclerosis Society of Canada
Dr. James McGhee
University of Calgary
Dr. Robert Peterson
Health Products and Food Branch
Dr. Janet Rossant
University of Toronto
Dr. Michael Snyder
Yale University
Dr. Andrew Storer
National Research Council of Canada
Dr. Natalie Strynadka
University of British Columbia
Dr. Julien Veilleux
Ministère de la santé et des services sociaux
Ex officio members
Dr. Françoise Baylis
Dalhousie University
Dr. Philippe Gros
McGill University
Dr. Alexander MacKenzie
Genome Canada
Mr. Joseph Rotman
CIHR Governing Council
Bioinformatics
Dr. Peter Lewis, University of Toronto (Co-Chair)
Mr. Francis Ouellette, University of British Columbia (Co-Chair)
Dr. Fiona Brinkman, Simon Fraser University
Dr. William Crosby, University of Saskatchewan
Dr. Steven Jones, British Columbia Cancer Agency
Dr. Paul Kearney, University of Waterloo
Dr. François Major, Université de Montréal
Dr. Andrew Roger, Dalhousie University
Dr. Christoph Sensen, University of Calgary
Dr. Chris Upton, University of Victoria
Clinical Genetics Research
Dr. Jan Friedman, University of British Columbia (Chair)
Dr. Jane Evans, University of Manitoba
Dr. David Rosenblatt, McGill University
Dr. Jacques Simard, Université Laval
Dr. Rosanna Weksberg, Hospital for Sick Children
Developmental Genetics and Birth Defects
Dr. James McGhee, University of Calgary (Chair)
Dr. Jacques Drouin, Institut de recherches cliniques de Montréal (Vice-Chair)
Dr. Paul Lasko, McGill University
Dr. Howard Lipshitz, Hospital for Sick Children
Dr. Jacques Michaud, Hôpital Ste. Justine
Dr. Janet Rossant, Samuel Lunenfeld Research Institute
Genetic and Environmental Interactions in Health and Disease
Dr. Shelley Bull, Samuel Lunenfeld Research Institute (Co-Chair)
Dr. Kenneth Morgan, Montreal General Hospital (Co-Chair)
Dr. Robert Brunham, University of British Columbia
Dr. Gail Eyssen, University of Toronto
Dr. France Gagnon, University of Ottawa
Dr. Jinko Graham, Simon Fraser University
Dr. Jane Green, Memorial University of Newfoundland
Dr. Celia Greenwood, Hospital for Sick Children
Dr. Robert Hegele, University of Western Ontario
Dr. Claude Laberge, Université Laval
Dr. John McLaughlin, Samuel Lunenfeld Research Institute
Dr. Bruce Rannala, University of Alberta
Health Services for Genetic Disease (with IHSPR)
Dr. Judith E. Allanson, Children's Hospital of Eastern Ontario, (Co-Chair)
Dr. Eva Grunfeld, Ottawa Regional Cancer Centre, (Co-Chair)
Dr. Denise Avard, Université de Montréal
Dr. Mario Cappelli, Children's Hospital of Eastern Ontario
Dr. June Carroll, Mount Sinai Hospital
Dr. Tim Caulfield, University of Alberta
Dr. Raisa Deber, University of Toronto
Dr. Daniel Gaudet, Complexe Hospitalier de la Sagamie
Dr. Christine Kennedy, University of Calgary
Dr. François Rousseau, Université Laval
Dr. Brenda Wilson, University of Ottawa
Genetics and Ethical, Legal and Social Issues
Dr. Tim Caulfield, University of Alberta (Co-Chair)
Dr. Margaret Lock, McGill University (Co-Chair)
Dr. Laura Arbour, University of British Columbia
Dr. Françoise Baylis, Dalhousie University (ex officio)
Dr. Abdallah Daar, University of Toronto
Dr. Jane Evans, University of Manitoba
Dr. Béatrice Godard, Université de Montréal
Ms. Patricia Kosseim, CIHR Ethics Office (ex officio)
Dr. Trudo Lemmens, University of Toronto
Dr. Daryl Pulman, Memorial University of Newfoundland
Proteomics
Dr. Joel Weiner, University of Alberta (Chair)
Dr. Brenda Andrews, University of Toronto
Dr. John Bergeron, McGill University
Dr. Mirek Cygler, National Research Council Canada
Dr. Michel Desjardins, Université de Montréal
Dr. Mike Moran, MDS Proteomics
Dr. Natalie Strynadka, University of British Columbia
Dr. Hans Vogel, University of Calgary
Dr. David Wishart, University of Alberta
Integrating the Physical and Applied Sciences into Biomedical Research (in progress)
Dr. Philip Hieter, University of British Columbia (Co-Chair)
Dr. Christopher Yip, University of Toronto (Co-Chair)
B. Committees Supporting the IG Enabling Strategies
International Collaborations in Human Genetics, (with CGDN)
Dr. Stephen Scherer, Hospital for Sick Children (Chair)
Dr. Diane Cox, University of Alberta
Dr. Louise Desjardins, Canadian Genetic Diseases Network (CGDN)
Dr. Philip Hieter, University of British Columbia
Dr. Bartha Knoppers, Université de Montréal
