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MATERIAL SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT NAME: Aspergillus spp. SYNONYM OR CROSS REFERENCE: Aspergillus fumigatus, A. niger, A. flavus, Aspergillosis, Farmer's lung CHARACTERISTICS: Rapidly growing mold with septate hyphae and conidia; differentiation on basis of conidiophores and conidia SECTION II - HEALTH HAZARD PATHOGENICITY: Variety of forms of infection depending on species involved, i.e. aspergilloma, aspergillosis pneumonia; aspergillosis is characterized by pulmonary infiltrates, eosinophilia and a rise in IgG; immunosuppressed individuals are prone to develop an acute pneumonia with multifocal infiltrates expanding to consolidation; dissemination to other organs (eg. cardiac valve) is common; most common cause of otomycosis; clinical manifestation and severity are largely determined by the general immunologic state of the patient EPIDEMIOLOGY: Worldwide; uncommon; hospital air and airducts associated with nosocomial outbreaks; high aflatoxin and other mycotoxins produced by A. flavus correlated to heptocellular cancer in Africa and Southeast Asia HOST RANGE: Humans INFECTIOUS DOSE: Not known MODE OF TRANSMISSION: Inhalation of airborne conidia INCUBATION PERIOD: Variable; few days to weeks COMMUNICABILITY: Not transmitted from person to person SECTION III - DISSEMINATION RESERVOIR: Widely distributed in nature; in soil, cereal grains, hay and other plant material or foodstuff ZOONOSIS: None VECTORS: None SECTION IV - VIABILITY DRUG SUSCEPTIBILITY: Susceptible to amphotericin B, itraconazole or voriconazole SUSCEPTIBILITY TO DISINFECTANTS: Susceptible to 1 % sodium hypochlorite,, 2% glutaraldehyde; susceptibility to 70% ethanol and phenolics questionable (0.4% chlorine for 2 min has been recommended for surface disinfection of food samples) PHYSICAL INACTIVATION: Inactivated by heat and irradiation SURVIVAL OUTSIDE HOST: Spores are very resistant; survive in soil and decaying matter for a long time SECTION V - MEDICAL SURVEILLANCE: Monitor for symptoms; confirm microscopically using potassium hydroxide. FIRST AID/TREATMENT: Administer amphotericin B; reduce immunosuppressive therapy where possible; surgical intervention in unusual "solid" lesion cases IMMUNIZATION: None available PROPHYLAXIS: None available SECTION VI - LABORATORY HAZARDS LABORATORY-ACQUIRED INFECTIONS: None reported to date (many non-laboratory occupationally-acquired infections have been reported). SOURCES/SPECIMENS: Sputum; soil and environmental samples may contain infectious conidia PRIMARY HAZARDS: Inhalation of conidia SPECIAL HAZARDS: None SECTION VII - RECOMMENDED PRECAUTIONS CONTAINMENT REQUIREMENTS: Biosafety level 2 practices and containment facilities for activities involving the fungus or infectious body fluids and tissues PROTECTIVE CLOTHING: Laboratory coat; gloves when skin contact with infectious materials is unavoidable OTHER PRECAUTIONS: None SECTION VIII - HANDLING INFORMATION SPILLS: Allow aerosols to settle; wearing protective clothing gently cover spill with absorbent paper towel and apply 1% sodium hypchlorite starting at the perimeter and working towards the centre; allow sufficient contact time (30 min) before clean up DISPOSAL: Decontaminate all wastes before disposal; steam sterilization, chemical disinfection, incineration STORAGE: In sealed containers that are appropriately labelled SECTION IX - MISCELLANEOUS INFORMATION Date prepared: November 1999 Prepared by: Office of Laboratory Security, PHAC Although the information, opinions and recommendations contained in this Material Safety Data Sheet are compiled from sources believed to be reliable, we accept no responsibility for the accuracy, sufficiency, or reliability or for any loss or injury resulting from the use of the information. Newly discovered hazards are frequent and this information may not be completely up to date. Copyright © [Material Safety Data Sheets - Index]
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Last Updated: 2001-01-23 | ![]() |