Chemical Substances in Future Batches of the Challenge
Help on accessing alternative formats, such as PDF, MP3 and WAV files, can be obtained in the alternate format help section.
In February, May and August of 2007, the Minister of the Environment and the Minister of Health released Notices in the Canada Gazette for the first three groups of substances identified under the Challenge. Industry and interested stakeholders have been invited to submit any information that may be used to inform risk assessment and to develop and benchmark best practices for risk management and product stewardship. Subsequent groups of substances are being released every three months.
Environment Canada and Health Canada have been developing a batch selection strategy for the remaining substances in the Challenge. The substances in batch 3 have now been launched, and the substances that the Minister of the Environment and the Minister of Health are proposing to assign to upcoming batches of the Challenge (batches 4 through 12) were identified in a Notice in the Canada Gazette entitled Notice of identification of the third batch and the next proposed batches of the remaining substances in the Challenge, published on May 12, 2007.
 Canada Gazette Vol. 141, No. 19 - May 12, 2007 (PDF)
Any person may, within 120 days of publication of this notice (ending September 10, 2007), file comments with respect to the proposed batches 5 to 12. The substances assigned to batch 4 have now been finalized, following a 60-day public comment period that ended on July 11, 2007.
Formal notice of identification of substances assigned to a batch will continue to be issued in the Canada Gazette, Part I, 3 months before a challenge is issued for that batch.
Confirmed Batch 4 Challenge Substances
A. Substances identified as persistent, bioaccumulative, and inherently toxic to non-human organisms and believed to be in commercial use in Canada
| CAS No. |
Substance Name |
| 115-39-9* |
Phenol, 4,4 -(3H-2,1-benzoxathiol-3-ylidene)bis[2,6-dibromo-, S,S-dioxide |
| 115-40-2* |
Phenol, 4,4 -(3H-2,1-benzoxathiol-3-ylidene)bis[2-bromo-6-methyl-, S,S-dioxide |
| 125-31-5* |
Phenol, 4,4 -(3H-2,1-benzoxathiol-3-ylidene)bis[2,5-dimethyl-, S,S-dioxide |
| 1154-59-2* |
Benzamide, 3,5-dichloro-N-(3,4-dichlorophenyl)-2-hydroxy- |
| 1176-74-5* |
Benzoic acid, 2-[(3,5-dibromo-4-hydroxyphenyl)(3,5-dibromo-4-oxo-2,5-cyclohexadien-1-ylidene)methyl]-, ethyl ester |
| 17321-77-6 |
5H-Dibenz[b,f]azepine-5-propanamine, 3-chloro-10,11-dihydro-N,N-dimethyl-, monohydrochloride |
| 62625-32-5 |
Phenol, 4,4 -(3H-1,2-benzoxathiol-3-ylidene)bis[2,6-dibromo-3-methyl-, S,S-dioxide, monosodium salt |
| 64325-78-6* |
Adenosine, N-benzoyl-5 -O-[bis(4-methoxyphenyl)phenylmethyl]-2 -deoxy- |
| 68308-48-5 |
Amines, tallow alkyl, ethoxylated, phosphates |
| 68443-10-7* |
Amines, C18-22-tert-alkyl, ethoxylated |
| 68921-45-9 |
Benzenamine, N-phenyl-, reaction products with styrene and 2,4,4-trimethylpentene |
| 70776-86-2* |
2-Butanone, 4-[[[1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenyl]methyl](3-oxo-3-phenylpropyl)amino]-, [1R-(1a,4aß,10aa)]- |
| 79357-73-6* |
Amines, C18-22-tert-alkyl, (chloromethyl)phosphonates (2:1) |
* Substances for which no response was received to the notice published in the Canada Gazette, Part I, Vol. 140, No. 9, under section 71 of the Canadian Environmental Protection Act, 1999, on March 4, 2006, but for which stakeholders submitted the Declaration of Non-Engagement form indicating their interest in the substances.
