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MATERIAL SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT NAME: Sindbis virus SYNONYM OR CROSS REFERENCE: Epidemic polyarthritis and rash, Sindbis virus disease, SIN, ockelbo virus CHARACTERISTICS: Family Togaviridae, genus Alphavirus; enveloped virions icosahedral with 40-70 nm diameter, single-stranded, positive-sense RNA genome SECTION II - HEALTH HAZARD PATHOGENICITY: Self-limiting febrile viral disease. Sudden onset of fever, rash, arthralgia or arthritis, lassitude, headache and myalgia; rash may precede or follow joint manifestations by 1-2 days ;exanthem on trunk progressing to face, legs, palm, soles and lasts on average 10 days; signs of jaundice and myocardial damage are reported but rare; often no recognized clinical disease manifestations EPIDEMIOLOGY: Common in Africa, Asia, Australia, Middle East, Eastern Europe, Scandinavia and the Commonwealth of Independent States HOST RANGE: Humans, mammals, birds INFECTIOUS DOSE: Not known MODE OF TRANSMISSION: By the bite of an infectious mosquito INCUBATION PERIOD: less than 7 days COMMUNICABILITY: No evidence of person-to-person transmission documented SECTION III - DISSEMINATION RESERVOIR: Birds ZOONOSIS: Yes - by the bite of an infected mosquito VECTORS: Mosquitoes (Anopheles, Aedes, Culex and Culista spp.) SECTION IV - VIABILITY DRUG SUSCEPTIBILITY: No specific antiviral available to date SUSCEPTIBILITY TO DISINFECTANTS: Susceptible to 70% ethanol, 1% sodium hypochlorite, 2% glutaraldehyde, organic solvents/detergents PHYSICAL INACTIVATION: Sensitive to heat, UV and gamma irradiation and freezing SURVIVAL OUTSIDE HOST: Survives in blood up to 2 days at room temperature SECTION V - MEDICAL SURVEILLANCE: Monitor for symptoms; confirm by serological analysis FIRST AID/TREATMENT: Mainly supportive therapy IMMUNIZATION: None available PROPHYLAXIS: None available SECTION VI - LABORATORY HAZARDS LABORATORY-ACQUIRED INFECTIONS: None reported to date SOURCES/SPECIMENS: Blood specimens PRIMARY HAZARDS: Accidental parenteral inoculation; droplet exposure of the mucous membranes SPECIAL HAZARDS: None SECTION VII - RECOMMENDED PRECAUTIONS CONTAINMENT REQUIREMENTS: Biosafety level 2 practices and containment facilities for all activities involving the virus or infectious or potentially infectious body fluids or tissues PROTECTIVE CLOTHING: Laboratory coat; gloves when skin contact with infectious materials is unavoidable OTHER PRECAUTIONS: None SECTION VIII - HANDLING INFORMATION SPILLS: Allow aerosols to settle; wearing protective clothing, gently cover the spill with absorbent paper towel and apply 1% sodium hypochlorite, starting at the perimeter and working towards the center; allow sufficient contact time (30 min) before clean up DISPOSAL: Decontaminate all wastes before disposal; steam sterilization, incineration, chemical disinfection STORAGE: In sealed containers that are appropriately labelled SECTION IX - MISCELLANEOUS INFORMATION Date prepared: March, 2001 Prepared by: Office of Laboratory Security, PHAC Although the information, opinions and recommendations contained in this Material Safety Data Sheet are compiled from sources believed to be reliable, we accept no responsibility for the accuracy, sufficiency, or reliability or for any loss or injury resulting from the use of the information. Newly discovered hazards are frequent and this information may not be completely up to date. Copyright © [Material Safety Data Sheets - Index]
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Last Updated: 2001-04-23 | ![]() |