Priority Substances List Assessment Report for

Environment Canada
Health Canada
2000
ISBN: 0-662-28575-1
Cat. No.: En 40-215/48E

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(413K)

Canadian Environmental Protection Act 1999

Table of Contents

• List of Acronyms and Abbreviations
• Synopsis
• 1.0 Introduction
• 2.0 Summary of Information Critical to Assessment of "Toxic" Under CEPA 1999
  • 2.1 Identity and physical/chemical properties
  • 2.2 Entry characterization
    • 2.2.1 Production, uses and importation
    • 2.2.2 Sources and releases
      • 2.2.2.1 Natural sources
      • 2.2.2.2 Anthropogenic sources
  • 2.3 Exposure characterization
    • 2.3.1 Environmental fate
      • 2.3.1.1 Air
      • 2.3.1.2 Water
      • 2.3.1.3 Sediment
      • 2.3.1.4 Soil
      • 2.3.1.5 Biota
      • 2.3.1.6 Environmental partitioning
    • 2.3.2 Environmental concentrations
      • 2.3.2.1 Ambient air
      • 2.3.2.2 Indoor air
      • 2.3.2.3 Drinking water
      • 2.3.2.4 Surface water
      • 2.3.2.5 Sediment and soil
      • 2.3.2.6 Biota
      • 2.3.2.7 Food
  • 2.4 Effects characterization
    • 2.4.1 Ecotoxicology
      • 2.4.1.1 Aquatic organisms
      • 2.4.1.2 Terrestrial organisms
    • 2.4.2 Abiotic atmospheric effects
    • 2.4.3 Experimental animals and in vitro
      • 2.4.3.1 Acute toxicity
      • 2.4.3.2 Irritation and sensitization
      • 2.4.3.3 Short-term and subchronic toxicity
        • 2.4.3.3.1 Inhalation
        • 2.4.3.3.2 Ingestion
        • 2.4.3.3.3 Dermal exposure
      • 2.4.3.4 Chronic toxicity and carcinogenicity
      • 2.4.3.5 Genotoxicity
      • 2.4.3.6 Reproductive and developmental toxicity
      • 2.4.3.7 Neurological effects and effects on the immune system
      • 2.4.3.8 Toxicokinetics and mechanism of action
    • 2.4.4 Humans
• 3.0 Aseessment oF "TOXIC" Under CEPA 1999
  • 3.1 CEPA 1999 64(a): Environment
    • 3.1.1 Assessment endpoints
    • 3.1.2 Environmental risk characterization
      • 3.1.2.1 Acute exposure of terrestrial plants and animals
        • 3.1.2.1.1 Terrestrial plants
        • 3.1.2.1.2 Terrestrial animals
      • 3.1.2.2 Chronic exposure of terrestrial plants and animals
        • 3.1.2.2.1 Terrestrial plants
        • 3.1.2.2.2 Terrestrial animals
      • 3.1.2.3 Discussion of uncertainty
  • 3.2 CEPA 1999 64(b): Environment upon which life depends
  • 3.3 CEPA 1999 64(c): Human health
    • 3.3.1 Estimated population exposure
    • 3.3.2 Hazard characterization
      • 3.3.2.1 Effects in humans
      • 3.3.2.2 Effects in experimental animals
    • 3.3.3 Dose-response analyses
      • 3.3.3.1 Inhalation
      • 3.3.3.2 Ingestion
    • 3.3.4 Human health risk characterization
    • 3.3.5 Uncertainties and degree of confidence in human health risk characterization
  • 3.4 Conclusions
  • 3.5 Considerations for follow-up (further action)
• 4.0 References
• Appendix A Search Strategies Employed for Identification of Relevant Data

List of Tables

• Table 1 - Physical and chemical properties of acrolein
• Table 2 - Sources and estimated releases of acrolein to air in Canada
• Table 3 - Summary of the hyperconservative environmental risk analysis
• Table 4 - Estimation of human exposure to acrolein
• Table 5 - Critical data and benchmark concentrations for acrolein

List of Figures

• Figure 1 - Chemical structure of acrolein
• Figure 2 - Benchmark concentrations for acrolein