B. Substances identified as a high hazard to humans and presenting a high likelihood of exposure to individuals in Canada
| CAS No. |
Substance Name |
| 64-67-5 |
Sulfuric acid, diethyl ester |
| 75-28-5 |
Propane, 2-methyl- |
| 77-78-1 |
Sulfuric acid, dimethyl ester |
| 106-97-8 |
Butane |
| 110-54-3 |
Hexane |
Proposed Batch 5 Challenge Substances
A. Substances identified as persistent, bioaccumulative, and inherently toxic to non-human organisms and believed to be in commercial use in Canada
| CAS No. |
Substance Name |
| 5261-31-4 |
Propanenitrile, 3-[[2-(acetyloxy)ethyl][4-[(2,6-dichloro-4-nitrophenyl)azo]phenyl]amino]- |
| 6232-56-0* |
Ethanol, 2-[[4-[(2,6-dichloro-4-nitrophenyl)azo]phenyl]methylamino]- |
| 12239-34-8 |
Acetamide, N-[5-[bis[2-(acetyloxy)ethyl]amino]-2-[(2-bromo-4,6-dinitrophenyl)azo]-4-ethoxyphenyl]- |
| 16421-40-2* |
Acetamide, N-[5-[[2-(acetyloxy)ethyl](phenylmethyl)amino]-2-[(2-chloro-4,6-dinitrophenyl)azo]-4-methoxyphenyl]- |
| 16421-41-3* |
Acetamide, N-[5-[[2-(acetyloxy)ethyl](phenylmethyl)amino]-2-[(2,4-dinitrophenyl)azo]-4-methoxyphenyl]- |
| 17464-91-4* |
Ethanol, 2,2'-[[4-[(2-bromo-6-chloro-4-nitrophenyl)azo]-3-chlorophenyl]imino]bis- |
| 23355-64-8* |
Ethanol, 2,2'-[[3-chloro-4-[(2,6-dichloro-4-nitrophenyl)azo]phenyl]imino]bis- |
| 26850-12-4 |
Propanamide, N-[5-[bis[2-(acetyloxy)ethyl]amino]-2-[(2-chloro-4-nitrophenyl)azo]phenyl]- |
| 29765-00-2 |
Benzamide, N-[5-[bis[2-(acetyloxy)ethyl]amino]-2-[(4-nitrophenyl)azo]phenyl]- |
| 52697-38-8 |
Acetamide, N-[2-[(2-bromo-4,6-dinitrophenyl)azo]-5-(diethylamino)phenyl]- |
| 55281-26-0 |
Propanenitrile, 3-[[4-[(2,6-dibromo-4-nitrophenyl)azo]phenyl]ethylamino]- |
| 55619-18-6* |
Ethanol, 2,2'-[[4-[(2,6-dibromo-4-nitrophenyl)azo]phenyl]imino]bis-, diacetate (ester) |
| 72927-94-7* |
Benzenamine, 4-[(2,6-dichloro-4-nitrophenyl)azo]-N-(4-nitrophenyl)- |
* Substances for which no response was received to the notice published in the Canada Gazette, Part I, Vol. 140, No. 9, under section 71 of the Canadian Environmental Protection Act, 1999, on March 4, 2006, but for which stakeholders submitted the Declaration of Non-Engagement form indicating their interest in the substances.