Dr. Robert Korneluk, Children's Hospital of Eastern Ontario
Dr. François Rousseau, Université Laval
New Principal Investigators
Dr. Geoff Hicks, University of Manitoba (Chair)
Dr. Susan E. Andrew, University of Alberta
Dr. Benoit Bruneau, Hospital for Sick Children
Dr. Nancy Hawkins, Simon Fraser University
Dr. Josée Lavoie, Université Laval
Public Engagement and Knowledge Exchange
Dr. François Rousseau, Université Laval (Chair)
Dr. Judith Bray, CIHR
Dr. Béatrice Godard, Université de Montréal
Dr. Jane Green, Memorial University of Newfoundland
Dr. Michael Hayden, University of British Columbia
Ms. Suzanne Lawson, ALS Society of Canada
Dr. Michael Robb, University of Alberta
Dr. Julien Veilleux, Ministère de la santé et des services sociaux
Voluntary Health Organizations Working Group
Ms. Suzanne Lawson, ALS Society of Canada (Co-Chair)
Mr. Yves Savoie, Muscular Dystrophy Association of Canada (Co-Chair)
Mr. Cliff Carr, Batten Disease Support and Research Association
Ms. Sharon Colle, Foundation Fighting Blindness - Canada
Ms. Judi Farrell, Lupus Canada
Dr. Alison M. Stephen, Heart and Stroke Foundation of Canada
Ms. Doretta Thompson, ALS Society of Canada
| Summary | Competition Deadline | Applications Received (#) | Applications Approved (#) | Success Rate (%) |
| This program is designed to promote the engagement of Canadian scientists in research projects to advance research tools and techniques in a broad sense, where invention and development, rather than discovery, is expected to be the essence of those projects. | October 2002 | 23 (8 IG related) |
11 (4 IG related) |
50 |
| HU, Jim Hospital for Sick Children |
A new genetic tool for mutational analysis of genes in mammalian cells and in animals | $294,017 over three years |
| KAST, Juergen University of British Columbia |
Development of a mass spectrometry-based method for full-length sequencing of proteins | $283,386 over three years |
| RANCOURT, Derrick University of Calgary |
Development of a mouse gene rheostat | $286,710 over three years |
| WOOLLEY, Andrew University of Toronto |
Fluorescent tools for detecting protein-protein interactions | $135,880 over three years |
| Summary | Competition Deadline | Applications Received (#) | Applications Approved (#) | Success Rate (%) |
| The purpose of this New Discoveries - Seed Grants program is to encourage novel, innovative, and inventive research. | October 2002 | 10 (8 IG related) |
5 (4 IG related) |
50 |
| BARKER, Philip Montreal Neurological Institute |
MAGE genes and Autism | $114,000 over two years |
| BOOTH, Stephanie Canadian Science Centre for Human and Animal Health SOMORJAI, Rajmund L Institute for Biodiagnostics, NRC |
Microarray expression profiling in prion induced neurodegenerative diseases using novel statistical classification strategies | $119,252 over two years |
| TIELEMAN, Dirk University of Calgary |
Computer modeling of ABC-transporter domains | $77,500 over two years |
| WOOLLEY, Andrew University of Toronto |
Fluorescence imaging of ion channels in action | $104,000 over two years |
| Summary | Competition Deadline | Applications Received (#) | Applications Approved (#) | Success Rate (%) |
| This initiative will support critical analysis of current ethical, legal and social practices involving population-based genetic research as well as implications for future studies in Canada. | November 2002 | 11 | 6 | 55 |
| HOY, Michael University of Guelph |
Impact on consumer welfare of genetic testing in insurance markets | $35,000 over one year |
| KNOPPERS, Bartha M Université de Montréal |
Towards a common language for biobanking? | $28,600 over one year |
| LEE, Robert C Calgary Health Region |
A systematic review of the social, ethical, and legal dimensions of genomic and proteomic cancer risk assessment and screening technologies | $34,300 over one year |
| LOCK, Margaret M McGill University |
The consumer DNA profiling industry: The production of bodily commodities, explanatory narratives and uncertainty |
$40,237 over one year |
| MILLER, Fiona McMaster University |
Re-defining disease: Molecular genetics, ethics and health system implications |
$74,960 over one year |
| PULLMAN, Daryl Memorial University of Newfoundland LATUS, Andrew M Memorial University of Newfoundland |
