![]() |
|||||||||||||||||
![]() |
|||||||||||||||||
![]() ![]() ![]() |
![]() |
|
|||||||||||||||
![]() |
![]() |
MATERIAL SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT NAME: Rhinovirus SYNONYM OR CROSS REFERENCE: Acute viral rhinitis, acute coryza, common cold virus CHARACTERISTICS: Picornaviridae; icosahedral, about 27 nm diameter, ss positive sense RNA, non-lipid enveloped capsid SECTION II - HEALTH HAZARD PATHOGENICITY: Most frequent cause of the common cold responsible for 30-50% of cases; acute infection of the upper respiratory tract; characterized by coryza, sneezing, lacrimation, irritated nasopharynx, headache, sore throat, chilliness and malaise lasting 2-7 days; little or no fever; can be accompanied by laryngitis, tracheitis and bronchitis; secondary bacterial infection may produce acute otis media, sinusitis or pneumonitis EPIDEMIOLOGY: Worldwide; occurs mostly in the early fall and winter; over 100 recognized serotypes; incidence highest in children < 5 years HOST RANGE: Humans INFECTIOUS DOSE: Ranges from 0.032 to 0.4 TCID50 when given as nasal spray MODE OF TRANSMISSION: Direct contact or inhalation of infectious airborne droplets; indirect spread by contaminated hands and freshly soiled articles INCUBATION PERIOD: From 2-4 days COMMUNICABILITY: Nasal discharges taken 24 hours before and 5 days after onset have been shown to be infectious SECTION III - DISSEMINATION RESERVOIR: Humans ZOONOSIS: None VECTORS: None SECTION IV - VIABILITY DRUG SUSCEPTIBILITY: No specific antivirals although sensitive to alpha-2 interferon SUSCEPTIBILITY TO DISINFECTANTS: Susceptible to l.0% sodium hypochlorite, tincture of iodine, phenol-alcohol disinfectant, 2% glutaraldehyde; resistant to organic solvents, ethanol PHYSICAL INACTIVATION: Inactivates at pH < 3.6 SURVIVAL OUTSIDE HOST: Relatively stable at 24-35° C; survives for days on environmental surfaces; survives on the human skin up to 3 hours; survival in aerosols enhanced by low temperature and high relative humidity SECTION V - MEDICAL SURVEILLANCE: Identification by tissue culture FIRST AID/TREATMENT: Rest, hydration, nasal decongestant and saline gargles IMMUNIZATION: None PROPHYLAXIS: Antiviral agents have proven effective in vitro, but with little effect in clinical trials SECTION VI - LABORATORY HAZARDS LABORATORY-ACQUIRED INFECTIONS: None reported although probably quite common SOURCES/SPECIMENS: Nose and throat secretions PRIMARY HAZARDS: Droplet exposure of mucous membranes; indirect via hands SPECIAL HAZARDS: None SECTION VII - RECOMMENDED PRECAUTIONS CONTAINMENT REQUIREMENTS: Biosafety level 2 practices and containment for activities utilizing infectious body fluids, tissues and cultures PROTECTIVE CLOTHING: Laboratory coat; gloves when skin contact with infectious materials is unavoidable OTHER PRECAUTIONS: None SECTION VIII - HANDLING INFORMATION SPILLS: Allow aerosols to settle; wearing protective clothing gently cover spill with absorbent paper towel and apply 1% sodium hypochlorite starting at perimeter and working towards the center; allow sufficient contact time (30 min) before clean up DISPOSAL: Decontaminate all wastes before disposal; steam sterilization, chemical disinfection, incineration STORAGE: In sealed containers that are appropriately labelled SECTION IX - MISCELLANEOUS INFORMATION Date prepared: February, 2001 Prepared by: Office of Laboratory Security, PHAC Although the information, opinions and recommendations contained in this Material Safety Data Sheet are compiled from sources believed to be reliable, we accept no responsibility for the accuracy, sufficiency, or reliability or for any loss or injury resulting from the use of the information. Newly discovered hazards are frequent and this information may not be completely up to date. Copyright © [Material Safety Data Sheets - Index]
|
![]() |
|||
![]() |
Last Updated: 2001-09-27 | ![]() |