B. Substances identified as a high hazard to humans and presenting a high likelihood of exposure to individuals in Canada
| CAS No. |
Substance Name |
| 75-12-7 |
Formamide |
| 79-06-1 |
2-Propenamide |
| 79-07-2 |
Acetamide, 2-chloro- |
| 115-96-8 |
Ethanol, 2-chloro-, phosphate (3:1) |
| 126-73-8 |
Phosphoric acid tributyl ester |
| 127-19-5 |
Acetamide, N,N-dimethyl- |
Proposed Batch 6 Challenge Substances
A. Substances identified as persistent, bioaccumulative, and inherently toxic to non-human organisms and believed to be in commercial use in Canada
| CAS No. |
Substance Name |
| 85-86-9 |
2-Naphthalenol, 1-[[4-(phenylazo)phenyl]azo]- |
| 1229-55-6* |
2-Naphthalenol, 1-[(2-methoxyphenyl)azo]- |
| 1937-37-7* |
2,7-Naphthalenedisulfonic acid, 4-amino-3-[[4'-[(2,4-diaminophenyl)azo][1,1'-biphenyl]-4-yl]azo]-5-hydroxy-6-(phenylazo)-, disodium salt |
| 3118-97-6* |
2-Naphthalenol, 1-[(2,4-dimethylphenyl)azo]- |
| 6250-23-3* |
Phenol, 4-[[4-(phenylazo)phenyl]azo]- |
| 6253-10-7* |
Phenol, 4-[[4-(phenylazo)-1-naphthalenyl]azo]- |
| 6300-37-4* |
Phenol, 2-methyl-4-[[4-(phenylazo)phenyl]azo]- |
| 6358-57-2 |
2,7-Naphthalenedisulfonic acid, 3-[[2,2'-dimethyl-4'-[[4-[[(4-methylphenyl)sulfonyl]oxy]phenyl]azo][1,1'-biphenyl]-4-yl]azo]-4-hydroxy-, disodium salt |
| 6535-42-8 |
1-Naphthalenol, 4-[(4-ethoxyphenyl)azo]- |
| 7147-42-4* |
Butanamide, 2,2'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2-methylphenyl)-3-oxo- |
| 19800-42-1 |
Phenol, 4-[[2-methoxy-4-[(4-nitrophenyl)azo]phenyl]azo]- |
| 21811-64-3* |
Phenol, 4,4'-[1,4-phenylenebis(azo)]bis- |
| 93805-00-6* |
Phenol, 4-[[2-methoxy-4-[(2-methoxyphenyl)azo]-5-methylphenyl]azo]- |
* Substances for which no response was received to the notice published in the Canada Gazette, Part I, Vol. 140, No. 9, under section 71 of the Canadian Environmental Protection Act, 1999, on March 4, 2006, but for which stakeholders submitted the Declaration of Non-Engagement form indicating their interest in the substances.
B. Substances identified as a high hazard to humans and presenting a high likelihood of exposure to individuals in Canada
| CAS No. |
Substance Name |
| 74-87-3 |
Methane, chloro- |
| 100-44-7 |
Benzene, (chloromethyl)- |
| 107-05-1 |
1-Propene, 3-chloro- |
| 117-82-8 |
1,2-Benzenedicarboxylic acid, bis(2-methoxyethyl) ester |
| 68515-42-4 |
1,2-Benzenedicarboxylic acid, di-C7-11-branched and linear alkyl esters |
Proposed Batch 7 Challenge Substances
A. Substances identified as persistent, bioaccumulative, and inherently toxic to non-human organisms and believed to be in commercial use in Canada
| CAS No. |
Substance Name |
| 1325-86-6* |
1-Naphthalenemethanol, α,α-bis[4-(diethylamino)phenyl]-4-(ethylamino)- |
| 6407-74-5* |
3H-Pyrazol-3-one, 4-[(2-chlorophenyl)azo]-2,4-dihydro-5-methyl-2-phenyl- |
| 6407-78-9* |
3H-Pyrazol-3-one, 4-[(2,4-dimethylphenyl)azo]-2,4-dihydro-5-methyl-2-phenyl- |
| 6786-83-0* |
1-Naphthalenemethanol, α,α-bis[4-(dimethylamino)phenyl]-4-(phenylamino)- |
| 16586-42-8 |
Propanenitrile, 3-[ethyl[3-methyl-4-[(6-nitro-2-benzothiazolyl)azo]phenyl]amino]- |
| 25176-89-0* |
Propanenitrile, 3-[[4-[(5,6-dichloro-2-benzothiazolyl)azo]phenyl]ethylamino]- |
| 29398-96-7* |
[1,1'-Biphenyl]-4,4'-diamine, N,N'-bis(2,4-dinitrophenyl)-3,3'-dimethoxy- |
| 72968-82-2 |
Methanesulfonamide, N-[2-[(2,6-dicyano-4-methylphenyl)azo]-5-(dipropylamino)phenyl]- |
| 106276-78-2* |
Benzoic acid, 2,3,4,5-tetrachloro-6-cyano-, methyl ester, reaction products with 4-[(4-aminophenyl)azo]-3-methylbenzenamine and sodium methoxide |
* Substances for which no response was received to the notice published in the Canada Gazette, Part I, Vol. 140, No. 9, under section 71 of the Canadian Environmental Protection Act, 1999, on March 4, 2006, but for which stakeholders submitted the Declaration of Non-Engagement form indicating their interest in the substances.