Benefit sharing: Commercial sponsors' perspectives | $34,900 over one year |
| Summary | Competition Deadline | Applications Received (#) | Applications Approved (#) | Success Rate (%) |
| This award provides two years of protected research time to pursue clinical or translational research. | July 2002 | 4 | 2 | 50 |
| ARBOUR, Laura University of British Columbia |
The genetic and environmental bases of two complex diseases in the First Nations People of British Columbia | $240,000 over two years |
| LEWIS, M.E. Suzanne University of British Columbia |
New approaches toward understanding the genetic bases of form function and phenotype in Autism Spectrum Disorder | $240,000 over two years |
| Summary | Competition Deadline | Applications Received (#) | Applications Approved (#) | Success Rate (%) |
| This award provides support for MD/PhD students with a research focus in the areas of genetics. | July 2002 | 6 | 6 | 100 |
| CARLSON, Christopher University of Alberta |
Characterization of Cox15p in heme metabolism and its role in COX deficiencies | |
| DOLGETTA, Speranza University of Calgary |
Germ line engineering - Ethical aspects and public policy | $123,000 over six years |
| HYRCZA, Martin University of Toronto |
A functional genomics approach to elucidate the molecular mechanisms of T cell dysfunction in HIV-1/AIDS | $123,000 over six years |
| LEVESQUE, Sébastien Université Laval |
Identification des gènes de susceptibilité à la préeclampsie | $123,000 over six years |
| MAYNES, Jason University of Alberta |
Identification of potential drug targets in mycobacterium tuberculosis | $123,000 over six years |
| ST-PIERRE, Julie Université Laval |
Genetic study of intermediate phenotypes in type 2 diabetes mellitus and its cardiovascular-associated complications in the Saguenay-Lac-St. Jean population | $123,000 over six years |
| Summary | Competition Deadline | Applications Received (#) | Applications Approved (#) | Success Rate (%) |
| These grants will enhance the capacity of groups of researchers to: (a) create strong intra- and inter-institution mentoring arrangements, and (b) developing knowledge translation. | October 2002 | 3 | 2 | 66 |
| BATTISTA, Renaldo N McGill University |
Programme de recherche en appui aux politiques de santé en génétique dans un souci de qualité, d'efficience et de bien-être social. | $1,000,000 over five years |
| WILSON, Brenda J University of Ottawa CAULFIELD, Timothy University of Alberta WELLS, George A University of Ottawa |
Translating genetics discoveries into appropriate health policy and services: Enhancing research capacity and developing an interdisciplinary approach. | $998,668 over five years |
| Summary | Competition Deadline | Applications Received (#) | Applications Approved (#) | Success Rate (%) |
| These grants facilitate cross-disciplinary training by giving biomedical and health researchers financial support for short-term visits (three months or less) to research centres within Canada and abroad. | February 2002 | 12 | 10 | 83 |
| June 2002 | 23 | 14 | 61 | |
| October 2002 | 11 | 6 | 55 |
| BARR, Cathy L University Health Network |
Quantitative trait analysis of cognitive and behavioural phenotypes in clinical and population based samples | $10,000 over three months |
| BROCK, Hugh W University of British Columbia |
Short-term exchange to learn mammalian tissue-culture and chromatin analysis techniques | $10,000 over three months |
| GIACOMINI, Mita McMaster University |
Incorporating ethical analysis of values into genetic services coverage policies | $10,000 over three months |
| LANDRY, Josette-Renée Terry Fox Laboratory |
Participation in the Canadian Bioinformatics workshops series to facilitate the analysis of human retroelements involved in gene regulation | $10,000 over six months |
| MAYNES, Jason T University of Alberta |
Deriving constraints from low resolution X-ray data for the prediction of protein structures from myobacterium tuberculosis | 7,860 over three months |
| RAJCAN-SEPAROVIC, Evica B.C.'s Children's Hospital |
High resolution whole genome analysis of recurrent spontaneous abortions | $4,540 over one month |
| SHAW, Gary S University of Western Ontario |
Folding and misfolding of disease-related proteins | $7,160 over three months |
| VACHER, Jean Institut de recherches cliniques de Montréal |
