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MATERIAL SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENTNAME: Diphtheroids SYNONYM OR CROSS REFERENCE: Any member of Corynebacterium other than C. diphtheriae; pseudodiphtheria; Proprionibacterium; C. bovis, C. xerosis, C. pyogenes, C. haemolyticum, C. pseudotuberculosis, C. ulcerans CHARACTERISTICS: Gram positive straight to slightly curved rods; nonsporulating; non-motile; irregularly stained, sometimes granular; may be arranged in angular and palisade groups SECTION II - HEALTH HAZARDPATHOGENICITY: Includes human and animal parasites and pathogens as well as nonpathogens; C. haemolyticum - associated with pharangitis and skin ulcers in man; C. pseudotuberculosis - usually disease of lower animals but can cause zoonotic disease in humans; C. pyogenes - toxicogenic in animals and isolated from human pharyngitis and skin lesions; C. ulcerans - toxigenic causing nasopharyngeal infections; C. xerosis - opportunistic species found in conjunctival sac and on skin and mucous membranes EPIDEMIOLOGY: Worldwide HOST RANGE: Humans, many domestic animals - cattle, sheep, goats, horses, pigs INFECTIOUS DOSE: Unknown MODE OF TRANSMISSION: Usually opportunistic pathogens; contact with infected animals or food INCUBATION PERIOD: Unknown COMMUNICABILITY: Low SECTION III - DISSEMINATIONRESERVOIR: Many domestic animals - cattle, sheep, goats, pigs, horses; deer; mice and rats ZOONOSIS: Yes, depending on species VECTORS: None SECTION IV - VIABILITYDRUG SUSCEPTIBILITY: Sensitive to penicillin, erythromycin and tetracyline SUSCEPTIBILITY TO DISINFECTANTS: Susceptible to many disinfectants - 1% sodium hypochlorite, 70% ethanol, glutaraldehyde, formaldehyde, iodines PHYSICAL INACTIVATION: Sensitive to moist heat (121·C for at least 15 min) and dry heat (160-170·C for at least 1 hour) SURVIVAL OUTSIDE HOST: Some species do not survive well outside of host SECTION V - MEDICALSURVEILLANCE: Monitor for symptoms; immunological techniques are not available FIRST AID/TREATMENT: Antibiotic therapy IMMUNIZATION: None PROPHYLAXIS: Antibiotic prophylaxis SECTION VI - LABORATORY HAZARDSLABORATORY-ACQUIRED INFECTIONS: 33 reported cases of C. diphtheria; no reported cases with other Corynebacterium spp. SOURCES/SPECIMENS: Exudates or secretions of the nose, throat, pharynx; wound exudates; blood; skin PRIMARY HAZARDS: Inhalation of infectious aerosols and droplets; accidental parenteral inoculation; ingestion SPECIAL HAZARDS: None SECTION VII - RECOMMENDED PRECAUTIONS CONTAINMENT REQUIREMENTS: Biosafety level 2 practices, containment equipment and facilities for all activities involving known or potentially infected clinical materials or cultures; animal-biosafety level 2 facilities for studies utilizing infected laboratory animals PROTECTIVE CLOTHING: Laboratory coat; gloves when direct contact with infectious materials is unavoidable OTHER PRECAUTIONS: None SECTION VIII - HANDLING INFORMATIONSPILLS: Allow aerosols to settle; wearing protective clothing, gently cover spill with absorbent paper towel and apply 1% sodium hypochlorite, starting at perimeter and working towards the centre; allow sufficient contact time (30 min) before clean up DISPOSAL: Decontaminate before disposal; steam sterilization, chemical disinfection, incineration STORAGE: In sealed containers that are appropriately labelled SECTION IX - MISCELLANEOUS INFORMATIONDate prepared: September 1996 Prepared by: Office of Biosafety LCDC Although the information, opinions and recommendations contained in this Material Safety Data Sheet are compiled from sources believed to be reliable, we accept no responsibility for the accuracy, sufficiency, or reliability or for any loss or injury resulting from the use of the information. Newly discovered hazards are frequent and this information may not be completely up to date.
[Material Safety Data Sheets - Index]
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Last Updated: 1997-10-11 | ![]() |