B. Substances identified as a high hazard to humans and presenting a high likelihood of exposure to individuals in Canada
| CAS No. |
Substance Name |
| 78-59-1 |
2-Cyclohexen-1-one, 3,5,5-trimethyl- |
| 90-94-8 |
Methanone, bis[4-(dimethylamino)phenyl]- |
| 96-29-7 |
2-Butanone, oxime |
| 123-91-1 |
1,4-Dioxane |
| 2426-08-6 |
Oxirane, (butoxymethyl)- |
Proposed Batch 8 Challenge Substances
A. Substances identified as persistent, bioaccumulative, and inherently toxic to non-human organisms and believed to be in commercial use in Canada
| CAS No. |
Substance Name |
| 626-39-1* |
Benzene, 1,3,5-tribromo- |
| 944-61-6 |
Benzene, 1,2,3,4-tetrachloro-5,6-dimethoxy- |
| 2215-35-2 |
Zinc, bis[O,O-bis(1,3-dimethylbutyl) phosphorodithioato-S,S']-, (T-4)- |
| 17540-75-9 |
Phenol, 2,6-bis(1,1-dimethylethyl)-4-(1-methylpropyl)- |
| 65140-91-2 |
Phosphonic acid, [[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]-, monoethyl ester, calcium salt (2:1) |
| 68551-44-0 |
Fatty acids, C6-19-branched, zinc salts |
| 70331-94-1* |
Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, (1,2-dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl) ester |
| 72102-55-7 |
Methylium, [4-(dimethylamino)phenyl]bis[4-(ethylamino)-3-methylphenyl]-, acetate |
| 75768-65-9 |
Phosphonium, triphenyl(phenylmethyl)-, salt with 4,4 -[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis[phenol] (1:1) |
* Substances for which no response was received to the notice published in the Canada Gazette, Part I, Vol. 140, No. 9, under section 71 of the Canadian Environmental Protection Act, 1999, on March 4, 2006, but for which stakeholders submitted the Declaration of Non-Engagement form indicating their interest in the substances.
B. Substances identified as a high hazard to humans and presenting a high likelihood of exposure to individuals in Canada
| CAS No. |
Substance Name |
| 139-13-9 |
Glycine, N,N-bis(carboxymethyl)- |
| 7440-48-4 |
Cobalt |
| 7646-79-9 |
Cobalt chloride |
| 10124-43-3 |
Sulfuric acid, cobalt(2+) salt (1:1) |
| 25013-16-5 |
Phenol, (1,1-dimethylethyl)-4-methoxy- |
Proposed Batch 9 Challenge Substances
A. Substances identified as persistent, bioaccumulative, and inherently toxic to non-human organisms and believed to be in commercial use in Canada
| CAS No. |
Substance Name |
| 475-71-8* |
Benzo[h]benz[5,6]acridino[2,1,9,8-klmna]acridine-8,16-dione |
| 509-34-2 |
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-bis(diethylamino)- |
| 1326-05-2 |
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-, lead salt |
| 2134-15-8* |
Benzoic acid, 2,3,4,5-tetrachloro-6-(2,4,5,7-tetrabromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)- |
| 2379-74-0 |
Benzo[b]thiophen-3(2H)-one, 6-chloro-2-(6-chloro-4-methyl-3-oxobenzo[b]thien-2(3H)-ylidene)-4-methyl- |
| 7328-97-4 |
Oxirane, 2,2' ,2'' ,2''' -[1,2-ethanediylidenetetrakis(4,1-phenyleneoxymethylene)]tetrakis- |
| 14295-43-3* |
Benzo[b]thiophen-3(2H)-one, 4,7-dichloro-2-(4,7-dichloro-3-oxobenzo[b]thien-2(3H)-ylidene)- |
| 38465-55-3* |
Nickel, bis[1-[4-(dimethylamino)phenyl]-2-phenyl-1,2-ethenedithiolato(2-)-S,S']- |
| 41556-26-7 |
Decanedioic acid, bis(1,2,2,6,6-pentamethyl-4-piperidinyl) ester |
| 58161-93-6* |
Benzoic acid, 4-[1-[[(2,4-dichlorophenyl)amino]carbonyl]-3,3-dimethyl-2-oxobutoxy]- |
| 64338-16-5 |
7-Oxa-3,20-diazadispiro[5.1.11.2]heneicosan-21-one, 2,2,4,4-tetramethyl- |
* Substances for which no response was received to the notice published in the Canada Gazette, Part I, Vol. 140, No. 9, under section 71 of the Canadian Environmental Protection Act, 1999, on March 4, 2006, but for which stakeholders submitted the Declaration of Non-Engagement form indicating their interest in the substances.