Molecular signaling pathway in pheomelanogenesis | $6,600 over one month |
| WEVRICK, Rachel University of Alberta |
Investigation of the zebrafish homologue of necdin, a candidate gene for Prader-Willi syndrome | $8,610 over three months |
| WILHELM, Brian University of British Columbia |
Bioinformatics training at the workshop on molecular evolution | $2,100 over one month |
| BRAZAS, Michelle University of British Columbia |
Genomic analysis of the antibiotic resistance of pseudomonas aeurginosa | $3,000 over one month |
| CAMPBELL, Graeme University of British Columbia |
Canadian bioinformatics workshop: Genomics workshop | $3,000 over one month |
| CAMPBELL, Marcia University of Alberta |
Analysis of chromosomal and karyotype instability in mismatch repair deficient murine thymic lymphomas | $3,987 over three months |
| CASEY, Joseph University of Alberta |
Renal phenotype of NBC3 sodium bicarbonate co- transporter gene (SLC4A7) knock-out mice | $8,640 over three months |
| CHABAN, Bonnie University of Saskatchewan |
CGDN Canadian genetic diseases network 2002 CBW Canadian bioinformatics workshop genomics workshop | $3,000 over one month |
| DEVON, Rebecca University of British Columbia |
Attendance at bioinformatics genomics workshop | $3,000 over one month |
| EVERITT, Rebecca University of Calgary |
Analysis management and dissemination of sequences from mouse embryonic stem cells | $3,000 over one month |
| FOX, Joanne University of Calgary |
Canadian bioinformatics workshop series: Genomics 2002 | $3,000 over one month |
| GRAHAM, Laurie Queen's University |
Canadian bioinformatics workshops-genomics université de Montréal sponsored by the Canadian genetic diseases network | $2,507 over one month |
| LEE, Chow University of Northern British Columbia |
Inactivation of c-myc and MDR mRNA expression using ribonuclease P and external guide sequences | $9,850 over three months |
| LITHWICK, Stuart Hospital for Sick Children |
Canadian genetic disease network: Canadian bioinformatics workshops-genomics workshops | $2,500 over one month |
| LIU, Songyan University of Manitoba |
Analysis and management of DNA sequences disrupted by tagged sequence mutagenesis from mouse embryonic stem cells | $7,742 over three months |
| SCHAERPF, Manuela University of British Columbia |
Genomics workshop part of the Canadian genetic diseases network sponsored Canadian bioinformatics workshop series |
$3,000 |
| TANGEN, Kristin University of British Columbia |
Genomics workshop | $3,000 over one month |
| BELL, Alexander McGill University |
Preliminary linkage analysis of a naturally occurring recessive circadian entrainment mutation in California mice (peromyscus californicus) | $11,000 over six months |
| DE GROOT, Marlene Dalhousie University |
Participation in the Canadian bioinformatics workshop series, to facilitate genetic and genomic analysis of programmed cell death in a model organism. | $10,411 over six months |
| FREEMAN, John |
Canadian bioinformatics workshop | $4,200 over three months |
| LIAM, Brunham University of British Columbia |
Valuing the sweetness of blood: an anthropological analysis of genetic knowledge about diabetes and its societal implications | $4,810 over three months |
| ROCK, Melanie York University |
CGDN Canadian Bioinformatics Workshop series | $5,462 over three months |
| WILHELM, Brian University of British Columbia |
Preliminary linkage analysis of a naturally occurring recessive circadian entrainment mutation in California mice (peromyscus californicus) | $2,600 over one month |
| Summary | Competition Deadline | Applications Received (#) | Applications Approved (#) | Success Rate (%) |
| These awards support career transition of faculty members who are planning to undertake rigorous training outside of their primary area of expertise in order to transition into an area of need identified by the IG community. | October 2002 |
2 | 1 | 50 |
| WILD, Gary E McGill University |
The identification of inflammatory bowel disease alleles using haplotype analysis | $80,000 over one year |
| Summary | Competition Deadline | Applications Received (#) | Applications Approved (#) | Success Rate (%) |
| By subsidizing the database licensing fee, this program enables more researchers to access Celera's proprietary genomic database. | May 2002 | 21 | 15 | 71 |
