![]() |
|||||||||||||||||
![]() |
|||||||||||||||||
![]() ![]() ![]() |
![]() |
|
|||||||||||||||
![]() |
![]() |
MATERIAL SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT NAME: Brugia spp. SYNONYM OR CROSS REFERENCE: Brugia malayi, B. timori, filariasis, Brugian filariasis, Malayan filariasis, Timorean filariasis CHARACTERISTICS: Filarial parasite (nematode), sheathed microfilariae are 200-300 µm in length and 4-7 µm in width SECTION II - HEALTH HAZARD PATHOGENICITY: Characterized by recurring lymphadenitis and lymphangitis accompanied with fever; lymphatic abscesses and consequent scarring are common features; lymphedema appears and progresses to elephantiasis usually confined to the distal extremities in a small proportion of cases EPIDEMIOLOGY: B. malayi endemic in Southeast Asia, rural southwest India, Sri Lanka, China and South Korea: B. timori found in Timor, Flores, Alor, Roti, and South East Indonesia HOST RANGE: Humans, cats, civet, nonhuman primates and mosquitoes INFECTIOUS DOSE: Not known MODE OF TRANSMISSION: By the bite of an infected mosquito; B. malayi transmitted by various species of Mansonia, Anopheles and Aedes; B. timori transmitted by Anopheles barbirostris INCUBATION PERIOD: Variable; allergic manifestations may appear as early as a month after infection; microfilariae may not appear in blood until 3-6 months after infection. COMMUNICABILITY: Not directly transmitted from person-to-person; microfilariae may persist for 5 years or longer after initial infection; mosquito becomes infective about l2-l4 days after an infective blood meal SECTION III - DISSEMINATION RESERVOIR: Humans with microfilariae in the blood (B. malayi and B. timori); cats, civets, nonhuman primates and mosquitoes (B. malayi) ZOONOSIS: Yes - infection acquired by a mosquito bite VECTORS: Yes - mosquitoes (Mansonia, Anopheles and Aedes spp.) SECTION IV - VIABILITY DRUG SUSCEPTIBILITY: Sensitive to diethylcarbamazine (DEC) SUSCEPTIBILITY TO DISINFECTANTS: Susceptible to 1% sodium hypochlorite, 2% glutaraldehyde PHYSICAL INACTIVATION: Sensitive to drying SURVIVAL OUTSIDE HOST: Sensitive to freezing SECTION V - MEDICAL SURVEILLANCE: Monitor for symptoms; confirm by microscopic demonstration of microfilariae in blood FIRST AID/TREATMENT: Administer appropriate drug therapy IMMUNIZATION: None available PROPHYLAXIS: Daily dose of diethylcarbamazine (DEC) SECTION VI - LABORATORY HAZARDS LABORATORY-ACQUIRED INFECTIONS: None reported to date SOURCES/SPECIMENS: Blood specimens PRIMARY HAZARDS: Ingestion; accidental parenteral inoculation; droplet exposure of mucous membrane SPECIAL HAZARDS: None SECTION VII - RECOMMENDED PRECAUTIONS CONTAINMENT REQUIREMENTS: Biosafety level 2 practices and containment equipment for all activities involving the parasite, infectious or potentially infectious body fluids or tissues PROTECTIVE CLOTHING: Laboratory coat; gloves when skin contact with infectious materials is unavoidable OTHER PRECAUTIONS: None SECTION VIII - HANDLING INFORMATION SPILLS: Allow aerosols to settle; wearing protective clothing, gently cover the spill with absorbent paper towel and apply 1% sodium hypochlorite, starting at the perimeter and working towards the centre; allow sufficient contact time (30 min) before clean up DISPOSAL: Decontaminate all wastes before disposal: steam sterilization, chemical disinfection, incineration STORAGE: In sealed containers that are appropriately labelled SECTION IX - MISCELLANEOUS INFORMATION Date prepared: November 1999 Prepared by: Office of Laboratory Security, PHAC Although the information, opinions and recommendations contained in this Material Safety Data Sheet are compiled from sources believed to be reliable, we accept no responsibility for the accuracy, sufficiency, or reliability or for any loss or injury resulting from the use of the information. Newly discovered hazards are frequent and this information may not be completely up to date. Copyright © [Material Safety Data Sheets - Index]
|
![]() |
|||
![]() |
Last Updated: 2001-01-23 | ![]() |