![]() |
|||||||||||||||||
![]() |
|||||||||||||||||
![]() ![]() ![]() |
![]() |
|
|||||||||||||||
![]() |
![]() |
MATERIAL SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT NAME: Treponema pallidum SYNONYM OR CROSS REFERENCE: Syphilis, Lues CHARACTERISTICS: Spirochete, helically coiled, corkscrew-shaped cell, 6-15 µm long 0.1-0.2 µm wide; outer membrane, axial membrane (membrane-covered flagella), cytoplasmic tubules, an inner cytoplasmic membrane SECTION II - HEALTH HAZARD PATHOGENICITY: Diverse clinical manifestations; initial genital tract lesion followed by disseminated lesions and cardiovascular and neurologic problems; CNS disease manifested as acute syphilitic meningitis; infection during pregnancy results in fetal death and numerous birth defects; infections are usually chronic; death or serious disability is rare EPIDEMIOLOGY: Worldwide; primarily involving young people between 20-35 years HOST RANGE: Humans INFECTIOUS DOSE: Not known MODE OF TRANSMISSION: By direct contact with skin lesions, mucous membranes, body fluids and secretions (semen, vaginal discharge, saliva, blood) of infected persons during sexual contact; rarely by kissing, blood transfusion; congenital transmission is possible INCUBATION PERIOD: From 10 days to 3 months; usually 3 weeks COMMUNICABILITY: During the primary and secondary stages of the disease and during the recurrent lesions; inapparent lesions may be potentially infectious SECTION III - DISSEMINATION RESERVOIR: Humans ZOONOSIS: None VECTORS: None SECTION IV - VIABILITY DRUG SUSCEPTIBILITY: Sensitive to penicillin G, doxycycline, tetracycline SUSCEPTIBILITY TO DISINFECTANTS: Susceptible to 70% ethanol, 1% sodium hypochlorite, 2% glutaraldehyde PHYSICAL INACTIVATION: Sensitive to heating at 65° C for 30 minutes SURVIVAL OUTSIDE HOST: Survives up 24 hours in blood at room temperature SECTION V - MEDICAL SURVEILLANCE: Monitor for symptoms; confirm by serological analysis and microscopic demonstration FIRST AID/TREATMENT: Administer appropriate drug therapy IMMUNIZATION: None available PROPHYLAXIS: None available SECTION VI - LABORATORY HAZARDS LABORATORY-ACQUIRED INFECTIONS: Fifteen cases were reported up to 1980 SOURCES/SPECIMENS: Semen, vaginal secretions, lesion material PRIMARY HAZARDS: Accidental parenteral inoculation, droplet exposure on mucous membrane SPECIAL HAZARDS: None SECTION VII - RECOMMENDED PRECAUTIONS CONTAINMENT REQUIREMENTS: Biosafety level 2 practices and containment equipment for all activities involving the bacteria and potentially infectious tissues or fluids PROTECTIVE CLOTHING: Laboratory coat; gloves when skin contact with infectious materials is unavoidable OTHER PRECAUTIONS: Pregnant women should avoid contact with infectious material SECTION VIII - HANDLING INFORMATION SPILLS: Allow aerosols to settle; wearing protective clothing, gently cover the spill with absorbent paper and apply 1% sodium hypochlorite, starting at the perimeter and working towards the center; allow sufficient contact time (30 min) before clean up DISPOSAL: Decontaminate all wastes before disposal; steam sterilization, chemical disinfection, incineration STORAGE: In sealed containers that are appropriately labelled SECTION IX - MISCELLANEOUS INFORMATION Date prepared: May, 2001 Prepared by: Office of Laboratory Security, PHAC Although the information, opinions and recommendations contained in this Material Safety Data Sheet are compiled from sources believed to be reliable, we accept no responsibility for the accuracy, sufficiency, or reliability or for any loss or injury resulting from the use of the information. Newly discovered hazards are frequent and this information may not be completely up to date. Copyright © [Material Safety Data Sheets - Index]
|
![]() |
|||
![]() |
Last Updated: 2001-09-25 | ![]() |