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Hong Kong's highest court overturned an American expatriate's murder conviction in a stunning reversal Thursday and ordered that she be retried for allegedly drugging her husband with a laced milkshake and bludgeoning him to death more than six years ago.

Hong Kong's Court of Final Appeal ruled that prosecutors improperly questioned Nancy Kissel at trial and that the judge wrongly allowed hearsay evidence. But the five-judge panel ordered that the 45-year-old mother of three to be kept in custody pending a bail application ahead of her second trial.

Ms. Kissel, who lost an earlier appeal of her conviction, smiled broadly when Chief Justice Andrew Li announced the ruling.

A friend of Ms. Kissel, Nancy Nassberg, told reporters that the defendant was “elated.” She said Ms. Kissel's parents were unable to travel from the U.S. for the hearing but had been notified of the result.

“I'm proud, very proud of Nancy. She was a good wife. She is a great mother, a great daughter, a great sister and a great friend,” Ms. Nassberg told reporters. “We think justice is served.”

Ms. Kissel has been serving a life sentence since she was convicted in September 2005.

The Kissel trial generated headlines with its graphic details about the breakdown of a wealthy expatriate couple's marriage. Robert Kissel was an investment banker at the Hong Kong offices of Goldman Sachs and Merrill Lynch, earning more than $5-million in the three years before his death, according to court documents. The couple lived in a luxury apartment complex nestled in the mountains of Hong Kong Island and hired two maids.

Prosecutors argued that Ms. Kissel planned her husband's murder on Nov. 2, 2003, first feeding him a milkshake laced with a cocktail of drugs, then bashing him on his head with a metal ornament when he was drowsy from the drink. She later asked workers to move her husband's body – wrapped in a sleeping bag and a carpet – to a storeroom in their apartment complex.

Ms. Kissel said her husband confronted her about a divorce, threatened to take away their children, attacked her with a baseball bat and tried to have anal sex with her. She said she killed him in self-defence.

The Court of Final Appeal sided with Ms. Kissel on two grounds – the manner in which prosecutors cross-examined her at trial and the relevance of testimony that her husband confided to others that he feared for his life.

Ms. Kissel's lawyers argued that prosecutors broke the law by asking her about material presented during her first bail hearing before trial. Ms. Kissel was granted bail on the argument that she was mentally fit to be released. But she then said during the trial she suffered from memory loss. Prosecutors tried to highlight the inconsistency.

“The persistent and vigorous cross-examination of the appellant was carried to such lengths as to generate a real risk of prejudicing unfairly the appellant in the eyes of the jury,” the judges said.

The justices also said the trial judge erred in allowing one of Mr. Kissel's friends and a private detective he hired to testify that he expressed worries that his wife may be plotting his murder. The “prejudicial” nature of that evidence outweighs its relevance in establishing Mr. Kissel's views on his marriage, they said.

“It is plainly in the interests of justice that there should be a retrial,” the judges said.

It wasn't immediately clear how soon a retrial would take place. Hong Kong's Department of Justice said it will issue a new murder indictment but didn't say when.

Even before the death, the Kissels' marriage was already in disrepair, trial testimony revealed. Ms. Kissel admitted that she had an affair with an electrician who worked at the couple's vacation home in the U.S. state of Vermont. Suspicious of his wife, Mr. Kissel installed spying software on his wife's computer and hired a private detective to monitor her in Vermont.

She accused him of alcohol and cocaine abuse and demands for anal and oral sex.

Mr. Kissel's brother, Andrew Kissel, was stabbed to death in 2006. The Connecticut developer was facing charges of real estate fraud and grand larceny at the time.

Andrew and his wife had looked after Robert's three children temporarily after their father's death, but custody was later transferred to the brothers' sister.

Although Hong Kong, a former British colony, is now ruled by China, it has kept a separate legal system and maintains its own courts.