![]() |
|||||||||||||||||
![]() |
|||||||||||||||||
![]() ![]() ![]() |
![]() |
|
|||||||||||||||
![]() |
![]() |
MATERIAL SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT NAME: Serratia spp. SYNONYM OR CROSS REFERENCE: S. marcescens, S. liquefaciens, S. odorifera, S. rubidaea, S. ficaria, S. fonticola, S. marinorubra, S. plymuthica CHARACTERISTICS: Family Enterobacteriaceae, gram negative bacilli, non-spore forming, facultatively anaerobic, motile with peritrichous flagella, sometimes capsulated, some species produce pink or red pigments SECTION II - HEALTH HAZARD PATHOGENICITY: Opportunistic infections of the endocardium, eyes, blood, wounds, urinary and respiratory tracts; infections are often severe or fatal; Notorious nosocomial pathogens, particularly S. marcescens which is responsible for 4% of hospital acquired pneumonias; Serious reactions have occurred to blood transfusions contaminated with S. liquefaciens; causes ocular complications associated with contact lenses EPIDEMIOLOGY: Worldwide; isolated with increasing frequency probably due to nosocomial spread; important nosocomial infection causing outbreaks in nurseries, intensive-care units and renal dialysis units HOST RANGE: Humans INFECTIOUS DOSE: Not known MODE OF TRANSMISSION: Direct contact of the mucous membranes to infectious agents, transferred by contaminated persons, medical devices, intravenous fluids or other solutions; contact with contaminated respiratory therapy devices has resulted in numerous nosocomial infections INCUBATION PERIOD: Not clearly identified COMMUNICABILITY: Not directly transmitted from person-to-person SECTION III - DISSEMINATION RESERVOIR: Ubiquitous, occur in plants, soil and water ZOONOSIS: None VECTORS: None SECTION IV - VIABILITY DRUG SUSCEPTIBILITY: Variable susceptibility to antimicrobial drugs; sensitive to aminoglycosides (amikacin); intrinsically resistant to penicillin G, colistin and cephalothin; multi-drug resistant strains are common including resistance to imipenem; many strains are initially susceptible to cephalosporins and aminocyclinols, but develop resistance during therapy SUSCEPTIBILITY TO DISINFECTANTS: Susceptible to many disinfectants - 1% sodium hypochlorite, 70% ethanol, 2% glutaraldehyde, iodines, phenolics, formaldehyde; Strains have been recovered with resistance to quaternary ammonium compounds and chlorhexidine; nosocomial infections have been associated with non-medicated hand soap PHYSICAL INACTIVATION: Sensitive to moist heat (121° C for at least 15 min) and dry heat (160-170° C for at least 1 hour) SURVIVAL OUTSIDE HOST: dust - up to 35 days; glass - 4 to 9 days; beetle - 30 to 35 days; sheet metal - 5 days; paper - 5 days; skin - 30 min; silk threads - up to 72 days SECTION V - MEDICAL SURVEILLANCE: Careful evaluation of clinical course FIRST AID/TREATMENT: Determine antibiotic susceptibility followed by antibiotic therapy; surgical drainage of wounds or abscesses IMMUNIZATION: None PROPHYLAXIS: Not usually administered SECTION VI - LABORATORY HAZARDS LABORATORY-ACQUIRED INFECTIONS: At least 5 reported laboratory infections with S. marcescens (formerly used as a marker in aerobiology) SOURCES/SPECIMENS: Feces, wound exudates, respiratory specimens, blood, urine PRIMARY HAZARDS: Accidental parenteral inoculation; direct contact of mucous membranes with infectious materials; inhalation of infectious droplets; ingestion SPECIAL HAZARDS: None SECTION VII - RECOMMENDED PRECAUTIONS CONTAINMENT REQUIREMENTS: Biosafety level 2 practices, containment equipment and facilities are recommended for activities involving infectious clinical materials and cultures of S. marcescens and S. liquifaciens PROTECTIVE CLOTHING: Laboratory coat; gloves when direct contact with infectious materials is unavoidable OTHER PRECAUTIONS: None SECTION VIII - HANDLING INFORMATION SPILLS: Allow aerosols to settle; wearing protective clothing, gently cover spill with paper towel and apply 1% sodium hypochlorite; starting at perimeter and working towards the centre; allow sufficient contact time (30 min) before clean up DISPOSAL: Decontaminate before disposal; steam sterilization, chemical disinfection, incineration STORAGE: In sealed containers that are appropriately labelled SECTION IX - MISCELLANEOUS INFORMATION Date prepared: March, 2001 Prepared by: Office of Laboratory Security, PHAC Although the information, opinions and recommendations contained in this Material Safety Data Sheet are compiled from sources believed to be reliable, we accept no responsibility for the accuracy, sufficiency, or reliability or for any loss or injury resulting from the use of the information. Newly discovered hazards are frequent and this information may not be completely up to date. Copyright © [Material Safety Data Sheets - Index]
|
![]() |
|||
![]() |
Last Updated: 2001-04-23 | ![]() |