Priority Substances List Assessment Report for 2-Buthoxyethanol

Environment Canada
Health Canada
2002
ISBN: 0-662-33597-X
Cat. no.: En40-215/66E

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(403K)

Canadian Environmental Protection Act 1999

Table of Contents

• Addendum
• List of Acronyms and Abbreviations
• Synopsis
• 1.0 Introduction
• 2.0 Summary of Information Critical to Assessment of "Toxic" Under CEPA 1999
  • 2.1 Identity and physical/chemical properties
  • 2.2 Entry characterization
    • 2.2.1 Production, importation and uses
    • 2.2.2 Sources and releases
      • 2.2.2.1 Natural sources
      • 2.2.2.2 Anthropogenic sources
  • 2.3 Exposure characterization
    • 2.3.1 Environmental fate
      • 2.3.1.1 Air
      • 2.3.1.2 Water
      • 2.3.1.3 Soils
      • 2.3.1.4 Biota
      • 2.3.1.5 Environmental distribution
    • 2.3.2 Environmental concentrations
      • 2.3.2.1 Multimedia exposure study
      • 2.3.2.2 Ambient air
      • 2.3.2.3 Indoor air
      • 2.3.2.4 Surface water
      • 2.3.2.5 Groundwater
      • 2.3.2.6 Drinking water
      • 2.3.2.7 Soil
      • 2.3.2.8 Food
      • 2.3.2.9 Consumer products
      • 2.3.2.10 Fugacity modelling
  • 2.4 Effects characterization
    • 2.4.1 Ecotoxicology
      • 2.4.1.1 Terrestrial organisms
      • 2.4.1.2 Aquatic organisms
    • 2.4.2 Abiotic atmospheric effects
    • 2.4.3 Experimental animals and in vitro
      • 2.4.3.1 Kinetics and metabolism
      • 2.4.3.2 Acute toxicity
      • 2.4.3.3 Short-term toxicity
      • 2.4.3.4 Subchronic toxicity
        • 2.4.3.4.1 Oral
        • 2.4.3.4.2 Inhalation
        • 2.4.3.4.3 Dermal
      • 2.4.3.5 Chronic toxicity and carcinogenicity
      • 2.4.3.6 Genotoxicity
      • 2.4.3.7 Developmental and reproductive toxicity
      • 2.4.3.8 Immunotoxicity
      • 2.4.3.9 Neurotoxicity
      • 2.4.3.10 Investigations of hemolysis in in vitro systems
      • 2.4.3.11 Toxicokinetics and Mode of Action
  • 2.4.4 Humans
• 3.0 Aseessment oF "TOXIC" Under CEPA 1999
  • 3.1 CEPA 1999 64(a): Environment
    • 3.1.1 Assessment endpoints
    • 3.1.2 Environmental risk assessment
      • 3.1.2.1 Terrestrial organisms
        • 3.1.2.1.1 Wildlife
        • 3.1.2.1.2 Soil organisms
      • 3.1.2.2 Aquatic organisms
      • 3.1.2.3 Discussion of uncertainty
  • 3.2 CEPA 1999 64(b): Environment upon which life depends
  • 3.3 CEPA 1999 64(c): Human health
    • 3.3.1 Estimates of potential exposure in humans
    • 3.3.2 Human health risk characterization
      • 3.3.2.1 Hematological effects
      • 3.3.2.2 Other non-neoplastic effects
      • 3.3.2.3 Carcinogenicity and genotoxicity
    • 3.3.3 Exposure-response analyses
      • 3.3.3.1 Hematological effects
      • 3.3.3.2 Other (non-hematological) effects
    • 3.3.4 Risk characterization
    • 3.3.5 Uncertainties and degree of confidence in the human health risk characterization
  • 3.4 Conclusions
  • 3.5 Considerations for follow-up (further action)
• 4.0 References
• Appendix A Search Strategies Employed for Identification of Relevant Data

List of Tables

• Table 1 - Effects of concentration and time on hematocrit and the concentration of free plasma hemoglobin in rat blood incubated with butoxyacetic acid (BAA) in vitro
• Table 2 Effects of concentration, time and sex on hematocrit and the concentration of free plasma hemoglobin in human blood incubated with butoxyacetic acid (BAA) in vitro
• Table 3 Estimated average intake of 2-butoxyethanol by six age groups in the general population
• Table 4 Estimates of exposure to 2-butoxyethanol through inhalation and dermal uptake from use of household cleaning products
• Table 5 BMC₀₅s and model fitting information for hematological effects in mice
• Table 6 BMC₀₅s and model fitting information for hematological effects in rats
• Table 7 BMC₀₅s and model fitting information for other non-hematological endpoints

List of Figures

• Figure 1 Exposure-response curves for hematological effects in mice and rats
• Figure 2 Exposure-response curves for non-hematological effects in mice and rats