Priority Substances List Assessment Report for N,N-Dimethylformamide

Environment Canada
Health Canada
2001
ISBN: 0-662-29191-3
Cat. No.: En40-215/54E

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(576K)

Canadian Environmental Protection Act, 1999

Table of Contents

• List of Acronyms and Abbreviations
• Synopsis
• 1.0 Introduction
• 2.0 Summary of Information Critical to Assessment of "Toxic" Under CEPA 1999
  • 2.1 Identity and physical/chemical properties
  • 2.2 Entry characterization
    • 2.2.1 Production, importation, exportation and use
    • 2.2.2 Releases of TMEs in Canada
      • 2.2.2.1 Natural sources
      • 2.2.2.2 Anthropogenic sources
  • 2.3 Exposure characterization
    • 2.3.1 Environmental fate
      • 2.3.1.1 Air
      • 2.3.1.2 Surface water and sediment
      • 2.3.1.3 Soil and groundwater
      • 2.3.1.4 Environmental distribution
    • 2.3.2 Environmental concentrations
      • 2.3.2.1 Ambient air
      • 2.3.2.2 Surface water and sediment
      • 2.3.2.3 Soil and groundwater
      • 2.3.2.4 Drinking water
      • 2.3.2.5 Food
      • 2.3.2.6 Consumer products
      • 2.3.2.7 Multimedia study
  • 2.4 Effects characterization
    • 2.4.1 Ecotoxicology
      • 2.4.1.1 Aquatic organisms
      • 2.4.1.2 Terrestrial organisms
    • 2.4.2 Abiotic atmospheric effects
    • 2.4.3 Experimental animals and in vitro
      • 2.4.3.1 Acute toxicity
      • 2.4.3.2 Irritation and sensitization
      • 2.4.3.3 Short-term and subchronic toxicity
        • 2.4.3.3.1 Inhalation exposure
        • 2.4.3.3.2 Oral exposure
      • 2.4.3.4 Chronic toxicity and carcinogenicity
        • 2.4.3.4.1 Inhalation exposure
        • 2.4.3.4.2 Oral exposure
      • 2.4.3.5 Genotoxicity
      • 2.4.3.6 Reproductive and developmental toxicity
        • 2.4.3.6.1 Reproductive toxicity
        • 2.4.3.6.2 Developmental toxicity
      • 2.4.3.7 Effects on neurological systems
      • 2.4.3.8 Immunotoxicity
      • 2.4.3.9 Toxicokinetics and metabolism
    • 2.4.4 Humans
      • 2.4.4.1 Cancer
      • 2.4.4.2 Effects on the liver
      • 2.4.4.3 Cardiac effects
      • 2.4.4.4 Genotoxicity
• 3.0 Assessment of "Toxic" under CEPA 1999
  • 3.1 CEPA 1999 64(a): Environment
    • 3.1.1 Terrestrial assessment endpoints
    • 3.1.2 Environmental risk characterization
      • 3.1.2.1 Terrestrial organisms
      • 3.1.2.2 Discussion of uncertainty
  • 3.2 CEPA 1999 64(b): Environment upon which life depends
  • 3.3 CEPA 1999 64(c): Human health
    • 3.3.1 Estimated population exposure
    • 3.3.2 Hazard characterization
      • 3.3.2.1 Effects on humans
      • 3.3.2.2 Effects on experimental animals
    • 3.3.3 Dose-response analysis
      • 3.3.3.1 Humans
      • 3.3.3.2 Experimental animals
    • 3.3.4 Human health risk characterization
    • 3.3.5 Uncertainties and degree of confidence in human health risk characterization
  • 3.4 Conclusion
  • 3.5 Considerations for follow-up (further action)
• 4.0 References

Appendices

• Appendix A Search Strategies Employed for Identification of Relevant Data

List of Tables

• Table 1 Physical and chemical properties of DMF
• Table 2 Toxicity of DMF to various organisms
• Table 3 Effect levels and benchmark concentrations for DMF, inhalation exposure
• Table 4 Effect levels and benchmark doses for DMF, oral exposure

List of Figures

• Figure 1 Chemical structure and identity of N,N-dimethylformamide (DMF)
• Figure 2 Biotransformation of DMF