![]() |
|||||||||||||||||
![]() |
|||||||||||||||||
![]() ![]() ![]() |
![]() |
|
|||||||||||||||
![]() |
![]() |
MATERIAL SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT NAME: Escherichia coli, enterotoxigenic SYNONYM OR CROSS REFERENCE: ETEC, traveller's diarrhea, gastroenteritis CHARACTERISTICS: Gram negative rod; motile, aerobic; produces a heat labile enterotoxin (LT) and a heat stabile enterotoxin (ST) SECTION II - HEALTH HAZARD PATHOGENICITY: Self-limiting cholera-like disease in infants and adults; profuse watery diarrhea without blood or mucous; abdominal cramping, vomiting, acidosis, prostration, malaise and dehydration can occur; fever may or may not be present; symptoms usually lasts fewer than 5 days EPIDEMIOLOGY: Usually sporadic, particularly in underdeveloped countries; may cause common source outbreaks; one of two major leading causes of diarrhea in children in developing countries; has become the leading bacterial cause of gastroenteritis outbreaks on cruise ships; accounts for 40-60% of all cases of traveller's diarrhea HOST RANGE: Humans, livestock, most mammals; species specific, no known non - human hosts for human ETEC INFECTIOUS DOSE: 100,000,000 organisms to 10,000,000,000 organisms (108 to 1010 ) by ingestion MODE OF TRANSMISSION: Fecal-oral route; poor sanitation; fecal contamination of food, water or fomites; poor personal hygiene INCUBATION PERIOD: 24-72 hours COMMUNICABILITY: Communicable for duration of fecal excretion (several weeks) SECTION III - DISSEMINATION RESERVOIR: Humans, animals; ETEC infections are largely species specific; humans constitute the reservoir for strains causing diarrhea in humans ZOONOSIS: No VECTORS: None SECTION IV - VIABILITY DRUG SUSCEPTIBILITY: Sensitive to wide spectrum of antibiotics; quinolines first choice treatment worldwide DRUG RESISTANCE: tetracyclines, trimethroprim-sulfamethorazole approximately 40% SUSCEPTIBILITY TO DISINFECTANTS: Susceptible to many disinfectants - 1% sodium hypochlorite, 70% ethanol, glutaraldehyde, iodines, phenolics, formaldehyde PHYSICAL INACTIVATION: Inactivated by moist heat (121° C for at least 15 min) and dry heat (160-170° C for at least 1 hour) SURVIVAL OUTSIDE HOST: Dust 4 to 27 days; feces - up to 84 days; fingertip - 45 min; soil - up to 84 days SECTION V - MEDICAL SURVEILLANCE: Monitor for symptoms; confirm bacteriologically FIRST AID/TREATMENT: Electrolyte fluid therapy (oral or IV); antibiotics may be administered in very severe cases IMMUNIZATION: oral vaccine under development PROPHYLAXIS: Short term antibiotic therapy with TMP-SMX or doxycycline for travellers going to high-risk areas with no safe food or water SECTION VI - LABORATORY HAZARDS LABORATORY-ACQUIRED INFECTIONS: 2 reported cases of laboratory infections with E. coli SOURCES/SPECIMENS: Feces; contaminated food, water, fomites PRIMARY HAZARDS: Ingestion SPECIAL HAZARDS: None SECTION VII - RECOMMENDED PRECAUTIONS CONTAINMENT REQUIREMENTS: Biosafety level 2 practices, containment equipment and facilities for activities involving cultures and infected clinical materials PROTECTIVE CLOTHING: Laboratory coat; gloves when contact with infectious materials is unavoidable OTHER PRECAUTIONS: Good personal hygiene and frequent handwashing SECTION VIII - HANDLING INFORMATION SPILLS: Allow aerosols to settle; wearing protective clothing, gently cover spill with absorbent paper towel and apply 1% sodium hypochlorite, starting at perimeter and working towards the centre; allow sufficient contact time (30 min) before clean up DISPOSAL: Decontaminate before disposal; steam sterilization, chemical disinfection STORAGE: In sealed containers that are appropriately labelled SECTION IX - MISCELLANEOUS INFORMATION Date prepared: January, 2001 Prepared by: Office of Laboratory Security, PHAC Although the information, opinions and recommendations contained in this Material Safety Data Sheet are compiled from sources believed to be reliable, we accept no responsibility for the accuracy, sufficiency, or reliability or for any loss or injury resulting from the use of the information. Newly discovered hazards are frequent and this information may not be completely up to date. Copyright © [Material Safety Data Sheets - Index]
|
![]() |
|||
![]() |
Last Updated: 2001-09-27 | ![]() |