Special Pathogens

Heinz Feldmann
Chief, Special Pathogens Program
Associate Professor, Department of Medical Microbiology, University of Manitoba

Degrees: M.D., University of Giessen, Germany; Ph.D., University of Marburg, Germany

Telephone: 204-789-6019   Lab: 204-789-5097  
Fax: 204-789-2140                                                 
Email:  Heinz_Feldmann@phac-aspc.gc.ca

Research Interests:

The group is interested in studying viral hemorrhagic fever pathogens in regards to molecular epidemiology, molecular biology, pathogenesis and immune response. To do this, there is a strong  utilization of reverse genetics systems (minigenome systems and infectious clone systems). In addition, the group is interested in developing rapid, sensitive and specific diagnostic test systems for viral hemorrhagic fever pathogens and other related biocontainment agents including those that can be applied in the field.
  

Recent Publications:

1. Kobinger GP, Feldmann H, Zhi Y, Schumer G, Gao G, Feldmann F; Jones S, Wilson JM (2005). Chimpanzee adenovirus vaccine protects against Zaire Ebola virus. Virology: n press.

2. Ebihara H, Groseth A, Neumann G, Kawaoka Y, Feldmann H (2005). The role of reverse genetics sytems in studying viral hemorrhagic fevers. Thromb. Haemost. 94: 240-253.

3. Feldmann H, Jones ST, Schnittler HJ, Geisbert T (2005). Therapy and prophylaxis of Ebola virus infections. Curr. Opin. Investig. Drugs. 6: 823-830.

4. Grolla A, Lucht A, Dick D, Strong J, Feldmann H (2005).Laboratory diagnosis of Ebola and Marburg hemorrhagic fever. Bull. Soc. Pathol. Exot, 98: 205-209.

5. Wahl-Jensen VM, Afanasieva TA, Seebach J, Stroeher U, Feldmann H, Schnittler, HJ (2005). Effects of Ebola virus glycoproteins on endothelail cell activation and barrier function. J. Virol. 79: 10442-10450.

6. Neumann G, Ebihara H, Takada A, Noda T, Kobasa D, Jasenosky LD, Watanabe S, Kim JH, Feldmann H, Kawaoka Y (2005). Ebola virus VP40 late domains are not essential for viral replication in cell culture. J. Virol. 79: 10300-10307.

7. Jones SM, Feldmann, H, Stroeher U, Geisbert JB, Fernando L, Grolla A, Klenk HD, Sullivan NJ, Volchkov VE, Daddario KM, Hensley LE, Jahrling PB, Geisbert TW (2005). Live attenuated recombinant vaccine protects nonhumanprimates against Ebola and Marburg viruses. Nat. Med. 11: 786-790.

8. Geisbert TW, Jones S, Fritz EA, Shurtleff AC, Geisbert JB, Liebscher R, Grolla A, Stroeher U, Fernando L, Daddario KM, Gutieri MC, Mothe BR, Larsen T, Hensley LE, Jahrling PB, Feldmann H (2005). Development of a new vaccine for the prevention of Lassa fever. Plos Med. 2: 537-545.

9. Vieth S, Drosten C, Charrel R, Feldmann H, Guenther S (2005). Establishemnt of conventional and fluorescence resonance energy trasfer-based real-time PCR assays for detection of pathogenic New World arenaviruses. J. Clin. Virol. 32: 229-235.

10. Wahl-Jensen V, Kurz SK, Hazelton PR, Schnittler HJ, Stroeher U, Burton DR, Feldmann H (2005). Role of Ewbola virus secreted glycoproteins and virus-like particles in activation of human macrophages. J. Virol. 79: 2413-2419.

11. Haferkamp S, Fernando L, Schwarz TF, Feldmann H, Flick R (2005). Intracellular localization of Crimean-Congo hemorrhagic fever (CCHF) virus glycoproteins. Virol. Journal 25: 42.

12. Groseth A, Feldmann H, Theriault S, Mehmetoglu G, Flick R (2005). RNA polymerase I-driven minigenome system for Ebola viruses. J. Virol. 79: 4425-4433.

13. Theriault S, Groseth A, Neumann G, Kawaoka Y, Feldmann H (2004). Rescue of Ebola virus from cDNA using heterologous support proteins. Virus Res. 106: 43-50.