| November 2002 |
4 | 2 | 50 |
| BARBER Dwayne Ontario Cancer Institute |
Identification of novel genes involved in normal and leukemogenic hemapoiesis | $18,000 over three years |
| BULMAN, Dennis Ottawa Hospital Research Institute |
Celera genome database grant | $18,000 over three years |
| DER, Sandy University of Toronto |
Utility of Celera database in the analysis of microarray mRNA expression data ant the development of novel gene promoter/CpG island DNA microarrays | $18,000 over three years |
| GROS, Philippe McGill University |
A genetic approach to understand host defenses against infections | $18,000 over three years |
| HAYDEN, Michael R University of British Columbia |
Celera genome database | $18,000 over three years |
| HICKS, Geoffrey University of Manitoba |
Bioinformatic analysis to identify defined embryonic stem cell mutations in genetic determinants of human disease and cancer | $18,000 over three years |
| MAGER, Dixie University of British Columbia |
Use of Celera database to facilitate mammalian genomic studies | $18,000 over three years |
| RANCOURT, Derrick University of Calgary |
Mitochondrial genetics | $18,000 over three years |
| SCHRADER, John University of British Columbia |
Celera genome database | $18,000 over three years |
| SHOUBRIDGE, Eric A McGill University |
Mitochondrial genetics | $18,000 over three years |
| STEWART, Alexander K Princess Margaret Hospital (Toronto) |
Celera genome database as a tool for studies in the biology of multiple myeloma and in the characterization of novel lipase genes | $18,000 over three years |
| SIRARD, Marc-André Université Laval |
Conservation inter-espèces des bases moléculaires de l'oogenèse | $18,000 over three years |
| TONIN, Patricia N McGill University |
Celera genome database grant | $18,000 over three years |
| TREMBLAY, Michel L McGill University |
Use of the CELERA database in the identification of new human cancer suppressor genes and in the functional analysis of the protein tyrosine phosphatase gene family | $18,000 over three years |
| WROGEMANN, Klaus University of Manitoba |
A genetic approach to understand host defenses against infections | $18,000 over three years |
| HEGELE, Robert A John P. Robarts Research Institute |
Celera genome database initiative | $18,000 over three years |
| SIMINOVITCH, Katherine University Health Network (Toronto) |
Identification of genes underlying immunological diseases | $18,000 over three years |
| DANSKA, Jayne Hospital for Sick Children |
Control of Type 1 Diabetes pathogenesis by Idd4 and Idd11 |
$178,662 over one year |
| EVANS, Jane University of Manitoba |
Numerical, clinical and epidemiological approaches to complex patterns of human malformations | $72,610 over one year |
| HUGHES, Timothy University of Toronto |
A proactive bioinformatics system for genome-scale hypothesis testing | $95,760 over one year |
| JURILOFF, Diana University of British Columbia |
Genetic and developmental studies of a mouse model of genetically multifactorial neural tube defects | $117,009 over one year |
| RAHMAN, Proton Memorial University of Newfoundland |
Disease related genes in psoriatic arthritis | $130,464 over one year |
| ROBERT, Jason S Dalhousie University |
Conceptual and ethical issues at the intersection of genomics, developmental biology, ecology, and health - II | $17,910 over one year |
| ROGER, Andrew J Dalhousie University |
The origin and early evolution of gene families and organelles in eukaryotes | $102,759 over one year |
| ROUSSEAU, François Université Laval |
Validation de marqueurs génétiques de la préeclampsie | $88,884 over one year |
| ROUSSEAU, François Université Laval |
Validation of genetic markers of the risk of sporadic breast cancer using a large matched case-control study | $168,493 over one year |
| TIELEMAN, Dirk P University of Calgary |
Theoretical approaches to membrane protein structure: Molecular simulation and computer modeling of helical membrane proteins and peptides | $38,000 over one year |
| GREENBLATT, Jack University of Toronto |
Banting and Best Department of Medical Research Genomic Infrastructure Report | $55,242 over one year |
| JOHNSTON, Gerald Dalhousie University |
A robotics facility for genome-wide genetic analysis | $298,855 over three years |
