MATERIAL SAFETY DATA SHEET - INFECTIOUS SUBSTANCES

SECTION I - INFECTIOUS AGENT

NAME: Adenovirus types 40 and 41

SYNONYM OR CROSS REFERENCE: Adv 40, Adv 41, Mastadenovirus h40, Mastadenovirus h41, subgenus F, enteric adenovirus

CHARACTERISTICS: Adenoviridae; double-stranded, linear DNA genome, 70-90 nm diameter, non-enveloped, icosahedral

SECTION II - HEALTH HAZARD

PATHOGENICITY: Local replication in intestine causes a mild disease with clinical symptoms of nausea, vomiting, diarrhea, malaise; virus show restricted replication; tissues of the eye and respiratory tract; asymptomatic infection common (virus in faeces of healthy individuals)

EPIDEMIOLOGY: Worldwide; in outbreaks and sporadic cases; cause severe cases in infants and young children; infections occur throughout the year with no clear peaks

HOST RANGE: Humans; experimentally infected rabbits, pigs and calves

INFECTIOUS DOSE: Unknown

MODE OF TRANSMISSION: presumably person-to-person by the fecal-oral route; respiratory route

INCUBATION PERIOD: 3 to 10 days

COMMUNICABILITY: During acute stage of disease; healthy adults may be carriers

SECTION III - DISSEMINATION

RESERVOIR: Humans

ZOONOSIS: None

VECTORS: None

SECTION IV - VIABILITY

DRUG SUSCEPTIBILITY: Not applicable

SUSCEPTIBILITY TO DISINFECTANTS: Susceptible to 1% sodium hypochlorite, glutaraldehyde, formaldehyde; some non-lipid viruses are only moderately resistant to disinfectants, i.e. 70% ethanol

PHYSICAL INACTIVATION: Susceptible to heat (56°C for at least 30 min); infectivity sensitive to ionizing radiation; stable to lipid solvents

SURVIVAL OUTSIDE HOST: Stable for some time in the environment

SECTION V - MEDICAL

SURVEILLANCE: Watch for symptoms of respiratory or gastrointestinal illness

FIRST AID/TREATMENT: Electrolyte and fluid replacement in severe cases

IMMUNIZATION: None available

PROPHYLAXIS: Not available

SECTION VI - LABORATORY HAZARDS

LABORATORY-ACQUIRED INFECTIONS: Low potential infection risk to laboratory personnel; 10 reported cases up to 1974

SOURCES/SPECIMENS: Nasopharageal secretions, eye exudates, fecal specimens, urine specimens

PRIMARY HAZARDS: Ingestion; accidental parenteral inoculation; droplet exposure of the mucous membranes of the eyes, nose, or mouth; inhalation of concentrated aerosolized material

SPECIAL HAZARDS: None

SECTION VII - RECOMMENDED PRECAUTIONS

CONTAINMENT REQUIREMENTS: Biosafety level 2 practices, containment equipment and facilities for activities utilizing known or potentially infectious clinical materials or cultures

PROTECTIVE CLOTHING: Laboratory coat; gloves when direct contact with infectious materials is unavoidable

OTHER PRECAUTIONS: Procedures that are likely to generate aerosols should be conducted in a biosafety cabinet

SECTION VIII - HANDLING INFORMATION

SPILLS: Allow aerosols to settle; wearing protective clothing, gently cover spill with an absorbent material (paper towel) and then apply 1% sodium hypochlorite, starting at the perimeter and working towards the centre; allow sufficient contact time (30 min) before clean up

DISPOSAL: Decontaminate before disposal - steam sterilization, incineration, chemical disinfection

STORAGE: In sealed containers with appropriate labelling

SECTION IX - MISCELLANEOUS INFORMATION

Date prepared: November 1999

Prepared by: Office of Laboratory Security, PHAC

Although the information, opinions and recommendations contained in this Material Safety Data Sheet are compiled from sources believed to be reliable, we accept no responsibility for the accuracy, sufficiency, or reliability or for any loss or injury resulting from the use of the information. Newly discovered hazards are frequent and this information may not be completely up to date.

Copyright ©
Health Canada, 2001

[Material Safety Data Sheets - Index]