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MATERIAL SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT NAME: Bartonella bacilliformis SYNONYM OR CROSS REFERENCE: Bartonellosis, Oroya fever, Verruga peruana, Carrion's disease CHARACTERISTICS: Small, gram-negative, motile rods with polar flagella SECTION II - HEALTH HAZARD PATHOGENICITY: Characterized by two different clinical forms: a febrile anemia (Oroya fever) manifested by irregular fever, severe anemia, generalized lymphadenopathy and delirium; a dermal eruption (Verruga peruana) of small, hemangioma-like nodules with muscle and joint pain, and may be preceded by Oroya fever; fatality rate ranges from 10- 90% for untreated Oroya fever EPIDEMIOLOGY: Limited to mountain valleys of Peru, Ecuador, and Southwest Columbia where the sandfly vector is present HOST RANGE: Humans INFECTIOUS DOSE: Not known MODE OF TRANSMISSION: By the bite of sandflies (Lutzomyia); blood transfusion INCUBATION PERIOD: Usually 16 to 22 days, occasionally 3 to 4 months COMMUNICABILITY: Person to person transmission not documented; patient's blood remains infectious for sandfly months after illness SECTION III - DISSEMINATION RESERVOIR: Humans ZOONOSIS: None VECTORS: Sandfly (Lutzomyia) SECTION IV - VIABILITY DRUG SUSCEPTIBILITY: Susceptible to penicillin, streptomycin, chloramphenicol, tetracycline DRUG RESISTANCE: Nalidixic acid; in vitro resistance to penicillin and ampicillin, tetracycline and vancomycin has been noted SUSCEPTIBILITY TO DISINFECTANTS: Susceptible to common disinfectants: 70% ethanol, 1% sodium hypochlorite, 2% formaldehyde PHYSICAL INACTIVATION: Sensitive to heating SURVIVAL OUTSIDE HOST: Survives in tap water at room temperature for up to 7 days SECTION V - MEDICAL SURVEILLANCE: Monitor for symptoms; demonstration of organism in blood or skin lesions FIRST AID/TREATMENT: Antibiotic therapy IMMUNIZATION: None available PROPHYLAXIS: None available SECTION VI - LABORATORY HAZARDS LABORATORY-ACQUIRED INFECTIONS: One case reported up to 1988 SOURCES/SPECIMENS: Blood, skin lesion PRIMARY HAZARDS: Accidental parenteral inoculation; contact with infected laboratory sandflies SPECIAL HAZARDS: None SECTION VII - RECOMMENDED PRECAUTIONS CONTAINMENT REQUIREMENTS: Biosafety level 2 practices and containment facilities for activities involving known or potentially infectious materials PROTECTIVE CLOTHING: Laboratory coat and gloves when working with infectious materials OTHER PRECAUTIONS: Avoid accidental inoculation and follow general needle safety practices SECTION VIII - HANDLING INFORMATION SPILLS: Allow aerosols to settle; wearing protective clothing, gently cover spill with absorbent paper towel and apply 1% sodium hypochlorite starting at the perimeter and working towards the centre; allow sufficient contact time (30 min) before clean up DISPOSAL: Decontaminate all wastes before disposal; steam sterilization, chemical disinfection, incineration STORAGE: In sealed containers that are appropriately labelled SECTION IX - MISCELLANEOUS INFORMATION Date prepared: November 1999 Prepared by: Office of Laboratory Security, PHAC Although the information, opinions and recommendations contained in this Material Safety Data Sheet are compiled from sources believed to be reliable, we accept no responsibility for the accuracy, sufficiency, or reliability or for any loss or injury resulting from the use of the information. Newly discovered hazards are frequent and this information may not be completely up to date. Copyright © [Material Safety Data Sheets - Index]
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Last Updated: 2001-01-23 | ![]() |