B. Substances identified as a high hazard to humans and presenting a high likelihood of exposure to individuals in Canada
| CAS No. |
Substance Name |
| 88-12-0 |
2-Pyrrolidinone, 1-ethenyl- |
| 93-15-2 |
Benzene, 1,2-dimethoxy-4-(2-propenyl)- |
| 1309-64-4 |
Antimony oxide (Sb2O3) |
| 1314-62-1 |
Vanadium oxide (V2O5) |
| 7758-01-2 |
Bromic acid, potassium salt |
Proposed Batch 10 Challenge Substances
A. Substances identified as persistent, bioaccumulative, and inherently toxic to non-human organisms and believed to be in commercial use in Canada
| CAS No. |
Substance Name |
| 42739-61-7 |
Nickel, bis[2,3-bis(hydroxyimino)-N-(2-methoxyphenyl)butanamidato]- |
| 64365-17-9 |
Resin acids and Rosin acids, hydrogenated, esters with pentaerythritol |
| 65997-06-0 |
Rosin, hydrogenated |
| 65997-13-9 |
Resin acids and Rosin acids, hydrogenated, esters with glycerol |
| 68648-53-3 |
Resin acids and Rosin acids, hydrogenated, esters with triethylene glycol |
| 85702-90-5 |
2,9,11,13-Tetraazanonadecanethioic acid, 19-isocyanato-11-(6-isocyanatohexyl)-10,12-dioxo-, S-[3-(trimethoxysilyl)propyl] ester |
| 124751-15-1* |
Resin acids and Rosin acids, fumarated, barium salts |
* Substances for which no response was received to the notice published in the Canada Gazette, Part I, Vol. 140, No. 9, under section 71 of the Canadian Environmental Protection Act, 1999, on March 4, 2006, but for which stakeholders submitted the Declaration of Non-Engagement form indicating their interest in the substances.
