MATERIAL SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT NAME: Actinomyces spp. SYNONYM OR CROSS REFERENCE: A. israelii, A. naeslundii, A. meyeri, A. propionicus was Arachnia propionica now called (Propionibacterium propionicum), A. odontolyticus CHARACTERISTICS: Gram positive rods that grow as filaments, branching rods and diphtheroid rods; non-spore-forming; contains well developed pili; microaerophilic to anaerobic; contains sulfur granules SECTION II - HEALTH HAZARD PATHOGENICITY: Opportunistic pathogen. Chronic bacterial disease localized in jaw, thorax, or abdomen. Characterized by persistent swelling, suppuration and formation of abscesses or granulomas; major types are cervicofacial, thoracic and abdominal; hematogenous spread to other organs, although rare, is possible. May also be involved in pelvic inflammatory disease associated with intrauterine contraceptive devices. A. naeslundii is believed to be involved in dental caries and periodontal disease EPIDEMIOLOGY: Worldwide; normal inhabitant of the mouth and found in saliva, on the tongue, gingival crevices; disease results after trauma or immune suppression; infrequent disease, sporadic, 15-35 years of age; 2 to 1 male/female ratio HOST RANGE: Humans, and other Actinomyces species in cattle, horses and other animals INFECTIOUS DOSE: Not known MODE OF TRANSMISSION: Person-to-person by contact of mouth, aerosols, fomites INCUBATION PERIOD: Irregular, may be days or months after precipitating trauma of oral tissues COMMUNICABILITY: Unknown SECTION III - DISSEMINATION RESERVOIR: Humans; the organisms grow as saprophytes in normal oral cavity ZOONOSIS: None VECTORS: None SECTION IV - VIABILITY DRUG SUSCEPTIBILITY: Susceptible to penicillin, cephalosporin, tetracycline, chloramphenicol, carbenicillin SUSCEPTIBILITY TO DISINFECTANTS: Susceptible to many disinfectants: 70% ethanol, 1% sodium hypochlorite, 2% glutaraldehyde PHYSICAL INACTIVATION: Sensitive to heat SURVIVAL OUTSIDE HOST: Survived on glass surface for 49 days and in tap water for up to 3 days SECTION V - MEDICAL SURVEILLANCE: Monitor for symptoms and demonstration of organism in tissue or pus FIRST AID/TREATMENT: Surgical drainage of abscesses, antibiotic therapy IMMUNIZATION: None available PROPHYLAXIS: None available SECTION VI - LABORATORY HAZARDS LABORATORY-ACQUIRED INFECTIONS: One case was reported that was due to the inhalation of infectious aerosols SOURCES/SPECIMENS: Saliva, tissue, pus PRIMARY HAZARDS: Accidental parenteral inoculation, inhalation of infectious aerosols SPECIAL HAZARDS: None SECTION VII - RECOMMENDED PRECAUTIONS CONTAINMENT REQUIREMENTS: Biosafety level 2 practices and containment facilities for all activities involving the bacteria or any infectious fluid or tissue PROTECTIVE CLOTHING: Laboratory coat; gloves when skin contact with infectious material is unavoidable OTHER PRECAUTIONS: None SECTION VIII - HANDLING INFORMATION SPILLS: Allow aerosols to settle; wearing protective clothing gently cover spill with absorbent paper towel and apply 1% sodium hypochlorite starting at the perimeter and working towards the centre; allow sufficient contact time (30 min) before clean up DISPOSAL: Decontaminate all wastes before disposal; steam sterilization, chemical disinfection, incineration STORAGE: In sealed containers that are appropriately labelled SECTION IX - MISCELLANEOUS INFORMATION Date prepared: November 1999 Prepared by: Office of Laboratory Security, PHAC Although the information, opinions and recommendations contained in this Material Safety Data Sheet are compiled from sources believed to be reliable, we accept no responsibility for the accuracy, sufficiency, or reliability or for any loss or injury resulting from the use of the information. Newly discovered hazards are frequent and this information may not be completely up to date. Copyright © [Material Safety Data Sheets - Index]
|
Last Updated: 2001-01-23 |