| LIPSHITZ, Howard University of Toronto |
Functional analysis of the drosophila genome using DNA microarrays | $449,956 over three years |
| MARCEAU, Normand Université Laval |
Maintenance of a cell imaging core facility | $479,103 over five years |
| PRESLEY, John McGill University |
McGill confocal microscopy centres: Consolidated maintenance and equipment grant | $234,678 over three years |
| RAYMOND, Martine Institut de recherches cliniques de Montréal |
Equipment/maintenance for the IRCM molecular biology facility | $258,155 over three years |
| RODER, John Samuel Lunenfeld Research Institute |
Place cell equipment grant | $102,066 over one year |
| VOGEL, Hans University of Calgary |
Maintenance of bio-NMR centre | $597,828 over five years |
| DEGAARD, Kurt McGill University |
Molecular mechanisms of transmembrane proteins in the exocytic and endocytic pathways | $41,500 over one year |
| GAGNON, Cynthia Hôpital de Jonquière |
Conséquences fonctionnelles et sociales de la dystrophie myotonique : Impact des facteurs personnels et environnementaux sur la participation sociale | $41,500 over one year |
| GARENC, Christophe Université de Lausanne |
Role of PPARs in lipase gene expression in adipocytes, monocytes and macrophages: Physiopathological and therapeutic pathways | $41,500 over one year |
| LAGNEUX, Caroline McGill University |
The genetic dissection of stroke in the mouse model | $41,500 over one year |
| PETRYSHEN, Tracey Whitehead Institute Biomedical Research |
Identification of sensorimotor gating genes by mouse DNA microarray gene expression studies | $46,500 over one year |
| ROY, Marie-France McGill University |
Study of the role of toll-like receptor 4 (tlr4) in the host inflammatory response of the mnd mouse mutant | $51,000 over one year |
| Summary | Competition Deadline | Applications Received (#) | Applications Approved (#) | Success Rate (%) |
| General call: IG specific objectives of this program were to integrate an understanding of KT principles and practice into the training of health professionals.
Special Topic: Folic Acid and the Prevention of Birth Defects (In partnership with IAPH, IGH and INMD) |
October 2002 |
3 | 2 | 67 |
| October 2002 |
1 | 1 | 100 TD> |
| CARROLL, June C Mount Sinai Hospital ALLANSON, Judith Children's Hospital of Eastern Ontario WILSON, Brenda University of Ottawa |
Evaluation of the impact of a multifaceted intervention to enhance the delivery of genetics services by family physicians | $282,964 over three years |
| WILSON, Brenda J University of Ottawa |
The public and genetics: Understanding, expectations and priorities | $172,336 over two years |
| ST-CYR TRIBBLE, Denise Université de Sherbrooke |
Application des connaissances liées à l'acide folique dans la prévention des anomalies congénitales : évaluation de l'implantation d'un programme et des effets sur les pratiques professionnelles | $ 251,027 over three years |
Research Capacity Building
| Strategic Training Program | Partners: |
| Alberta Heritage Foundation for Health Research Canadian Institutes of Health Research (CIHR) Heart and Stroke Foundation of Canada Institute of Aboriginal Peoples' Health Institute of Cancer Research Institute of Circulatory and Respiratory Health Institute of Gender and Health Institute of Genetics Institute of Health Services and Policy Research Institute of Human Development, Child and Youth Institute of Infection and Immunity Institute of Neurosciences, Mental Health and Addiction Institute of Nutrition, Metabolism and Diabetes CIHR Knowledge Translation Branch Fonds de recherche en santé du Québec (FRSQ) Michael Smith Foundation for Health Research |
| Graham Cote | Queen's University | Queen's University proteomics and protein function discovery training program | $1,478,710 over five years |
| Walid Houry | University of Toronto | Training program in protein folding: Principles and diseases | $1,800,000 over six years |
| Steven Jones | B.C. Cancer Research Centre | Bioinformatics training for health research | $1,800,000 over six years |
| Sabine Mai | University of Manitoba | Innovative technologies in multidisciplinary health research training | $1,800,000 over six years |
| Stephen Meyn | University of Toronto | Collaborative graduate program in molecular medicine | $1,800,000 over six years |
