SARS PLpro Structure
NRC researchers have identified the complex physical structure of a protein used by the SARS virus to reproduce. The structure (shown here) was discovered using advanced computer prediction and modeling techniques. The model predicted that the protein would have a special activity, something later experimentally confirmed by the NRC team. This activity enables the virus to mimic and interfere with important cellular functions in the host, and might explain why the virus is so effective in avoiding cellular defences. The discovery could lead to new strategies for developing anti-viral drugs against SARS and related viruses. |
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