Results of the Health-Related Components of
Categorization of the Domestic Substances List under CEPA 1999
Note on following
worksheets:
: Substances proposed as categorized "IN"
: Other High Health Priorities (Other priorities identified in
categorization but not meeting GPE, or P or B criteria)
P, B determinations provided by
Environment Canada on June 30th, 2006
GPE High Hazard (ID 1-36)
IPE High Hazard (ID 37-72)
FDA High Hazard (ID 73-93)
LPE High Hazard (ID 94-250)
High Hazard Petroleum Streams (ID 251-516)
GPE Moderate (ID 1-405)
IPE Moderate P and/or B (ID 406-490)
IPE Moderate requiring P and/or B decisions (ID 491-581)
Moderate Petroleum Streams (ID 582-631)
Moderate Petroleum Streams requiring P and/or B decisions (n = 10)
|
ComHaz
Low |
SimHaz
Low |
SimHaz
Criteria
Change |
PBiTeco
Change |
Previously
Assessed/
Risk Managed |
No Longer
on DSL |
TOTAL |
Low -
PrevAssess |
NA |
NA |
NA |
NA |
138 |
NA |
138 |
Low - LowHaz |
173 |
103 |
28 |
NA |
NA |
NA |
304 |
Deprioritized |
NA |
NA |
40 |
277 |
NA |
3 |
320 |
TOTAL |
173 |
103 |
68 |
277 |
138 |
3 |
762 |
Some additional substances were prioritized
for consideration on the basis of updates to weight of evidence hazard
determinations in the simple hazard tool or as a result of changes to
determinations of P and/or B. Next steps for these substances will be
considered post September, 2006.
Maximal List Subgroups (July 27, 2006):
Maximal
List Group |
Maximal List Subgroup |
Total |
High |
High - GPE |
36 |
High - IPE |
36 |
High - FDA |
21 |
High - LPE |
157 |
Petrol. - High - GPE |
65 |
Petrol. - High - IPE |
99 |
Petrol. - High - LPE |
102 |
Total: |
516 |
|
Moderate |
Mod - GPE |
405 |
Mod - IPE w/PB |
85 |
Mod - IPE wo/PB |
91 |
Petrol. - Mod - GPE |
25 |
Petrol. - Mod - IPE w/PB |
15 |
Petrol. - Mod - IPE wo/PB |
10 |
Total: |
631 |
|
Low |
Low - PrevAssess |
138 |
Low - LowHaz * |
304 |
Deprioritized |
320 |
Total: |
762 |
|
Post 2006 |
Total: |
36 |
* (Note: 30 of these
substances were also Deprioritized based on PBITeco changes)
NOTES:
1. Some substances are identified as a carcinogen or mutagen because the
substance may contain substances of concern, examples:
≥ 0.1 % w/w benzene;
≥ 0.1 % w/w 1,3
–butadiene;
≥
0.005 % w/w benzo[a]-pyrene;
≥
3.0 % dimethylsulfoxide extractable.
2. Carcinogenicity is determined by one or more of the following criteria:
European Community
- Category 1 (Known to be carcinogenic to humans)
- Category 2 (Regarded as if carcinogenic to humans)
- Category 3 (Causes concern for humans owing to
possible carcinogenic effects)
Health Canada (Guidelines for
Canadian Drinking Water Quality)
- Group I (Carcinogenic to humans)
- Group II (Probably carcinogenic to humans)
- Groups IIIA and IIIB (Possibly carcinogenic to
humans)
International Agency for Research
on Cancer
- Group 1 (Carcinogenic to humans)
- Group 2A (Probably carcinogenic to humans)
- Group 2B (Possibly carcinogenic to humans)
National Toxicology Program
- Known to be a human carcinogen
- Reasonably anticipated to be a human carcinogen
United States Environmental Protection Agency (US EPA) 1986 Carcinogenicity Guidelines
- Group A (Human carcinogen)
- Groups B1 and B2 (Probable human carcinogen)
- Group C (Possible human carcinogen)
US EPA 2003 Carcinogenicity Guidelines
- Carcinogenic to humans
- Likely to be carcinogenic to humans
- Suggestive evidence of carcinogenicity, but not sufficient to assess
- Human carcinogenic potential
3. Developmental Toxicity is determined by one of the following criteria:
European Community
- Category 1 (Known to cause developmental toxicity in humans)
- Category 2 (Regarded as if they cause developmental toxicity in humans)
- Category 3 (Causes concern for humans owing to possible developmental toxic effects)
4. Genotoxicity is determined by one of the following criteria:
European Community
- Category 1 (Known to be mutagenic to humans)
- Category 2 (Regarded as if mutagenic to humans)
- Category 3 (Causes concern for humans owing to
possible mutagenic effects)
5. Reproductive Toxicity is determined by one of the following criteria:
European Community
- Category 1 (Known to impair fertility in humans)
- Category 2 (Regarded as if they impair fertility in
humans)
- Category 3 (Causes concern for human fertility)
6. List of Acronyms and Abbreviations:
B - bioaccumulation/bioaccumulative
CAS RN - Chemical Abstracts Registry Number
ComHaz - Complex Hazard Tool
DSL - Domestic Substances List
FDA - Food and Drugs Act substances in commerce in 1984-1986 which were added to the DSL
GPE - Greatest Potential for Exposure
IPE - Intermediate Potential for Exposure
IThuman - inherently toxic to humans
LowHaz - Low Hazard
LPE - Lowest Potential for Exposure
P - persistence/persistent
PBITeco - persistent and/or bioaccumulative and inherently toxic to non-human organisms
PrevAssess - Previously Assessed or Risk Managed
SimHaz - Simple Hazard Tool
w - with
wo - without
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