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MATERIAL SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT NAME: Bordetella bronchiseptica SYNONYM OR CROSS REFERENCE: Bacillus bronchiseptica, Brucella bronchiseptica, Hemophilus bronchiseptica, Kennel cough (in dogs), atrophic rhinitis (in swine) CHARACTERISTICS: Gram-negative coccobacilli, aerobic, motile, grows sparsely on nutrient agar SECTION II - HEALTH HAZARD PATHOGENICITY: Rarely found in humans, however can cause pertussis-like symptoms in immunocompetent hosts; in immunocompromised hosts, illness can range in severity from mild respiratory symptoms to pneumonia; carrier state may exist EPIDEMIOLOGY: Worldwide HOST RANGE: Humans, rodents, swine, dogs, cats and non-human primates INFECTIOUS DOSE: Unknown MODE OF TRANSMISSION: Direct contact with infectious droplets and aerosols INCUBATION PERIOD: Unknown COMMUNICABILITY: Communicable from person to person through coughing and the generation of infectious droplets SECTION III - DISSEMINATION RESERVOIR: Infected persons, rodents, swine, dogs and lower primates ZOONOSIS: Yes, can be transmitted from infected animals to humans by infected aerosols, probably droplets VECTORS: None SECTION IV - VIABILITY DRUG SUSCEPTIBILITY: Susceptible in vitro to gentamicin, tobramycin, amikacin, some penicillins, some cephalosporins, chloramphenicol and tetracycline DRUG RESISTANCE: Resistant to erythromycin SUSCEPTIBILITY TO DISINFECTANTS: Sensitive to many disinfectants - 1% sodium hypochlorite, 70% ethanol, glutaraldehyde, formaldehyde, iodines, phenolics PHYSICAL INACTIVATION: Susceptible to moist heat (121°C for at least 1 hour) and dry heat 160-170°C for at least 1 hour SURVIVAL OUTSIDE HOST: Does not survive well outside of host; sensitive to drying and cold temperatures; has been shown to survive ~24 weeks in phosphate-buffered saline and lakewater SECTION V - MEDICAL SURVEILLANCE: Monitor for symptoms FIRST AID/TREATMENT: Antibiotic treatment may be considered IMMUNIZATION: None available for humans PROPHYLAXIS: None SECTION VI - LABORATORY HAZARDS LABORATORY-ACQUIRED INFECTIONS: Low risk of laboratory-acquired infection SOURCES/SPECIMENS: Respiratory specimens PRIMARY HAZARDS: Direct contact of mucous membranes with infectious aerosols and droplets SPECIAL HAZARDS: B. bronchiseptica is a frequent cause of bronchopneumonia in animals; infected animals may generate infectious aerosols SECTION VII - RECOMMENDED PRECAUTIONS CONTAINMENT REQUIREMENTS: Biosafety level 2 practices, containment equipment and facilities for work with known or potentially infectious specimens and cultures; work likely to generate aerosols should be carried out in a biosafety cabinet PROTECTIVE CLOTHING: Laboratory coat; gloves when direct contact with infectious materials is unavoidable; gloves and gown (tight wrists and ties in back) should be worn for procedures conducted in the biosafety cabinet OTHER PRECAUTIONS: Caution should be exercised when working with infected animals SECTION VIII - HANDLING INFORMATION SPILLS: Allow aerosols to settle; wearing protective clothing, gently cover spill with paper towels and apply 1% sodium hypochlorite, starting at perimeter and working towards the centre; allow sufficient contact time (30 min) before clean up DISPOSAL: Decontaminate before disposal; steam sterilization, chemical disinfection, incineration STORAGE: In sealed containers that are labelled appropriately SECTION IX - MISCELLANEOUS INFORMATION Date prepared: November 1999 Prepared by: Office of Laboratory Security, PHAC Although the information, opinions and recommendations contained in this Material Safety Data Sheet are compiled from sources believed to be reliable, we accept no responsibility for the accuracy, sufficiency, or reliability or for any loss or injury resulting from the use of the information. Newly discovered hazards are frequent and this information may not be completely up to date. Copyright © [Material Safety Data Sheets - Index]
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Last Updated: 2001-01-23 | ![]() |