B. Substances identified as a high hazard to humans and presenting a high likelihood of exposure to individuals in Canada
| CAS No. |
Substance Name |
| 75-52-5 |
Methane, nitro- |
| 79-46-9 |
Propane, 2-nitro- |
| 88-72-2 |
Benzene, 1-methyl-2-nitro- |
| 302-01-2 |
Hydrazine |
| 330-54-1 |
Urea, N'-(3,4-dichlorophenyl)-N,N-dimethyl- |
Proposed Batch 11 Challenge Substances
A. Substances identified as persistent, bioaccumulative, and inherently toxic to non-human organisms and believed to be in commercial use in Canada
| CAS No. |
Substance Name |
| 603-33-8* |
Bismuthine, triphenyl- |
| 10448-09-6* |
Cyclotetrasiloxane, heptamethylphenyl- |
| 40615-36-9* |
Benzene, 1,1'-(chlorophenylmethylene)bis[4-methoxy- |
| 64111-81-5* |
Phenol, 2-phenoxy-, trichloro deriv. |
| 68412-48-6 |
2-Propanone, reaction products with diphenylamine |
| 68478-45-5 |
1,4-Benzenediamine, N,N'-mixed tolyl and xylyl derivs. |
| 68952-02-3 |
Siloxanes and Silicones, Me 3,3,3-trifluoropropyl, Me vinyl,hydroxy-terminated |
| 68953-84-4 |
1,4-Benzenediamine, N,N'-mixed Ph and tolyl derivs. |
| 69430-47-3 |
Siloxanes and Silicones, di-Me, reaction products with Me hydrogen siloxanes and 1,1,3,3-tetramethyldisiloxane |
| 70900-21-9 |
Siloxanes and Silicones, di-Me, hydrogen-terminated |
| 125328-28-1* |
Phenol, 4,4 -(1-methylethylidene)bis-, reaction products with hexakis(methoxymethyl)melamine |
* Substances for which no response was received to the notice published in the Canada Gazette, Part I, Vol. 140, No. 9, under section 71 of the Canadian Environmental Protection Act, 1999, on March 4, 2006, but for which stakeholders submitted the Declaration of Non-Engagement form indicating their interest in the substances.
B. Substances identified as a high hazard to humans and presenting a high likelihood of exposure to individuals in Canada
| CAS No. |
Substance Name |
| 98-01-1 |
2-Furancarboxaldehyde |
| 103-23-1 |
Hexanedioic acid, bis(2-ethylhexyl) ester |
| 107-22-2 |
Ethanedial |
| 140-88-5 |
2-Propenoic acid, ethyl ester |
| 149-57-5 |
Hexanoic acid, 2-ethyl- |
Proposed Batch 12 Challenge Substances
A. Substances identified as persistent, bioaccumulative, and inherently toxic to non-human organisms and believed to be in commercial use in Canada
| CAS No. |
Substance Name |
| 53-19-0 |
Benzene, 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]- |
| 56-95-1 |
2,4,11,13-Tetraazatetradecanediimidamide, N,N' -bis(4-chlorophenyl)-3,12-diimino-, diacetate |
| 107-51-7 |
Trisiloxane, octamethyl- |
| 116-66-5* |
1H-Indene, 2,3-dihydro-1,1,3,3,5-pentamethyl-4,6-dinitro- |
| 515-03-7* |
1- Naphthalenepropanol, α-ethenyldecahydro-2-hydroxy-α,2,5,5,8a-pentamethyl-, [1R-[1a(R*),2ß,4aß,8aα]]- |
| 3555-47-3 |
Trisiloxane, 1,1,1,5,5,5-hexamethyl-3,3-bis[(trimethylsilyl)oxy]- |
| 59709-38-5 |
ß-Alanine, N-[4-[(2-bromo-6-chloro-4-nitrophenyl)azo]phenyl]-N-(3-methoxy-3-oxopropyl)-, methyl ester |
| 68583-58-4 |
Ethanamine, N-ethyl-N-hydroxy-, reaction products with hexamethylcyclotrisiloxane, silica and 1,1,1-trimethyl-N-(trimethylsilyl)silanamine |
| 68937-51-9 |
Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, reaction products with ammonia, octamethylcyclotetrasiloxane and silica |
| 101200-53-7* |
Pyridine, 2-[3-(3-chlorophenyl)propyl]- |
* Substances for which no response was received to the notice published in the Canada Gazette, Part I, Vol. 140, No. 9, under section 71 of the Canadian Environmental Protection Act, 1999, on March 4, 2006, but for which stakeholders submitted the Declaration of Non-Engagement form indicating their interest in the substances.
B. Substances identified as a high hazard to humans and presenting a high likelihood of exposure to individuals in Canada
| CAS No. |
Substance Name |
| 102-06-7 |
Guanidine, N,N -diphenyl- |
| 1333-86-4 |
Carbon black |
| 14464-46-1 |
Cristobalite |
| 14808-60-7 |
Quartz |
| 68391-11-7 |
Pyridine, alkyl derivs. |
|