14. Flick K, Katz A, Overby A, Feldmann H, Pettersson RF, Flick R (2004). Functional analysis of the noncoding regions of the Uukuniemi virus (Bunyaviridae) RNA segments. J. Virol. 78: 11726-11738.

15. Feldmann H, Wahl-Jensen V, Jones SM, Stroeher U (2004). Ebola virus ecology: a continuing mystery. Trends. Microbiol. 12: 433-437.

16. Holbrook MR, Aronson JF, Campbell GA, Jones S, Feldmann H, Barrett AD (2004). An animal model for the tick-borne flavivirus – Omsk hemorrhagic fever. J. Infect. Dis. 191: 100-108.

17. Kobasa D, Takada A, Shinya K, Hatta M, Halfmann P, Theriault S, Suzuki H, Nishimura H, Mitamura K, Sugaya N,Usui T, Murata T, Maeda Y, Watanabe S, Suresh M, Suzuki T, Suzuki Y,  Feldmann H, Kawaoka Y (2004). Enhanced pathogenicity of influenza A viruses possessing the haemagglutinin of the 1918 pandemic virus. Nature 431: 703-707.

18. Hogan RJ, Gao G, Rowe T, Bell P, Flieder D, Paragas J, Kobinger GP, Wivel NA, Crystal RG, Boyer J, Feldmann H, Voss TG, Wilson JM (2004). Resolution of primary severe acute respiratory syndrome-associated cornovirus infection requires Stat1. J. Virol. 78: 11416-11421.

19. Cornu TI, Feldmann H, de la Torre JC (2004). Cells expressing the RING finger Z  protein are resistant to arenavirus infection. J. Viorl. 78: 2079-2983.

20. Garbutt M, Liebscher R, Wahl-Jensen V, Jones S, Moeller P, Wagner R, Volchkov V, Klenk HD, Feldmann H, Stroeher U. (2004). Properties of replication-competent vesicular stomatitis virus vectors expressing glycoproteins of filoviruses and arenaviruses. J. Viro. 78: 5458-5465.

21. He R, Leeson A, Ballantine M, Andonov A, Baker L, Dobie F, Li Y, Bastien N, Feldmann H, Ströher U, Theriault S, Cutts T, Cao J, Booth TF, Plummer FA, Tyler S, Li X (2004). Characterization of protein-protein interaction between the nucleocapsid protein and membrane protein of the SARS coronavirus. Virus Res.  105: 121-125.

22. Takada A, Fujioka K, Tsuiji M, Morikawa A, Higashi N, Ebihara H, Kobassa D, Feldmann H, Irimura T, Kawaoka Y. (2004). Human macrophage C-type lectin specific for galactose and N-acetylgalactosamine promotes filovirus entry. J. Virol. 78: 2943-2947.

23. Kinsella E, Martin SG, Grolla A, Czub M, Feldmann H, Flick R (2004). Sequence determination of the Crimean-Congo hemorrhagic fever virus L segment. Virology 321: 23-28.

24. Stroeher U, DiCaro A, Li Y, Strong JE, Aoki F, Plummer F, Jones SM, Feldmann H (2004). Sever acute respiratory syndrome-related coronavirus is inhibited by interferon-alpha. J. Infect. Dis. 189: 1164-1167.

25. Watanabe S, Watanabe T, Noda T, Takada A, Feldmann H, Jasenosky LD, Kawaoka Y (2004). Production of novel Ebola virus-like particles from cDNAs: an alternative to Ebola virus generation by reverse genetics. J. Virol. 78: 999-1005.

Laboratory Members:

Daryl Dick
Technician
Daryl_Dick@phac-aspc.gc.ca

Allen Grolla
Biologist
Allen_Grolla@phac-aspc.gc.ca

Friederike Feldmann
Technician
Friederike_Feldmann@phac-aspc.gc.ca

Hideki Ebihara
Research Assistant
Hideki_Ebihara@phac-aspc.gc.ca

Allison Groseth
Graduate student
Allison_Lacquement@phac-aspc.gc.ca

Steven Theriault
Graduate student
Steven_Theriault@phac-aspc.gc.ca

Adrienne Meyers
Graduate student
Adrienne_Meyers@phac-aspc.gc.ca

Darryl Falzarano
Graduate student
Darryl_Falzarano@phac-aspc.gc.ca

Kyle Brown
Graduate student
Kyle_Brown@phac-aspc.gc.ca

Thomas Hoenen
Graduate student
Thomas_Hoenen@phac-aspc.gc.ca