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MATERIAL SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT NAME: Mayaro virus SYNONYM OR CROSS REFERENCE: Epidemic polyarthritis and rash, Mayaro fever, MAY CHARACTERISTICS: Togaviridae (formerly group A arboviruses), genus Alphavirus; spherical, enveloped virions 60 nm in diameter, single-stranded, positive-sense RNA genome SECTION II - HEALTH HAZARD PATHOGENICITY: Self limiting febrile viral disease; characterized by arthralgia or arthritis typically in the knee, ankle and small joints of the extremities, followed by a maculopapular rash; buccal and palatal enanthea can occur; Inapperent infections are common, immunity is long lasting EPIDEMIOLOGY: Found in south and central America HOST RANGE: Humans, primates, other mammals, birds INFECTIOUS DOSE: Not known MODE OF TRANSMISSION: By bite of an infective mosquito INCUBATION PERIOD: Usually 3-11 days COMMUNICABILITY: No evidence of person-to-person transmission SECTION III - DISSEMINATION RESERVOIR: Most likely primates ZOONOSIS: Probable - most likely from primates which generate high viremia but manifest no disease VECTORS: Mosquitoes - Haemogogus spp. SECTION IV - VIABILITY DRUG SUSCEPTIBILITY: No antiviral available to date SUSCEPTIBILITY TO DISINFECTANTS: Sensitive to 70% ethanol, 1% sodium hypochlorite, 2% glutaraldehyde, Sensitive to lipid solvents PHYSICAL INACTIVATION: Inactivated by moist, dry heat > 58o C; sensitive to drying SURVIVAL OUTSIDE HOST: Unknown, less than one day in culture medium at 37o C SECTION V - MEDICAL SURVEILLANCE: Monitor for symptoms; confirm by serological analysis and viral isolation in tissue culture (vero cells) FIRST AID/TREATMENT: Mainly supportive therapy IMMUNIZATION: None available to date PROPHYLAXIS: None available SECTION VI - LABORATORY HAZARDS LABORATORY-ACQUIRED INFECTIONS: At least 6 reported cases SOURCES/SPECIMENS: Blood PRIMARY HAZARDS: Accidental parenteral inoculation, aerosols SPECIAL HAZARDS: None SECTION VII - RECOMMENDED PRECAUTIONS CONTAINMENT REQUIREMENTS: Biosafety level 2 practices and containment equipment for all activities involving the virus and potentially infectious body fluids or tissues PROTECTIVE CLOTHING: Laboratory coat; gloves when skin contact with infectious materials is unavoidable OTHER PRECAUTIONS: Frequent handwashing SECTION VIII - HANDLING INFORMATION SPILLS: Allow aerosols to settle; wearing protective clothing gently cover the spill with absorbent paper towel and apply 1% sodium hypochlorite starting at the perimeter and working towards the center; allow sufficient contact time (30 min) before clean up DISPOSAL: Decontaminate all wastes before disposal; steam sterilization, chemical disinfection, incineration STORAGE: In sealed containers that are appropriately labelled SECTION IX - MISCELLANEOUS INFORMATION Date prepared: March, 2001 Prepared by: Office of Laboratory Security, PHAC Although the information, opinions and recommendations contained in this Material Safety Data Sheet are compiled from sources believed to be reliable, we accept no responsibility for the accuracy, sufficiency, or reliability or for any loss or injury resulting from the use of the information. Newly discovered hazards are frequent and this information may not be completely up to date. Copyright © [Material Safety Data Sheets - Index]
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Last Updated: 2001-04-23 | ![]() |