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Treatment switch to dolutegravir with 2 nucleoside reverse transcriptase inhibitors (NRTI) in comparison to continuation with protease inhibitor/ritonavir among patient with HIV at risk for prior NRTI resistance: a cohort analysis of real-world data
Mohamed N’dongo Sangaré et al.
Abstract Background Switching antiretroviral regimens when HIV viremia is controlled for a new regimen is challenging when there is the potential for prior nucleoside reverse transcriptase inhibitor (NRTI) resistance. The objective was to study virologic outcomes after switching to dolutegravir compared to remaining on a ...
Short-term Adverse Events With BIC/FTC/TAF: Postmarketing Study
Edwin Hayes et al.
Abstract Bictegravir (BIC)/emtricitabine (FTC)/tenofovir alafenamide (TAF) was Food and Drug Administration approved in February 2018. The paucity of real-world data prompted this retrospective, observational evaluation of discontinuation rates, adverse effects, and virologic control. In a Southern US, predominantly ...
Association of early nasopharyngeal immune markers with COVID-19 clinical outcome: predictive value of CCL2/MCP-1
Beatriz Sierra et al.
Abstract Early recognition of severe forms of COVID-19 is essential for an opportune and effective intervention, reducing life risk complications. An altered inflammatory immune response seems to be associated to COVID-19´s pathogenesis and progression to severity. Here we demonstrated the utility of the early ...
Virological characterization of the first two COVID-19 patients diagnosed in Italy: phylogenetic analysis, virus shedding profile from different body sites and antibody response kinetics
Francesca Colavita et al.
Abstract Background The pathogenesis of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains unclear. We report the detection of viral RNA from different anatomical districts and the antibody profile in the first two COVID-19 cases diagnosed in Italy Methods We tested for SARS-CoV-2 RNA ...
A dynamic response to exposures of healthcare workers to newly diagnosed COVID-19 patients or hospital personnel, in order to minimize cross transmission and need for suspension from work during the outbreak
Carmela Schwartz, RN, MPH et al.
Abstract Background During the corona virus disease (COVID-19) epidemic, many healthcare workers (HCWs) were exposed to infected persons, leading to suspension from work. We describe a dynamic response to exposures of HCWs at the Hadassah Hospital, Jerusalem, to minimize the need for suspension from work. Methods We ...

Editor's Choice

Treatment switch to dolutegravir with 2 nucleoside reverse transcriptase inhibitors (NRTI) in comparison to continuation with protease inhibitor/ritonavir among patient with HIV at risk for prior NRTI resistance: a cohort analysis of real-world data
Mohamed N’dongo Sangaré et al.
Abstract Background Switching antiretroviral regimens when HIV viremia is controlled for a new regimen is challenging when there is the potential for prior nucleoside reverse transcriptase inhibitor (NRTI) resistance. The objective was to study virologic outcomes after switching to dolutegravir compared to remaining on a ...
Powassan virus neuropathology and genomic diversity in patients with fatal encephalitis
Erica Normandin et al.
Abstract Background Powassan virus (POWV) is an emerging cause of severe encephalitis; very little is known about human pathogenicity due to challenges in diagnosis and viral RNA recovery. We present three patients with fatal encephalitis due to POWV lineage II (deer tick virus). Methods We obtained 27 unique samples, ...
Percutaneous bone biopsy for diabetic foot osteomyelitis: a systematic review and meta-analysis
Marcos C Schechter et al.
Abstract Background Diabetes is the leading cause of lower extremity non-traumatic amputation globally, and diabetic foot osteomyelitis (DFO) is usually the terminal event prior to limb loss. Though guidelines recommend percutaneous bone biopsy (PBB) for microbiological diagnosis of DFO in several common scenarios, it is ...
HIV in the State of Texas of the United States: Past Reflections, Present Shortcomings and Future Needs of the Public Health Response
Ume L Abbas et al.
Abstract Ending the HIV Epidemic: A Plan for America aims to reduce HIV incidence in the United States by at least 90% by 2030, using diagnosis, treatment and prevention strategies. Texas is a Southern state, that has one of the highest numbers of new HIV diagnoses and people with HIV in the country, and where HIV ...

The Open Forum Infectious Diseases Podcast

Open Forum Infectious Diseases provides free podcast interviews with experts in the field, keeping you up to date with the latest research on your computer or on the go. Now available on Apple Podcasts or via your favorite podcast service.

Podcast 31: Debating the Top ID Internet Resources with Dr. Monica Mahoney

Monica Mahoney

In a pre-pandemic OFID podcast, OFID Editor in Chief Paul Sax, MD, takes on Monica Mahoney, PharmD, clinical pharmacy coordinator of infectious diseases at Beth Israel Deaconess Medical Center, in a podcast draft. This time, the pair debates their top ID internet resources (COVID-19 excluded).

Podcast 30: How to Conduct a Clinical Trial During a Pandemic—An Interview with Dr. David Boulware

David Boulware

In episode 30 of the OFID podcast, OFID Editor in Chief Paul Sax, MD, speaks with David Boulware, MD, MPH, about the large, double-blind, internet-based trial he and his team conducted finding hydroxychloroquine is no more effective at preventing COVID-19 infection than a placebo.

Podcast 29: COVID-19’s Siege on Elmhurst Hospital in New York City – An interview with Dr. Eric Bressman

Dr. Eric Bressman

In episode 29 of the OFID podcast, OFID Editor in Chief Paul Sax, MD, speaks candidly with Eric Bressman, MD, chief medical resident at Mt. Sinai Hospital, about confronting the onslaught of COVID-19 cases at Elmhurst Hospital, the disproportionate impact on the Queens community, and the toll on his colleagues and family.

Podcast 28: Tracking COVID-19 from a Journalist's Perspective with STAT's Helen Branswell

Helen Branswell

In episode 28 of the OFID podcast, OFID Editor in Chief Paul Sax, MD, speaks with Helen Branswell – a seasoned infectious diseases and global health reporter at STAT – a media company offering health, medicine, and scientific discovery reporting. She shares the turbulent pursuit of the Coronavirus Disease 2019 story.

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