| Reinhart Reithmeier | University of Toronto | Training program in structural biology of membrane proteins linked to disease | $1,800,000 over six years |
| David Thomas | McGill University | CIHR strategic training program in chemical biology | $1,770,000 over six years |
| James Cross | University of Calgary | Training program in genetics, child development and health | $1,469,160 over six years |
| Jocelyn Downie | Dalhousie University | Training program in health law & policy | $1,575,000 over six years |
| Aaron Fenster |
John P. Robarts Research Institute |
Vascular and cerebrovascular transdisciplinary training program (vcTTP): Integrated training in genetics, biology, mathematics, physics and engineering towards an understanding and prevention of vascular and cerebrovascular disease |
$1,075,000 over five years |
| Fernand Labrie de l'Université Laval | Centre hospitalier endocriniennes | Génomique fonctionnelle et maladies | $1,680,000 over six years |
| Peter Liu | University of Toronto | A training program in cardiovascular research: Molecules to populations, heart failure to prevention | $1,410,000 over six years |
| Stephen Lye | Mount Sinai Hospital | The Samuel Lunenfeld Research Institute training program: Applying genomics to human health | $1,800,000 over six years |
| Michael McDonald | University of British Columbia | Training program in ethics of health research | $1,599,782 over six years |
| Norman Rosenblum | Hospital for Sick Children | Canadian child and youth health research clinician-scientist development program (CCYHR-CSDP) | $1,800,000 over six years |
| Competition Deadline: November 2001 | |||
| Stephane Flibotte | Simon Fraser University | Bioinformatics and comparable genomics | $80,000 over one year |
| Joseph Pegna |
École Polytechnique de Montréal |
Exploratory training toward a capacity in biomedical nanotechnologies |
$70,000 over one year |
| David Hogg | University of Toronto | Bioinformatics and software engineering | $80,000 over one year |
| Ann Robertson | University of Toronto | The meaning and use of genetic risk as evidence: Policy and practice issues at the intersection of human genomics, public health and bioethics | $68,333 over ten months |
| Date & Location | Event | Financial Contribution ($) Fiscal Year 2002-03 |
| April 4-7, 2002 (Mont Tremblant, Quebec) | 1st Canadian Developmental Biology Meeting | 16,440 |
| May 11-14, 2002 (Edmonton, Alberta) | 2nd International Conference of The Canadian Proteomics Initiative (PENCE) | 30,000 |
| June 2, 2002 (Toronto, Ontario) | Vision Health Research Council (VHRC) Meeting | 5,000 |
| June 3, 2002 (Toronto, Ontario) | Foundation Fighting Blindness Scientific Meeting | 5,000 |
| June 6-8, 2002 (Toronto, Ontario) | Genomics and Public Policy Symposium | 8,161 |
| September 5-8, 2002 (Montreal, Quebec) | 3rd DNA Sampling Conference | 10,000 |
| September 19-20, 2002 (Vancouver, British Columbia) | 1st Pacific North-West Cell Signalling Conference | 5,000 |
| October 23-25, 2002 (Ottawa, Ontario) | National Workshop on Autism | 5,000 |
| November 9, 2002 (Vancouver, British Columbia) |
Genetic Testing: Help, Hope or Hype? Workshop | 5,000 |
| November 26-28, 2002 (Montreal, Quebec) | 9th UNESCO IBC Meeting | 5,000 |
| February 27- March 1, 2003 (Antigonish, Nova Scotia) | 1st Canadian National Undergraduate Bioethics Conference | 10,000 |
| March 27-28, 2003 (Vancouver, British Columbia) |
Technology Enabled Knowledge Translation Workshop (TEKT) | 5,000 |
| April 25-26, 2003 (Kananaskis, Calgary) | Crossing Over: Genomics in the Public Sphere Workshop | 10,000 |
| May 3, 2003 (Denver, Colorado) | Genomic Approaches to the Immune System | 5,000 |
| May 8-9, 2003 (Montreal, Quebec) | Von Willebrand Disease Conference | 5,000 |
| May 13-14, 2003 (Winnipeg, Manitoba) | Canadian Student Health Research Forum | 5,000 |
| June 16-17, 2003 (Toronto, Ontario) | 2nd International Congress on Schwachman-Diamond Syndrome | 5,000 |
| July 20-24, 2003 (Toronto, Ontario) | International Union of Biochemistry and Molecular Biology (IUBMB) 2003 | 25,000 |
| August 7-12, 2003 (Vancouver, British Columbia) |
Morphogenesis and Malformation Workshop | 10,000 |
| Total Contribution in FY 2002-03 | $174,601 |
