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Volume 21-21
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Advisory Committee on Epidemiology GUIDELINES FOR CONTROL OF MEASLES OUTBREAKS IN CANADA (Revised 1995)The Advisory Committee on Epidemiology (ACE) issued Guidelines for Measles Control in Canada in February 1991 (1). These Guidelines reflected a concerted approach to the control of measles in Canada based on high levels of measles immunization in the community, national surveillance using standard case definitions, and a focused attack on measles outbreaks. Following a single case of measles, outbreak control measures were initiated. These included laboratory confirmation of the diagnosis, intensified surveillance, and a major effort to identify all susceptible contacts. Defined as susceptible were all those who did not have documented evidence of immunization since 1980, physician-documented measles, or laboratory evidence of immunity. The outbreak control guidelines required that all susceptible contacts be offered immunization and those who refused be excluded from school, day care or college until 2 weeks after the last case. This very aggressive approach to controlling measles outbreaks required significant resources. Outbreaks of measles have continued to occur in spite of these initiatives and the usefulness of this resource-consuming approach has been questioned. With many unanswered questions about measles control, ACE recommended that a consensus meeting be held to develop national goals and to attempt to resolve many of the issues. The Consensus Conference on Measles, with participants from all provinces and territories, the federal government, national advisory bodies and organizations, and experts in the field from outside Canada, was held in late 1992 and the proceedings were published in May 1993 (2). This document, therefore, presents the revised guidelines for control of measles outbreaks in Canada based on the recommendations developed at the consensus conference. Immunization Primary prevention is the most effective way to prevent and control outbreaks of measles. For successful measles control, immunization of all susceptible individuals is required. Vaccine records should be accessible and allow timely identification and follow-up on non-immune children. All children in day-care centres, nurseries and schools should have age-appropriate proof of immunization monitored annually. Public health departments should give high priority to the development of electronic records in order to achieve this goal. Provinces and territories should move toward a province/territory-wide individual client immunization record system that includes date of birth and age of recipient, lot number and date of administration of all vaccines and all antigen combinations. The long-term goal whereby immunization records are linked to a unique health-care card number should be adopted. This will allow the development of standardized timing and methods for assessment of vaccine coverage, and provide comparable national data for analysis. The goal for measles control in Canada identified at the national consensus conference was the elimination of indigenous measles in Canada by the year 2005. To address this goal, the National Advisory Committee on Immunization (NACI) recommends a two-dose schedule of routine immunization; vaccination coverage for two doses of over 95%; documented proof of immunity for the population at risk; intensive surveillance and rapid reporting of measles cases; and prompt outbreak control measures to prevent spread from index cases. The consensus document recognizes that the highest priority should be placed on achieving and maintaining the one-dose coverage. The age at first dose should remain as soon as possible after the first birthday. When a two-dose strategy is implemented by provinces, the second dose should be given before school entry, at least 3 months after the first. For the full NACI statement on measles vaccine, please refer to the Canadian Immunization Guide, 4th edition, 1993, pages 70 to 76. Surveillance A. National Surveillance For effective surveillance it is necessary that each suspect case of measles be thoroughly investigated to confirm the diagnosis. Clinicians should be asked to notify the medical officers of health of all suspect cases so that it may be determined if control measures are warranted. Efforts should be made to find additional cases and identify their contacts. B. Case Definition
1) Confirmed Case 2) Clinical Case 3) Suspect Case C. Laboratory Confirmation Confirmation is required for 1) all sporadic cases 2) the index case and enough cases to establish the existence of an outbreak Measles-specific IgM antibody is present in about 80% of cases at the time of rash onset and can still be detected up to 60 days later. Although its presence confirms measles, a negative result does not rule out the diagnosis. If measles is still suspected, IgM testing should be repeated. Optimally, blood for measles serology should be drawn 3 to 5 days after the first clinical signs. If results for measles (and rubella) IgM are negative in cases where blood was drawn within 3 days of onset of clinical signs, a further sample should be obtained for repeat testing. Occasionally false positives can occur and, as with any laboratory test, it is important to consider the epidemiologic and clinical information together with the laboratory report. Alternatively, measles infection can be confirmed serologically by demonstrating a significant rise in antibody titre, with the first (acute) serum sample taken within 7 days of rash onset and the second (convalescent) sample taken 10 days after the first. For ongoing laboratory surveillance for sporadic cases, consider including a "rash screen" (IgM serology for measles, rubella and parvovirus) when clinical history suggests measles-like illness during a non-epidemic period. D. History of Cases
1) Clinical and laboratory findings: 2) Vaccination history: 3) Epidemiologic data: Outbreaks The consensus conference noted that the 1991 measles control guidelines developed by ACE required selective revaccination program for outbreak control. These are not implemented in most jurisdictions and, in addition, selective revaccination of the pre-1980 group may not have had a significant impact on interrupting outbreaks. This outbreak control measure is aggressive and experience has shown that it may not be very effective. Although defined control measures in general have had some effect on reducing the size and duration of outbreaks, they are expensive and disruptive. The outbreak control guidelines have, therefore, been modified and reflect the recommendations made at the consensus conference. Outbreak control measures should be initiated with the identification of a single case clinically compatible with measles. In closed populations, such as schools, investigation and management of cases and contacts should be completed within 10 days of the onset of rash in the index case for at least 80% of cases. A. Confirm the Diagnosis B. Intensify Surveillance C. Identify Susceptible Contacts In an outbreak, consider as susceptible all persons over 6 months of age
born after 1956 who do not have the following: D. Immunize or Exclude Susceptibles Infants 6 to 11 months of age who are contacts or who are likely to be exposed to measles should receive measles vaccine, or IG. These children should be revaccinated with MMR at age 12 to 15 months. Infants < 6 months of age are likely to be protected by passively transferred maternal antibody. If there is reason to believe otherwise, they may be protected by IG in appropriate doses. Any individual receiving IG must wait at least 5 months before vaccination with live measles vaccine or MMR. Any susceptible contact of a case of measles who refuses vaccine or IG should be excluded from school, day care or college until protected or until 2 weeks have elapsed since the onset of the last case. This measure should be applied uniformly and should be implemented as soon as possible after measles has occurred in the school or day-care setting. E. Additional Measures F. Analyze the Outbreak A case in a Canadian resident who meets all the following criteria is considered
to be a preventable case: Risk factors that might explain vaccine failures may be identified by case-control analysis. In a community with 95% vaccine coverage and a vaccine efficacy of 90%, there will be more susceptibles among the vaccinated than the unvaccinated. The source of all cases, particularly the index case, should be identified whenever possible and common exposures should be documented. It is important to determine if the index case was imported. The effectiveness of control procedures should be reviewed. G. Recommend Control Strategy Changes H. Report When the analysis of the outbreak is completed, it should be provided to other jurisdictions and published in an appropriate publication such as the Canada Communicable Disease Report and Measles Update. Ongoing Education The importance of continual feedback of surveillance data to those in the
field will increase as measles control goals are reached. The consensus conference
recommended the following approaches to ongoing education:
1. Advisory Committee on Epidemiology. Guidelines for measles control in Canada. CDWR 1991;17:35-40. 2. LCDC. Consensus conference on measles. CCDR 1993;19:72-9.
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Last Updated: 1997-01-02 |