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MATERIAL SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT NAME: Pasteurella spp. SYNONYM OR CROSS REFERENCE: Shipping fever, Pasteurella haemolytica, P. pneumotropica, P. aerogenes, P. sallinavum, P. multocida, Pasteurellosis CHARACTERISTICS: Non-spore forming, nonmotile, bipolar, gram negative coccobacilli; tendency towards pleomorphism, aerobic; 1.4 µm by 0.4 µm in size SECTION II - HEALTH HAZARD PATHOGENICITY: Localized infection such as cellulitis and abscess; onset less than 24 hours after animal bite or scratch; progress to osteomyelitis and arthritis in some individuals; less common forms chronic pulmonary infections, bacteremia, meningitis and septicemia; otitis media, hepatic cirrhosis and peritonitis are unusual manifestations EPIDEMIOLOGY: Worldwide; normal flora in many domestic animals (especially cats and dogs); rate of colonization of animals is higher during the cold seasons HOST RANGE: Domestic and wild animals; humans are accidental hosts INFECTIOUS DOSE: Not known MODE OF TRANSMISSION: Primarily by animal bite or scratch (especially from cats and dogs); inhalation of aerosols; wound contamination from infected tissues; mechanical transmission by fleas, flies and cockroaches INCUBATION PERIOD: Symptoms less than 24 hours after an animal bite COMMUNICABILITY: Communicable during period of active disease SECTION III - DISSEMINATION RESERVOIR: Cats, dogs; wild animals; birds (fowl) ZOONOSIS: Yes, by animal bite or scratch VECTORS: Fleas, flies, cockroaches, mosquitoes SECTION IV - VIABILITY DRUG SUSCEPTIBILITY: Sensitive to penicillin G and its derivatives (ampicillin, carbencillin, piperacillin), tetracycline, cephalothin, chloramphenicol DRUG RESISTANCE: First generation cephalosporins are ineffective SUSCEPTIBILITY TO DISINFECTANTS: Susceptible to most disinfectants; 1% sodium hypochlorite, 2% glutaraldehyde, 70% ethanol PHYSICAL INACTIVATION: Inactivated at 55° C for 15 minutes; unstable at low pH SURVIVAL OUTSIDE HOST: Blood remains infectious for 10 days under ambient conditions; infectious tissues survive up to 3 days in sunshine; survives in water at room temperature up to 5 days SECTION V - MEDICAL SURVEILLANCE: Monitor for symptoms FIRST AID/TREATMENT: Administer antibiotic therapy, surgery IMMUNIZATION: None available PROPHYLAXIS: None SECTION VI - LABORATORY HAZARDS LABORATORY-ACQUIRED INFECTIONS: Two case were reported associated with laboratory animals up to 1976 SOURCES/SPECIMENS: Lesion material (exudate and sputum); blood PRIMARY HAZARDS: Accidental parental inoculation; exposure to infectious aerosols SPECIAL HAZARDS: Naturally and experimentally infected animals pose a risk for laboratory and animal care personnel SECTION VII - RECOMMENDED PRECAUTIONS CONTAINMENT REQUIREMENTS: Biosafety level 2 practices, containment, equipment and facilities for activities involving clinical specimens and cultures of all species PROTECTIVE CLOTHING: Laboratory coat; gloves and gown with ties in the back tight wrist when working with infectious materials OTHER PRECAUTIONS: Heavy protective gloves and face shields to protect from infectious droplets or tissues fragments SECTION VIII - HANDLING INFORMATION SPILLS: Allow aerosols to settle; wearing protective clothing, gently cover spill with absorbent paper towel and apply 1% sodium hypochlorite starting at the perimeter and working towards centre; allow sufficient contact time (30 min) before clean up DISPOSAL: Decontaminate all wastes before disposal; steam sterilization, chemical disinfection, incineration STORAGE: In sealed containers that are appropriately labelled SECTION IX - MISCELLANEOUS INFORMATION Date prepared: March, 2001 Prepared by: Office of Laboratory Security, PHAC Although the information, opinions and recommendations contained in this Material Safety Data Sheet are compiled from sources believed to be reliable, we accept no responsibility for the accuracy, sufficiency, or reliability or for any loss or injury resulting from the use of the information. Newly discovered hazards are frequent and this information may not be completely up to date. Copyright © [Material Safety Data Sheets - Index]
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Last Updated: 2001-05-14 | ![]() |